Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

381 - 400 of 683 works

2007

Journal Article

Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

Khoshnejad, M., Young, P. R., Toth, I. and Minchin, R. F. (2007). Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery. Current Medicinal Chemistry, 14 (29), 3152-3156. doi: 10.2174/092986707782793989

Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

2007

Journal Article

Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation

Olive, C., Schulze, K., Sun, H. K., Ebensen, T., Horváth, A., Toth, I. and Guzman, C. A. (2007). Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation. Vaccine, 25 (10), 1789-1797. doi: 10.1016/j.vaccine.2006.11.031

Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation

2007

Conference Publication

Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine

Fujita, Y., Moyle, P., Abdel-Aal, A., Batzloff, M., Good, M. and Toth, I. (2007). Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.

Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine

2007

Conference Publication

Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate

Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. 20th American Peptide Symposium, Montréal, Quebec, Canada, 26-30 June 2007. HOBOKEN: Wiley Periodicals. doi: 10.1002/bip.20783

Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate

2007

Journal Article

A védőoltások gyógyszerkémiájának egyik legújabb fejezete. Zsír-aminosav komplexen alapuló vakcinák (Recent developments in prophylactic drug chemistry. Vaccines based on fatty-amino acid complexes)

Toth, I. (2007). A védőoltások gyógyszerkémiájának egyik legújabb fejezete. Zsír-aminosav komplexen alapuló vakcinák (Recent developments in prophylactic drug chemistry. Vaccines based on fatty-amino acid complexes). Magyar kémikusok lapja, 62, 274-276.

A védőoltások gyógyszerkémiájának egyik legújabb fejezete. Zsír-aminosav komplexen alapuló vakcinák (Recent developments in prophylactic drug chemistry. Vaccines based on fatty-amino acid complexes)

2007

Conference Publication

The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine

Abdel-Aal, A. M., Batzloff, M. R., Faria, A., Fujita, Y., Good, M. F., Phillipps, K. S. M., Simerska, P., Toth, I. and Zaman, M. (2007). The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine. 4th international Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007, Cairns, Queensland, Australia, 21 - 25 October 2007. Australian Peptide Association.

The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine

2007

Conference Publication

The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry

Coles, D., Yang, S., Esposito, A., Mitchell, D., Minchin, R. and Toth, I. (2007). The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.

The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry

2007

Conference Publication

Novel lipoamino acid based vaccine adjuvant carrier system

Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Novel lipoamino acid based vaccine adjuvant carrier system. International Congress of Immunology, Rio de Janeiro, Brazil, 21-25 August 2007. Toronto, Canada: Hogrefe & Huber.

Novel lipoamino acid based vaccine adjuvant carrier system

2006

Conference Publication

Epidermal penetration of a therapeutic peptide by lipid conjugation; stereo-selective peptide availability of a topical diastereomeric lipopeptide

Caccetta, Rima, Blanchfield, Joanne T., Harrison, Jessica, Toth, Istvan and Benson, Heather A. E. (2006). Epidermal penetration of a therapeutic peptide by lipid conjugation; stereo-selective peptide availability of a topical diastereomeric lipopeptide. doi: 10.1007/s10989-006-9024-5

Epidermal penetration of a therapeutic peptide by lipid conjugation; stereo-selective peptide availability of a topical diastereomeric lipopeptide

2006

Journal Article

Method for the Synthesis of Multi-Epitopic Streptococcus pyogenes Lipopeptide Vaccines Using Native Chemical Ligation

Moyle, P. M., Olive, C., Ho, M. F., Burgess, M., Karpati, L., Good, M. F. and Toth, I. (2006). Method for the Synthesis of Multi-Epitopic Streptococcus pyogenes Lipopeptide Vaccines Using Native Chemical Ligation. Journal of Organic Chemistry, 71 (18), 6846-6850. doi: 10.1021/jo060960p

