Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

181 - 200 of 683 works

2016

Book Chapter

The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection

Ahmad Fuaad, Abdullah A. H., Skwarczynski, Mariusz and Toth, Istvan (2016). The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection. Vaccine design: methods and protocols: volume 1: vaccines for human diseases. (pp. 639-653) edited by Thomas, Sunil. New York, NY United States: Springer New York. doi: 10.1007/978-1-4939-3387-7_36

The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection

2016

Journal Article

Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria

Chandrudu, Saranya, Skwarczynski, Mariusz, Pattinson, David, Apte, Simon H., Doolan, Denise L. and Toth, Istvan (2016). Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria. Biochemical Compounds, 4 (1). doi: 10.7243/2052-9341-4-1

Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria

2016

Book Chapter

Introduction

Skwarczynski, Mariusz and Toth, Istvan (2016). Introduction. Micro and nanotechnology in vaccine development: micro and nano technologies. (pp. xvii-xviii) edited by Mariusz Skwarczynski and Istvan Toth. Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00027-0

Introduction

2015

Journal Article

Luteinizing hormone releasing hormone/galactose core/lipopeptide

Simerska, Pavla, Lai, Hoi Ling and Toth, Istvan (2015). Luteinizing hormone releasing hormone/galactose core/lipopeptide. MolBank, 2015 (4) M881, M881. doi: 10.3390/M881

Luteinizing hormone releasing hormone/galactose core/lipopeptide

2015

Journal Article

Meet our editorial board member

Toth, Istvan (2015). Meet our editorial board member. Mini-Reviews in Medicinal Chemistry, 15 (14), 1131-1131. doi: 10.2174/138955751514151006154835

Meet our editorial board member

2015

Journal Article

Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors

Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015). Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5570-5575. doi: 10.1016/j.bmcl.2015.10.049

Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors

2015

Journal Article

The cytolethal distending toxin-IV cdt coding region in an avian pathogenic Escherichia coli (APEC) strain shows instability and irregular excision pattern

Tóth, István and Schneider, György (2015). The cytolethal distending toxin-IV cdt coding region in an avian pathogenic Escherichia coli (APEC) strain shows instability and irregular excision pattern. Acta Microbiologica et Immunologica Hungarica, 62 (4), 423-433. doi: 10.1556/030.62.2015.4.7

The cytolethal distending toxin-IV cdt coding region in an avian pathogenic Escherichia coli (APEC) strain shows instability and irregular excision pattern

2015

Journal Article

Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin

Eskandari, Sharareh, Stephenson, Rachel J., Fuaad, Abdullah Ahmad, Apte, Simon H., Doolan, Denise L. and Toth, Istvan (2015). Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin. Chemistry - A European Journal, 21 (3), 1251-1261. doi: 10.1002/chem.201404997

Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin

2015

Journal Article

In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue

Varasteh Moradi, Shayli, Varamini, Pegah, Steyn, Frederik and Toth, Istvan (2015). In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue. International Journal of Pharmaceutics, 495 (1), 106-111. doi: 10.1016/j.ijpharm.2015.08.095

In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue

2015

Journal Article

Recent advances in the development of subunit-based RSV vaccines.

Jaberolansar, Noushin, Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2015). Recent advances in the development of subunit-based RSV vaccines.. Expert Review of Vaccines, 15 (1), 53-68. doi: 10.1586/14760584.2016.1105134

Recent advances in the development of subunit-based RSV vaccines.

2015

Journal Article

A study on the encapsulation of an occludin lipophilic derivative in liposomal carriers

Cupri, Sarha, Graziano, Adriana C. E., Cardile, Venera, Skwarczynski, Mariusz, Toth, Istvan and Pignatello, Rosario (2015). A study on the encapsulation of an occludin lipophilic derivative in liposomal carriers. Journal of Liposome Research, 25 (4), 287-293. doi: 10.3109/08982104.2014.992025

A study on the encapsulation of an occludin lipophilic derivative in liposomal carriers

2015

Journal Article

Lipopeptide nanoparticles: development of vaccines against hookworm parasite

Fuaad, Abdullah A. H. Ahmad, Pearson, Mark S., Pickering, Darren A., Becker, Luke, Zhao, Guangzu, Loukas, Alex C., Skwarczynski, Mariusz and Toth, Istvan (2015). Lipopeptide nanoparticles: development of vaccines against hookworm parasite. ChemMedChem, 10 (10), 1647-1654. doi: 10.1002/cmdc.201500227

Lipopeptide nanoparticles: development of vaccines against hookworm parasite

2015

Journal Article

Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia

Chen, Ying-Shan, Green, Colin R., Teague, Rebecca, Perrett, Joshua, Danesh-Meyer, Helen V., Toth, Istvan and Rupenthal, Ilva D. (2015). Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia. Drug Delivery and Translational Research, 5 (5), 480-488. doi: 10.1007/s13346-015-0249-8

Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia

2015

Journal Article

Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015)

Fuaad, Abdullah A. H. Ahmad, Pearson, Mark S., Pickering, Darren A., Becker, Luke, Zhao, Guangzu, Loukas, Alex C., Skwarczynski, Mariusz and Toth, Istvan (2015). Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015). ChemMedChem, 10 (10), 1768-1768. doi: 10.1002/cmdc.201500390

Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015)

2015

Journal Article

Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems

Wan, Yu, Moyle, Peter M and Toth, Istvan (2015). Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems. Current Medicinal Chemistry, 22 (29), 3326-3346. doi: 10.2174/0929867322666150825162941

Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems

2015

Journal Article

Meet our editor

Toth, Istvan (2015). Meet our editor. Medicinal Chemistry, 11 (5), 415-415. doi: 10.2174/157340641105150630122633

Meet our editor

2015

Journal Article

Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons

Rosli, Nurlina, Christie, Michelle, Moyle, Peter M. and Toth, Istvan (2015). Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons. Bioorganic & Medicinal Chemistry, 23 (10), 2470-2479. doi: 10.1016/j.bmc.2015.03.058

Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons

2015

Journal Article

Evaluation of the biological properties and the enzymatic stability of glycosylated luteinizing hormone-releasing hormone analogs

Moradi, Shayli Varasteh, Varamini, Pegah and Toth, Istvan (2015). Evaluation of the biological properties and the enzymatic stability of glycosylated luteinizing hormone-releasing hormone analogs. AAPS Journal, 17 (5), 1135-1143. doi: 10.1208/s12248-015-9769-x

Evaluation of the biological properties and the enzymatic stability of glycosylated luteinizing hormone-releasing hormone analogs

2015

Journal Article

Investigation of structure–activity relationships of synthetic anti-gonadotropin releasing hormone vaccine candidates

Chang, Chenghung, Varamini, Pegah, Giddam, Ashwini Kumar, Mansfeld, Friederike M., D'Occhio, Michael J. and Toth, Istvan (2015). Investigation of structure–activity relationships of synthetic anti-gonadotropin releasing hormone vaccine candidates. ChemMedChem, 10 (5), 901-910. doi: 10.1002/cmdc.201500036

Investigation of structure–activity relationships of synthetic anti-gonadotropin releasing hormone vaccine candidates

2015

Journal Article

Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries)

Goodwin, Daryn, Varamini, Pegah, Simerska, Pavla, D'Occhio, Michael J. and Toth, Istvan (2015). Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries). Vaccine, 33 (12), 1453-1458. doi: 10.1016/j.vaccine.2015.01.076

Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries)

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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