Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

Email: 

Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

682 works between 1972 and 2025
All (682) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (5) Edited Outputs (1)

261 - 280 of 682 works

2013

Journal Article

Use of mixed micelles for presentation of building blocks in a new combinatorial discovery methodology: proof-of-concept studies

New, Roger, Bansal, Gurpal S., Bogus, Michael, Zajkowska, Kasia, Rickelt, Steffen and Toth, Istvan (2013). Use of mixed micelles for presentation of building blocks in a new combinatorial discovery methodology: proof-of-concept studies. Molecules, 18 (3), 3427-3441. doi: 10.3390/molecules18033427

Use of mixed micelles for presentation of building blocks in a new combinatorial discovery methodology: proof-of-concept studies

2013

Journal Article

Synthesis and characterization of luteinizing hormone-releasing hormone (LHRH)-functionalized mini-dendrimers

Rafiee, Amirreza, Mansfeld, Friederike M., Moyle, Peter M. and Toth, Istvan (2013). Synthesis and characterization of luteinizing hormone-releasing hormone (LHRH)-functionalized mini-dendrimers. International Journal of Chemistry, 3 (1), 51-57. doi: 10.4236/ijoc.2013.31006

Synthesis and characterization of luteinizing hormone-releasing hormone (LHRH)-functionalized mini-dendrimers

2013

Journal Article

Strategies for intranasal delivery of vaccines

Zaman, Mehfuz, Chandrudu, Saranya and Toth, Istvan (2013). Strategies for intranasal delivery of vaccines. Drug Delivery and Translational Research, 39 (1), 100-109. doi: 10.1007/s13346-012-0085-z

Strategies for intranasal delivery of vaccines

2013

Journal Article

Liposome-based delivery system for vaccine candidates: constructing an effective formulation (vol 7, pg 1877, 2012)

Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2013). Liposome-based delivery system for vaccine candidates: constructing an effective formulation (vol 7, pg 1877, 2012). Nanomedicine, 8 (2), 312-312. doi: 10.2217/nnm.13.0

Liposome-based delivery system for vaccine candidates: constructing an effective formulation (vol 7, pg 1877, 2012)

2013

Journal Article

M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus

Skwarczynski, Mariusz, Kamaruzaman, Khairul A., Srinivasan, Saranya, Zaman, Mehfuz, Lin, I-Chun, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013). M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus. Current Drug Delivery, 10 (1), 39-45. doi: 10.2174/1567201811310010007

M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus

2013

Journal Article

Preface

Toth, Istvan (2013). Preface. Current Drug Delivery, 10 (1), 1-1. doi: 10.2174/1567201811310010001

Preface

2013

Journal Article

Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method

Hussein, Waleed M., Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2013). Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Organic and Biomolecular Chemistry, 11 (14), 2370-2376. doi: 10.1039/c3ob00030c

Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method

2013

Book Chapter

Lipo-peptides/saccharides in peptide vaccine delivery

Skwarczynskim, Mariusz, Zaman, Mehfuz and Toth, Istvan (2013). Lipo-peptides/saccharides in peptide vaccine delivery. Handbook of biologically active peptides. (pp. 571-579) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00078-6

Lipo-peptides/saccharides in peptide vaccine delivery

2013

Conference Publication

Modified connexin43 mimetic peptide shows higher efficacy in reducing retinal ganglion cell loss and vessel leak after retinal ischemia

Rupenthal, I., Chen, Y. S., Teague, R., Perrett, J., Danesh-Meyer, H., Toth, I. and Green, C. (2013). Modified connexin43 mimetic peptide shows higher efficacy in reducing retinal ganglion cell loss and vessel leak after retinal ischemia. European Association for Vision and Eye Research Annual Meeting 2013, Nice, France, 18-21 September 2013. Malden, MA, United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2013.1744.x

Modified connexin43 mimetic peptide shows higher efficacy in reducing retinal ganglion cell loss and vessel leak after retinal ischemia

2013

Journal Article

Peptide conjugation via CuAAC 'click' chemistry

Ahmad Fuaad, Abdullah A. H., Azmi, Fazren, Skwarczynski, Mariusz and Toth, Istvan (2013). Peptide conjugation via CuAAC 'click' chemistry. Molecules, 18 (11), 13148-13174. doi: 10.3390/molecules181113148

Peptide conjugation via CuAAC 'click' chemistry

2012

Journal Article

Liposome-based delivery system for vaccine candidates: constructing an effective formulation

