Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

361 - 380 of 683 works

2008

Conference Publication

Investigation toward multi-epitope vaccine candidates using native chemical ligation

Fujita, Yoshio, Moyle, Peter M., Hieu, Suzanne, Simerska, Pavla and Toth, Istvan (2008). Investigation toward multi-epitope vaccine candidates using native chemical ligation. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21002

Investigation toward multi-epitope vaccine candidates using native chemical ligation

2008

Journal Article

The Fourth International Peptide Symposium: Discovery to drugs: The peptide pipeline

Benson, Heather and Toth, Istvan (2008). The Fourth International Peptide Symposium: Discovery to drugs: The peptide pipeline. Biopolymers, 90 (5), 588-588. doi: 10.1002/bip.21069

The Fourth International Peptide Symposium: Discovery to drugs: The peptide pipeline

2007

Journal Article

The synthesis and characterisation of a novel dendritic system for gene delivery

Coles, Daniel J., Yang, Shu, Esposito, Anna, Mitchell, Deanne, Minchin, Rodney F. and Toth, Istvan (2007). The synthesis and characterisation of a novel dendritic system for gene delivery. Tetrahedron, 63 (49), 12207-12214. doi: 10.1016/j.tet.2007.09.048

The synthesis and characterisation of a novel dendritic system for gene delivery

2007

Journal Article

Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System

Olive, C., Moyle, P. and Toth, I. (2007). Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System. Current Medicinal Chemistry, 14 (28), 2976-2988. doi: 10.2174/092986707782794069

Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System

2007

Journal Article

Enhancement of oral drug absorption - Effect of lipid conjugation on the enzymatic stability and intestinal permeability of L-GlU-L-Trp-NH2

Bergeon, JA and Toth, I (2007). Enhancement of oral drug absorption - Effect of lipid conjugation on the enzymatic stability and intestinal permeability of L-GlU-L-Trp-NH2. Bioorganic & Medicinal Chemistry, 15 (22), 7048-7057. doi: 10.1016/j.bmc.2007.07.040

Enhancement of oral drug absorption - Effect of lipid conjugation on the enzymatic stability and intestinal permeability of L-GlU-L-Trp-NH2

2007

Journal Article

Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery

Falconer, RA and Toth, I (2007). Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery. Bioorganic & Medicinal Chemistry, 15 (22), 7012-7020. doi: 10.1016/j.bmc.2007.07.048

Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery

2007

Journal Article

Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue

Blanchfield, J., Gallagher, O., Cros, C., Lewis, R., Alewood, P. and Toth, I. (2007). Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communication, 361 (1), 97-102. doi: 10.1016/j.bbrc.2007.06.138

Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue

2007

Journal Article

A technique for the synthesis of highly-pure, mono-epitopic, multi-valent lipid core peptide vaccines

Moyle, PM, Hari, Y, Huang, N, Olive, C, Good, MF and Toth, I (2007). A technique for the synthesis of highly-pure, mono-epitopic, multi-valent lipid core peptide vaccines. Tetrahedron Letters, 48 (29), 4965-4967. doi: 10.1016/j.tetlet.2007.05.129

A technique for the synthesis of highly-pure, mono-epitopic, multi-valent lipid core peptide vaccines

2007

Journal Article

Caco-2 cell permeability and stability of two D-glucopyranuronamide conjugates of thyrotropin-releasing hormone

Wessling, Susanne T., Ross, Benjamin P., Koda, Yasuko, Blanchfield, Joanne T. and Toth, Istvan (2007). Caco-2 cell permeability and stability of two D-glucopyranuronamide conjugates of thyrotropin-releasing hormone. Bioorganic & Medicinal Chemistry, 15 (14), 4946-4950. doi: 10.1016/j.bmc.2007.04.042

Caco-2 cell permeability and stability of two D-glucopyranuronamide conjugates of thyrotropin-releasing hormone

2007

Journal Article

Evaluation of Cell Tolerability of a Series of Lipoamino Acids Using Biological Membranes and a Biomembrane Model.

