Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

161 - 180 of 683 works

2016

Journal Article

Linear and branched polyacrylates as a delivery platform for peptide-based vaccines

Chandrudu, Saranya, Bartlett, Stacey, Khalil, Zeinab G., Jia, Zhongfan, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2016). Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery, 7 (9), 601-609. doi: 10.4155/tde-2016-0037

Linear and branched polyacrylates as a delivery platform for peptide-based vaccines

2016

Journal Article

A study on liposomal encapsulation of a lipophilic prodrug of LHRH

Pignatello, Rosario, Musumeci, Teresa, Graziano, Adriana C. E., Lo Furno, Debora, Varamini, Pegah, Mansfeld, Friederike M., Cardile, Venera and Toth, Istvan (2016). A study on liposomal encapsulation of a lipophilic prodrug of LHRH. Pharmaceutical Development and Technology, 21 (6), 664-671. doi: 10.3109/10837450.2015.1041045

A study on liposomal encapsulation of a lipophilic prodrug of LHRH

2016

Journal Article

Identification of host insulin binding sites on Schistosoma japonicum insulin receptors

Stephenson, Rachel J., Toth, Istvan, Liang, Jiening, Mangat, Amanjot, McManus, Donald P. and You, Hong (2016). Identification of host insulin binding sites on Schistosoma japonicum insulin receptors. PLoS One, 11 (7) e0159704, e0159704. doi: 10.1371/journal.pone.0159704

Identification of host insulin binding sites on Schistosoma japonicum insulin receptors

2016

Journal Article

Peptide-based multicomponent oligonucleotide delivery systems: optimisation of poly-l-lysine dendrons for plasmid DNA delivery

Kamaruzaman, Khairul A., Moyle, Peter M. and Toth, Istvan (2016). Peptide-based multicomponent oligonucleotide delivery systems: optimisation of poly-l-lysine dendrons for plasmid DNA delivery. International Journal of Peptide Research and Therapeutics, 23 (1), 1-16. doi: 10.1007/s10989-016-9545-5

Peptide-based multicomponent oligonucleotide delivery systems: optimisation of poly-l-lysine dendrons for plasmid DNA delivery

2016

Journal Article

Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models

Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16

Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models

2016

Journal Article

Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053

Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

2016

Journal Article

Synthesis of glycolipid-based drug delivery systems for oral administration

Lee, Wan Ling, Toth, Istvan and Simerska, Pavla (2016). Synthesis of glycolipid-based drug delivery systems for oral administration. Drug Delivery Letters, 6 (1), 38-45. doi: 10.2174/2210303106666160506155139

Synthesis of glycolipid-based drug delivery systems for oral administration

2016

Journal Article

Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus

Marasini, Nirmal, Giddam, Ashwini K., Ghaffar, Khairunnisa A., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus. Nanomedicine, 11 (10), 1223-1236. doi: 10.2217/nnm.16.36

Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus

2016

Journal Article

Liposome-based intranasal Delivery of lipopeptide vaccine candidates against Group A Streptococcus

Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Giddam, Ashwini K., Batzloff, Michael, Good, Michael, Skwarczynski, Mariusz and Toth, Istvan (2016). Liposome-based intranasal Delivery of lipopeptide vaccine candidates against Group A Streptococcus. Acta Biomaterialia, 41, 161-168. doi: 10.1016/j.actbio.2016.04.012

Liposome-based intranasal Delivery of lipopeptide vaccine candidates against Group A Streptococcus

2016

Journal Article

Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity

Wan, Yu, Moyle, Peter M., Christie, Michelle P. and Toth, Istvan (2016). Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity. Nanomedicine, 11 (8), 907-919. doi: 10.2217/nnm.16.27

Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity

2016

Journal Article

Preface

Toth, Istvan (2016). Preface. Current Drug Delivery, 13 (1), 3-3. doi: 10.2174/156720181301160314153150

Preface

2016

Journal Article

Peptide-based synthetic vaccines

Skwarczynski, Mariusz and Toth, Istvan (2016). Peptide-based synthetic vaccines. Chemical Science, 7 (2), 842-854. doi: 10.1039/c5sc03892h

Peptide-based synthetic vaccines

2016

Journal Article

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2016). Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chemical Science, 7 (4), 2492-2500. doi: 10.1039/C5SC04392A

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

2016

Journal Article

Synthesis of mannosylated lipopeptides with receptor targeting properties

Sedaghat, Bita, Stephenson, Rachel J., Giddam, Ashwini Kumar, Eskandari, Sharareh, Apte, Simon H., Pattinson, David J., Doolan, Denise L. and Toth, Istvan (2016). Synthesis of mannosylated lipopeptides with receptor targeting properties. Bioconjugate Chemistry, 27 (3), 533-548. doi: 10.1021/acs.bioconjchem.5b00547

Synthesis of mannosylated lipopeptides with receptor targeting properties

2016

Journal Article

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2016). Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines. Chemical Science, 7 (3), 2308-2321. doi: 10.1039/C5SC03859F

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

2016

Book Chapter

Középosztály(ok) Magyarországon és Európában

Tóth, István György (2016). Középosztály(ok) Magyarországon és Európában. Társadalmi Riport. (pp. 75-97) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2016.4

Középosztály(ok) Magyarországon és Európában

2016

Journal Article

Recent advances in oral delivery of peptide hormones

Varamini, Pegah and Toth, Istvan (2016). Recent advances in oral delivery of peptide hormones. Expert Opinion on Drug Delivery, 13 (4), 507-522. doi: 10.1517/17425247.2016.1142526

Recent advances in oral delivery of peptide hormones

2016

Journal Article

Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses

Apte, Simon H., Stephenson, Rachel J., Simerska, Pavla, Groves, Penny L., Aljohani, Salwa, Eskandari, Sharareh, Toth, Istvan and Doolan, Denise L. (2016). Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses. Nanomedicine, 11 (2), 137-152. doi: 10.2217/nnm.15.184

Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses

2016

Book Chapter

Current boundaries in the formulation of lipid based delivery systems

Eskandari, Sharareh, Stephenson, Rachel and Toth, Istvan (2016). Current boundaries in the formulation of lipid based delivery systems. Liposomal delivery systems: advances and challenges. (pp. 160-174) edited by Abdus Samad, Sarwar Beg and Iram Nazish. London, United Kingdom: Future Medicine. doi: 10.4155/9781910419083

Current boundaries in the formulation of lipid based delivery systems

2016

Journal Article

Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates

Chan, Amy, Hussein, Waleed M., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Mostafa, Ahmed, Eskandari, Sharareh, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorganic and Medicinal Chemistry, 24 (14), 3095-3101. doi: 10.1016/j.bmc.2016.03.063

Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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