Giddam, Ashwin Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2012). Liposome-based delivery system for vaccine candidates: constructing an effective formulation. Nanomedicine, 7 (12), 1877-1893. doi: 10.2217/nnm.12.157

Liposome-based delivery system for vaccine candidates: constructing an effective formulation

2012

Journal Article

Effect of polymer grafting density on silica nanoparticle toxicity

Lin, I-Chun, Liang, Mingtao, Liu, Tzu-Yu, Jia, Zhongfan, Monteiro, Michael J. and Toth, Istvan (2012). Effect of polymer grafting density on silica nanoparticle toxicity. Bioorganic & Medicinal Chemistry, 20 (23), 6862-6869. doi: 10.1016/j.bmc.2012.09.045

Effect of polymer grafting density on silica nanoparticle toxicity

2012

Journal Article

Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives

Varamini, Pegah, Hussein, Waleed M., Mansfeld, Friederike M. and Toth, Istvan (2012). Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives. Bioorganic & Medicinal Chemistry, 20 (21), 6335-6343. doi: 10.1016/j.bmc.2012.09.003

Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives

2012

Journal Article

Peptide-Based Subunit Vaccine against Hookworm Infection

Skwarczynski, Mariusz, Dougall, Annette M., Khoshnejad, Makan, Chandrudu, Saranya, Pearson, Mark S., Loukas, Alex and Toth, Istvan (2012). Peptide-Based Subunit Vaccine against Hookworm Infection. PLoS One, 7 (10 Article #e46870) e46870, e46870. doi: 10.1371/journal.pone.0046870

Peptide-Based Subunit Vaccine against Hookworm Infection

2012

Journal Article

Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes

Zaman, Mehfuz, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Ziora, Zyta M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2012). Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes. Journal of Medicinal Chemistry, 55 (19), 8515-8523. doi: 10.1021/jm301074n

Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes

2012

Journal Article

Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration

Mansfeld, Friederike M. and Toth, Istvan (2012). Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration. International Journal of Pharmaceutics, 439 (1-2), 216-222. doi: 10.1016/j.ijpharm.2012.09.038

Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration

2012

Journal Article

Peptides as therapeutics with enhanced bioactivity

Goodwin, D., Simerska, P. and Toth, I. (2012). Peptides as therapeutics with enhanced bioactivity. Current Medicinal Chemistry, 19 (26), 4451-4461. doi: 10.2174/092986712803251548

Peptides as therapeutics with enhanced bioactivity

2012

Journal Article

Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.

Apte, Simon H., Groves, Penny L., Skwarczynski, Mariusz, Fujita, Yoshio, Chang, Chenghung, Toth, Istvan and Doolan, Denise L. (2012). Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.. PLoS One, 7 (8 Article. No.e40928) e40928, e40928. doi: 10.1371/journal.pone.0040928

Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.

2012

Journal Article

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012). Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 (8 Article. No.e41909) e41909, e41909. doi: 10.1371/journal.pone.0041909

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation

2012

Journal Article

Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based toll-like receptor 2 ligand

Abdel-Aal, Abu-Baker M., El-Naggar, Dina, Zaman, Mehfuz, Batzloff, Michael and Toth, Istvan (2012). Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based toll-like receptor 2 ligand. Journal of Medicinal Chemistry, 55 (15), 6968-6974. doi: 10.1021/jm300822g

Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based toll-like receptor 2 ligand

Current funding

  • 2024 - 2027
    A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2027
    Paving the way for a Clinical Vaccine Candidate against Hookworm Infection
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Past funding