Pignatello, R., Noce, C., Campisi, A., Acquaviva, R., Bucolo, C., Puglisi, G. and Toth, I. (2007). Evaluation of Cell Tolerability of a Series of Lipoamino Acids Using Biological Membranes and a Biomembrane Model.. Current Drug Delivery, 4 (2), 109-121. doi: 10.2174/156720107780362348

Evaluation of Cell Tolerability of a Series of Lipoamino Acids Using Biological Membranes and a Biomembrane Model.

2007

Journal Article

Novel cationic lipophilic peptides for oligodeoxynucleotide delivery

Chan, E, Amon, M, Marano, R. J., Wimmer, N, Kearns, P. S., Manolios, N, Rakoczy, P. E. and Toth, I (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic & Medicinal Chemistry, 15 (12), 4091-4097. doi: 10.1016/j.bmc.2007.03.078

Novel cationic lipophilic peptides for oligodeoxynucleotide delivery

2007

Journal Article

Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines

Moyle, Peter M., Olive, Colleen, Ho, Mei-Fong, Pandey, Manisha, Dyer, Joanne, Suhrbier, Andreas, Fujita, Yoshio and Toth, Istvan (2007). Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines. Journal of Medicinal Chemistry, 50 (19), 4721-4727. doi: 10.1021/jm070287b

Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines

2007

Journal Article

The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test

Bulmer, A., Ried, K., Coombes, J., Blanchfield, J., Toth, I. and Wagner, K. (2007). The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 629 (2), 122-132. doi: 10.1016/j.mrgentox.2007.01.008

The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test

2007

Journal Article

Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide

Koda, Y., Shiotani, K., Toth, I., Tsuda, Y., Okada, Y. and Blanchfield, J. (2007). Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide. Bioorganic & Medicinal Chemistry Letters, 17 (7), 2043-2046. doi: 10.1016/j.bmcl.2007.01.051

Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide

2007

Journal Article

Permeability studies of Kavalactones using a Caco-2 cell monolayer model

Matthias, A., Blanchfield, J., Penman, K., Bone, K., Toth, I. and Lehmann, R. (2007). Permeability studies of Kavalactones using a Caco-2 cell monolayer model. Journal of Clinical Pharmacy and Therapeutics, 32 (3), 233-239. doi: 10.1111/j.1365-2710.2007.00810.x

Permeability studies of Kavalactones using a Caco-2 cell monolayer model

2007

Conference Publication

Enhancement of Oral Drug Absorption - Effect of Lipid and Glycoside Conjugation on the Enzymatic Stability and Intestinal Permeability of IM862

Bergeon, J., Chan, Y. and Toth, I. (2007). Enhancement of Oral Drug Absorption - Effect of Lipid and Glycoside Conjugation on the Enzymatic Stability and Intestinal Permeability of IM862. 4th International Peptide Symposium, Cairns QLD Australia, 21-25 October 2007. Australia: Australian Peptide Association.

Enhancement of Oral Drug Absorption - Effect of Lipid and Glycoside Conjugation on the Enzymatic Stability and Intestinal Permeability of IM862

2007

Conference Publication

Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.

Simerska, P., Abdel-Aal, A. B., McGeary, R., Moyle, P.M., Fujita, Y., Good, M.F. and Toth, I. (2007). Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.. 13th International Congress of Immunology, Rio de Janeiro, Brazil, August 21-25.

Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.

2007

Journal Article

Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

Khoshnejad, M., Young, P. R., Toth, I. and Minchin, R. F. (2007). Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery. Current Medicinal Chemistry, 14 (29), 3152-3156. doi: 10.2174/092986707782793989

Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

2007

Journal Article

Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation

Olive, C., Schulze, K., Sun, H. K., Ebensen, T., Horváth, A., Toth, I. and Guzman, C. A. (2007). Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation. Vaccine, 25 (10), 1789-1797. doi: 10.1016/j.vaccine.2006.11.031

Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation

2007

Conference Publication

Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine

Fujita, Y., Moyle, P., Abdel-Aal, A., Batzloff, M., Good, M. and Toth, I. (2007). Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.

Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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