Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

321 - 340 of 683 works

2010

Journal Article

Thymine, adenine and lipoamino acid based gene delivery systems

Skwarczynski, Mariusz, Ziora, Zyta M., Coles, Daniel J., Lin, I-Chun and Toth, Istvan (2010). Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications, 46 (18), 3140-3142. doi: 10.1039/b924371b

Thymine, adenine and lipoamino acid based gene delivery systems

2009

Journal Article

Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates

Zhong, Wei, Skwarczynski, Mariusz and Toth, Istvan (2009). Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates. Current Drug Delivery, 6 (5), 520-527. doi: 10.2174/156720109789941650

Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates

2009

Journal Article

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

Abdelrahim, Adel. S., Ziora, Zyta M., Bergeon, Julie A., Moss, Anne R. and Toth, Istvan (2009). Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery. Tetrahedron, 65 (45), 9436-9442. doi: 10.1016/j.tet.2009.08.072

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

2009

Journal Article

A novel synthetic adjuvant enhances dendritic cell function

Phillipps, Karen S. M., Wykes, Michelle N., Liu, Xue Q., Brown, Melissa, Blanchfield, Joanne T. and Toth, Istvan (2009). A novel synthetic adjuvant enhances dendritic cell function. Immunology, 128 (1), e582-e588. doi: 10.1111/j.1365-2567.2008.03038.x

A novel synthetic adjuvant enhances dendritic cell function

2009

Journal Article

Dendritic peptide-based carriers for gene delivery

Coles, Daniel J. and Toth, Istvan (2009). Dendritic peptide-based carriers for gene delivery. Current Drug Delivery, 6 (4), 338-342. doi: 10.2174/156720109789000465

Dendritic peptide-based carriers for gene delivery

2009

Journal Article

2nd Annual Meeting of the Australian Chapter of the Controlled Release Society, Canberra 2009

Toth, Istvan (2009). 2nd Annual Meeting of the Australian Chapter of the Controlled Release Society, Canberra 2009. Current Drug Delivery, 6 (4), 321-321. doi: 10.2174/156720109789000528

2nd Annual Meeting of the Australian Chapter of the Controlled Release Society, Canberra 2009

2009

Journal Article

Oral vaccine delivery - New strategies and technologies

Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Oral vaccine delivery - New strategies and technologies. Current Drug Delivery, 6 (4), 347-358. doi: 10.2174/156720109789000537

Oral vaccine delivery - New strategies and technologies

2009

Journal Article

Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines

Zhong, Wei, Skwarczynski, Mariusz, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009). Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines. Tetrahedron, 65 (17), 3459-3464. doi: 10.1016/j.tet.2009.02.060

Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines

2009

Journal Article

Expression of maturation markers on murine dendritic cells in response to group A streptococcal lipopeptide vaccines

Yong, Michelle, Mitchell, Daniel, Caudron, Audrey, Toth, Istvan and Olive, Colleen (2009). Expression of maturation markers on murine dendritic cells in response to group A streptococcal lipopeptide vaccines. Vaccine, 27 (25-26), 3313-3318. doi: 10.1016/j.vaccine.2009.01.087

Expression of maturation markers on murine dendritic cells in response to group A streptococcal lipopeptide vaccines

2009

Journal Article

Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

Simerska, Pavla, Lu, Hao and Toth, Istvan (2009). Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope. Bioorganic & Medicinal Chemistry Letters, 19 (3), 821-824. doi: 10.1016/j.bmcl.2008.12.013

Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

2009

Journal Article

Design and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligation

Zhong, Wei, Skwarczynski, Mariusz, Fujita, Yoshio, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009). Design and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligation. Australian Journal of Chemistry, 62 (9), 993-999. doi: 10.1071/CH09065

Design and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligation

2009

Conference Publication

Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate

Toth, Istvan, Moyle, Peter M., Simerska, Pavla, Fujita, Yoshio, Olive, Colleen and Good, Michael F. (2009). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. 20th American Peptide Symposium, Montréal, Quebec, Canada, 26-30 June 2007. New York: Springer. doi: 10.1007/978-0-387-73657-0_154

Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate

2009

Book Chapter

Strategies in oral immunization

Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. (pp. 195-222) edited by Bernkop-Schnurch, Andreas. New York, United States: Springer. doi: 10.1007/978-1-4419-0200-9_11

Strategies in oral immunization

2009

Conference Publication

Vaccine delivery utilizing liposaccharides

Simerska, Pavla, McGeary, Ross P., Abdel-Aal, Abu-Baker M., Moyle, Peter M., Olive, Colleen, Good, Michael F. and Toth, Istvan (2009). Vaccine delivery utilizing liposaccharides. The 20th American Peptide Symposium, Montreal, Canada, 26-30 June, 2007. United States: Springer. doi: 10.1007/978-0-387-73657-0_153

Vaccine delivery utilizing liposaccharides

2009

Journal Article

Lipid core peptide system for gene, drug, and vaccine delivery

Zhong, Wei, Skwarczynski, Mariusz and Toth, Istvan (2009). Lipid core peptide system for gene, drug, and vaccine delivery. Australian Journal of Chemistry, 62 (9), 956-967. doi: 10.1071/CH09149

Lipid core peptide system for gene, drug, and vaccine delivery

2009

Journal Article

Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine

Yang, Shu, Coles, David J., Esposito, Anna, Mitchell, Deanne J., Toth, Istvan and Minchin, Rodney F. (2009). Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine. Journal of controlled release, 135 (2), 159-165. doi: 10.1016/j.jconrel.2008.12.015

Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine

2008

Conference Publication

Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation

Bergeon, Julie A., Chan, Yiu-Ngok, Charles, Bruce G. and Toth, Istvan (2008). Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation. doi: 10.1002/bip.21003

Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation

2008

Conference Publication

Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines

Toth, Istvan, Simerska, Pavla and Fujita, Yoshio (2008). Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines. doi: 10.1007/s10989-008-9147-y

Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines

2008

Journal Article

Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines

Toth, I., Simerska, P. and Fujita, Y. (2008). Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines. International Journal of Peptide Research and Therapeutics, 14 (4), 333-340. doi: 10.1007/s10989-008-9147-y

Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines

2008

Journal Article

Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates

Fujita, Yoshio, Abdel-Aal, Abu-Baker M., Wimmer, Norbert, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2008). Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates. Bioorganic & Medicinal Chemistry, 16 (19), 8907-8913. doi: 10.1016/j.bmc.2008.08.064

Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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