  • 2023 - 2024
    The evaluation of a self-adjuvanting oral GnRH vaccine in feral pigs (wild boar)
    Istituto Zooprofilattico Sperimentale del Mezzogiorno
    Open grant
  • 2021 - 2024
    Poly(amino acids) as immune stimulators
    ARC Discovery Projects
    Open grant
  • 2021 - 2025
    A single-shot anti-fertility vaccine in female cattle
    Meat & Livestock Australia
    Open grant
  • 2020 - 2024
    Developing a multicomponent platform for targeted gene delivery
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    Hookworm peptide therapeutic for oral treatment of IBD (NHMRC Development Grant administered by James Cook University)
    James Cook University
    Open grant
  • 2018 - 2022
    Tropical diseases: Translating discoveries into better health (NHMRC Program Grant administered by UniMelb)
    University of Melbourne
    Open grant
  • 2017 - 2019
    Understanding the myometrial transition at term and preterm labour to guide tocolysis (NHMRC Project Grant led by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    The insulin receptor: an Achilles' heel target for successful schistosome vaccine development (AID UQ-QIMR seed grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2016
    Development of a multicomponent delivery system for oligonucleotides
    ARC Discovery Projects
    Open grant
  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2011
    Travel grant for Mr Mehfuz Zaman, PhD Candidate, to attend the 22nd American Peptide Symposium, June 25-30 2011 at San Diego, U.S.
    National Heart Foundation of Australia
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2015
    Liposaccharide based peptide and vaccine delivery systems: Improving the bioavailability and immunogenicity of Luteinizing Hormone-Releasing Hormone
    ARC Discovery Projects
    Open grant
  • 2010 - 2013
    Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
    ARC Discovery Projects
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    UQ Travel Awards Category 1, Francis Szoka
    UQ Travel Grants Scheme
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2008 - 2010
    New neuropathic pain drugs
    NHMRC Development Grant
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008 - 2013
    Immunity and pathogenesis in Tropical and Infectious Diseases: Implications for Vaccines and Drug Development (Program Grant Administered by NHMRC)
    Queensland Institute of Medical Research
    Open grant
  • 2008 - 2010
    Synthesis, Biological Interactions and Toxicity Studies of Precisely Engineered Nanoparticles
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007 - 2009
    Two-photon microscopy of albumin handling by the intact kidney
    NHMRC Project Grant
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Charged Liposaccharide Based Drug Delivery System
    ARC Discovery Projects
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2009
    Global GAS vaccine based on the M-protein
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2009
    Global GAS vaccine based on the M-protein
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2005
    Biological membrane transporters:  Delivery of an oligonucleotide inhibitor of vascular endothelial growth factor (VEGF)
    NHMRC Development Grant
    Open grant
  • 2004 - 2008
    NHMRC PROGRAM GRANT: Tropical infectious diseases - pathogenesis and vaccine research
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Synthesis Of Glycopeptide CNS Drug Candidates Applying Chemical And Chemo-Enzymatic Methods
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2006
    A combinatorial approach to creation of new epitopes with biological activity
    ARC Linkage Projects
    Open grant
  • 2003
    A Multiple Antigen Lipophilic Adjuvant Carrier (MALAC) System
    NHMRC Project Grant
    Open grant
  • 2003
    Delivery Technologies For Novel Sub-Unit Antigens
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Delivery Technologies for Novel Synthetic Peptide Antigens
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Malvern Zetasizer 3000HS
    NHMRC Equipment Grant
    Open grant
  • 2002 - 2005
    Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery.
    ARC Linkage Projects
    Open grant
  • 2001 - 2002
    NHMRC Equipment Grant 2000
    NHMRC Equipment Grant
    Open grant
  • 2001 - 2002
    Travel grant for travel on Scientific Visits to Europe
    Australian Academy of Science
    Open grant
  • 2001 - 2003
    Application of Saccharides in Immunology - Immunoadjuvants and Vaccines
    Alchemia Pty Ltd
    Open grant
  • 2001 - 2003
    Charged Liposaccharides for Drug Delivery
    Alchemia Pty Ltd
    Open grant
  • 2001 - 2004
    Lipid and liposaccharide based drug delivery systems
    Wellcome Trust
    Open grant
  • 2001
    A biohazard laminar flow hood for neuronal cell cultures:partial cost recovery from emergency purchase
    Brain Research Fund
    Open grant
  • 2001 - 2003
    Charged Lipophilic Dendrimers: Delivery of Oligonucleotides with Therapeutic Potential
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    A novel lipidic adjuvant carrier system for vaccination including vaccintation via the oral route
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Targeting alpha-conotoxin MII to inhibit neuronal nicotinic acetycholine alpha3beta2 receptors of the central nervous system
    NHMRC Project Grant
    Open grant
  • 1999 - 2002
    A novel liposaccharide based system for drug/peptide delivery
    Wellcome Trust
    Open grant
  • 1999 - 2001
    Development of synthetic methods for the commercial production of sialic acid containing carbohydrates
    Alchemia Pty Ltd
    Open grant
  • 1999 - 2001
    Development of synthetic methods for the commercial production of sialic acid containing carbohydrates
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 1999
    Lipidic peptides
    Cortecs International
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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