Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

241 - 260 of 683 works

2014

Journal Article

Preface

Toth, Istvan (2014). Preface. Current Drug Delivery, 11 (1), 1-1. doi: 10.2174/156720181101140212161054

Preface

2013

Journal Article

Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain

Varamini, Pegah and Toth, Istvan (2013). Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain. Frontiers in Pharmacology, 4 (155) Article 155, 1-7. doi: 10.3389/fphar.2013.00155

Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain

2013

Journal Article

Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery.

Eskandari, Sharareh, Varamini, Pegah and Toth, Istvan (2013). Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery.. Journal of Liposome Research, 23 (4), 311-317. doi: 10.3109/08982104.2013.805339

Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery.

2013

Journal Article

ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2013). ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery. ChemInform, 44 (43), no-no. doi: 10.1002/chin.201343267

ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery

2013

Journal Article

Feherje alapu vedooltasok nanotechnologiaval

Toth, Istvan, Zaman, Mehfuz and Skwarczynski, Mariusz (2013). Feherje alapu vedooltasok nanotechnologiaval. Termézet Világa, 144 (11), 504-508.

Feherje alapu vedooltasok nanotechnologiaval

2013

Journal Article

Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure-activity relationships

Zaman, Mehfuz and Toth, Istvan (2013). Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure-activity relationships. Frontiers in Immunology, 4 (318) Article 318, 1-12. doi: 10.3389/fimmu.2013.00318

Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure-activity relationships

2013

Journal Article

An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system

Moyle, Peter M., Hartas, Jon, Henningham, Anna, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013). An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system. Nanomedicine: Nanotechnology, Biology and Medicine, 9 (7), 935-944. doi: 10.1016/j.nano.2013.01.009

An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system

2013

Journal Article

Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system

Simerska, Pavla, Ziora, Zyta Maria, Fagan, Vincent, Goodwin, Daryn, Edrous, Farrah and Toth, Istvan (2013). Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system. Drug Delivery and Translational Research, Online First (3), 1-10. doi: 10.1007/s13346-013-0173-8

Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system

2013

Journal Article

alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, Pavla, Christie, Michelle P., Goodwin, Daryn, Jen, Freda E.-C., Jennings, Michael P. and Toth, Istvan (2013). alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins. Journal of Molecular Catalysis B: Enzymatic, In Press, Accepted Manuscript, 1-28. doi: 10.1016/j.molcatb.2013.08.018

alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

2013

Journal Article

Liposomes for improved enzymatic glycosylation of lipid-modified lactose enkephalin

Christie, Michelle P., Simerska, Pavla, Jen, Freda E.-C., Jennings, Michael P. and Toth, Istvan (2013). Liposomes for improved enzymatic glycosylation of lipid-modified lactose enkephalin. ChemPlusChem, 78 (8), 793-796. doi: 10.1002/cplu.201300115

Liposomes for improved enzymatic glycosylation of lipid-modified lactose enkephalin

2013

Journal Article

Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH)

Moradi, Shayli Varasteh, Mansfeld, Friederike M. and Toth, Istvan (2013). Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH). Bioorganic and Medicinal Chemistry, 21 (14), 4259-4265. doi: 10.1016/j.bmc.2013.04.068

Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH)

2013

Journal Article

Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer

Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013). Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 (8), 2798-2806. doi: 10.1021/bm400626w

Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer

2013

Journal Article

pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform

Skwarczynski, Mariusz, Kowapradit, Jariya, Ziora, Zyta Maria and Toth, Istvan (2013). pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform. Biochemical Compounds, 1. doi: 10.7243/2052-9341-1-2

pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform

2013

Journal Article

Endomorphin derivatives with improved pharmacological properties

Varamini, Pegah, Blanchfield, Joanne T. and Toth, Istvan (2013). Endomorphin derivatives with improved pharmacological properties. Current Medicinal Chemistry, 20 (22), 2741-2758. doi: 10.2174/0929867311320220002

Endomorphin derivatives with improved pharmacological properties

2013

Journal Article

Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy

Chen, Ying-Shan, Toth, Istvan, Danesh-Meyer, Helen V., Green, Colin R. and Rupenthal, Ilva D. (2013). Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy. Journal of Pharmaceutical Sciences, 102 (7), 2322-2331. doi: 10.1002/jps.23617

Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy

2013

Journal Article

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

Deng, Zhou J., Liang, Mingtao, Toth, Istvan, Monteiro, Michael and Minchin, Rodney F. (2013). Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses. Nanotoxicology, 7 (3), 314-322. doi: 10.3109/17435390.2012.655342

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

2013

Journal Article

Nanovaccines and their mode of action

Zaman, Mehfuz, Good, Michael F. and Toth, Istvan (2013). Nanovaccines and their mode of action. Methods, 60 (3), 226-231. doi: 10.1016/j.ymeth.2013.04.014

Nanovaccines and their mode of action

2013

Journal Article

Chemical methods for peptide and protein production

Chandrudu, Saranya, Simerska, Pavla and Toth, Istvan (2013). Chemical methods for peptide and protein production. Molecules, 18 (4), 4373-4388. doi: 10.3390/molecules18044373

Chemical methods for peptide and protein production

2013

Journal Article

Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation

Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013). Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 (7), 1898-1904. doi: 10.1016/j.bmc.2013.01.044

Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation

2013

Journal Article

Modern subunit vaccines: development, components, and research opportunities

Moyle, Peter Michael and Toth, Istvan (2013). Modern subunit vaccines: development, components, and research opportunities. ChemMedChem, 8 (3), 360-376. doi: 10.1002/cmdc.201200487

Modern subunit vaccines: development, components, and research opportunities

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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