Method for the Synthesis of Multi-Epitopic Streptococcus pyogenes Lipopeptide Vaccines Using Native Chemical Ligation

2006

Journal Article

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein

Olive, Colleen, Sun, Hsien Kuo, Ho, Mei‐Fong, Dyer, Joanne, Horvath, Aniko, Toth, Istvan and Good, Michael F. (2006). Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. Journal of Infectious Diseases, 194 (3), 316-324. doi: 10.1086/505580

Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein

2006

Journal Article

Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hvdrophobic peptide dramatically enhances in vitro and in vivo function

Amon, Michael A., Ali, Marina, Bender, Vera, Chan, Yiu-Ngok, Toth, Istvan and Manolios, Nicholas (2006). Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hvdrophobic peptide dramatically enhances in vitro and in vivo function. Biochimica Et Biophysica Acta-molecular Cell Research, 1763 (8), 879-888. doi: 10.1016/j.bbamcr.2006.04.013

Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hvdrophobic peptide dramatically enhances in vitro and in vivo function

2006

Journal Article

Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus

Olive, Colleen, Ho, Mei‐Fong, Dyer, Joanne, Lincoln, Douglas, Barozzi, Nadia, Toth, Istvan and Good, Michael F. (2006). Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus. Journal of Infectious Diseases, 193 (12), 1666-1676. doi: 10.1086/504266

Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus

2006

Journal Article

The lipid core peptide system in vaccine delivery

Toth, Istvan, Moyle, Peter, Karpati, Levente, Horvath, Aniko, Olive, Colleen and Good, Michael (2006). The lipid core peptide system in vaccine delivery. International Congress Series, 1289, 307-310. doi: 10.1016/j.ics.2005.11.057

The lipid core peptide system in vaccine delivery

2006

Conference Publication

Drug development of endomorphin-1

Del Borgo, M, Koda, Y., Blanchfield, J T, Toth, I and Okada, Y. (2006). Drug development of endomorphin-1. 29th European Peptide Symposium, Gdansk, 3-8 Sept, 2006. CHICHESTER: JOHN WILEY & SONS LTD.

Drug development of endomorphin-1

2006

Conference Publication

Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation

Moyle, P. M., Olive, C., Ho, M.-F., Good, M F and Toth, I (2006). Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 Nov 2006.

Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation

2006

Conference Publication

Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation

Moyle, P. M., Olive, C., Ho, M.-F. and Toth, I (2006). Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation. GPEN 2006, Lawrence, USA, 25 - 27 Oct, 2006.

Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation

2006

Journal Article

Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A Streptococcal vaccine, and subsequent immunological evaluation

Moyle, P. M., Olive, C., Ho, M. F., Good, M. F. and Toth, I. (2006). Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A Streptococcal vaccine, and subsequent immunological evaluation. Journal of Medicinal Chemistry, 49 (21), 6364-6370. doi: 10.1021/jm060475m

Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A Streptococcal vaccine, and subsequent immunological evaluation

2006

Conference Publication

The chemo-enzymatic synthesis of oligosaccharide-linked peptides aimed at improved drug delivery

Johnstone, Ken D., Dieckelmann, Manuela, Jennings, Michael P., Blanchfield, Joanne T. and Toth, Istvan (2006). The chemo-enzymatic synthesis of oligosaccharide-linked peptides aimed at improved drug delivery. 19th American Peptide Symposium, San Diego, CA, United States, 18-23 June 2005. New York, NY, United States: Springer. doi: 10.1007/978-0-387-26575-9_221

The chemo-enzymatic synthesis of oligosaccharide-linked peptides aimed at improved drug delivery

2006

Conference Publication

Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus

Abdel-Aal, A. M., Fujita, Y., Faria, A., Simerska, P., Batzloff, M. R., Good, M. F. and Toth, I. (2006). Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, Australia, 3-5 December 2006. Malvern, VIC: Australasian Pharmaceutical Science Association.

Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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