Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

221 - 240 of 683 works

2014

Journal Article

The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in Caco-2 cell model: contributions of glucose transporters and efflux systems

Moradi, Shayli Varasteh, Varamini, Pegah and Toth, Istvan (2014). The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in Caco-2 cell model: contributions of glucose transporters and efflux systems. Journal of Pharmaceutical Sciences, Early View (10), 3217-3224. doi: 10.1002/jps.24120

The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in Caco-2 cell model: contributions of glucose transporters and efflux systems

2014

Journal Article

Oral delivery of nanoparticle-based vaccines

Marasini, Nirmal, Skwarczynski, Mariusz and Toth, Istvan (2014). Oral delivery of nanoparticle-based vaccines. Expert Review of Vaccines, Early Online (11), 1361-1376. doi: 10.1586/14760584.2014.936852

Oral delivery of nanoparticle-based vaccines

2014

Journal Article

Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold

Fagan, Vincent, Toth, Istvan and Simerska, Pavla (2014). Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold. Beilstein Journal of Organic Chemistry, 10 (1), 1741-1748. doi: 10.3762/bjoc.10.181

Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold

2014

Journal Article

Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro

Stephenson, Rachel, Varamini, Pegah, Butcher, Neville, Minchin, Rodney and Toth, Istvan (2014). Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 10 (8), 1799-1808. doi: 10.1016/j.nano.2014.06.015

Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro

2014

Journal Article

Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group A streptococcal vaccines

Moyle, Peter M., Dai, Wei, Zhang, Yingkai, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2014). Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group A streptococcal vaccines. Bioconjugate Chemistry, 25 (5), 965-978. doi: 10.1021/bc500108b

Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group A streptococcal vaccines

2014

Journal Article

Calorimetry and Langmuir-Blodgett studies on the interaction of a lipophilic prodrug of LHRH with biomembrane models

Sarpietro, Maria G., Accolla, Maria L., Santoro, Nancy, Mansfeld, Friederike M., Pignatello, Rosario, Toth, Istvan and Castelli, Francesco (2014). Calorimetry and Langmuir-Blodgett studies on the interaction of a lipophilic prodrug of LHRH with biomembrane models. Journal of Colloid and Interface Science, 421, 122-131. doi: 10.1016/j.jcis.2014.01.040

Calorimetry and Langmuir-Blodgett studies on the interaction of a lipophilic prodrug of LHRH with biomembrane models

2014

Journal Article

Liposomes as Nanovaccine Delivery Systems

Ghaffar, Khairunnisa Abdul, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2014). Liposomes as Nanovaccine Delivery Systems. Current Topics in Medicinal Chemistry, 14 (9), 1194-1208. doi: 10.2174/1568026614666140329232757

Liposomes as Nanovaccine Delivery Systems

2014

Journal Article

Use of virulence determinants and seropathotypes to distinguish high- and low-risk Escherichia coli O157 and non-O157 isolates from Europe

Anjum, M. F., Jones, E., Morrison, V., Tozzoli, R., Morabito, S., Toth, I., Nagy, B., Smith, G., Aspan, A., Nielsen, E. M., Fach, P., Herrera-León, S., Woodward, M. J. and La Ragione, R. M. (2014). Use of virulence determinants and seropathotypes to distinguish high- and low-risk Escherichia coli O157 and non-O157 isolates from Europe. Epidemiology and Infection, 142 (5), 1019-1028. doi: 10.1017/S0950268813001635

Use of virulence determinants and seropathotypes to distinguish high- and low-risk Escherichia coli O157 and non-O157 isolates from Europe

2014

Journal Article

A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation

Christie, Michelle P., Simerská, Pavla, Jen, Freda E.-C., Hussein, Waleed M., Rawi, Mohamad F. M., Hartley-Tassell, Lauren E., Day, Christopher J., Jennings, Michael P. and Toth, Istvan (2014). A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. PLoS One, 9 (4) e95024, e95024.1-e95024.10. doi: 10.1371/journal.pone.0095024

A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation

2014

Journal Article

Toll-like receptor agonists: a patent review (2011 - 2013)

Hussein, Waleed M., Liu, Tzu-Yu, Skwarczynski, Mariusz and Toth, Istvan (2014). Toll-like receptor agonists: a patent review (2011 - 2013). Expert Opinion on Therapeutic Patents, 24 (4), 453-470. doi: 10.1517/13543776.2014.880691

Toll-like receptor agonists: a patent review (2011 - 2013)

2014

Journal Article

Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway

Cros, Cécile D., Toth, Istvan and Blanchfield, Joanne T. (2014). Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway. Bioorganic and Medicinal Chemistry Letters, 24 (5), 1373-1375. doi: 10.1016/j.bmcl.2014.01.041

Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway

2014

Journal Article

Recent progress in adjuvant discovery for peptide-based subunit vaccines

Azmi, Fazren, Fuaad, Abdullah Al Hadi Ahmad, Skwarczynski, Mariusz and Toth, Istvan (2014). Recent progress in adjuvant discovery for peptide-based subunit vaccines. Human Vaccines and Immunotherapeutics, 10 (3), 778-796. doi: 10.4161/hv.27332

Recent progress in adjuvant discovery for peptide-based subunit vaccines

2014

Journal Article

Self-assembled peptide-polymer conjugates as vaccines

Liu, Tzu-Yu, Fuaad, Abdullah Al-Hadi Ahmad, Toth, Istvan and Skwarczynski, Mariusz (2014). Self-assembled peptide-polymer conjugates as vaccines. Chimica Oggi - Chemistry Today, 32 (2 (Supplement)), 18-22.

Self-assembled peptide-polymer conjugates as vaccines

2014

Journal Article

The immune system likes nanotechnology

Toth, Istvan and Skwarczynski, Mariusz (2014). The immune system likes nanotechnology. Nanomedicine, 9 (17), 2607-2609. doi: 10.2217/nnm.14.199

The immune system likes nanotechnology

2014

Journal Article

Editorial (Thematic issue: nanotechnology for drug delivery applications)

Toth, Istvan (2014). Editorial (Thematic issue: nanotechnology for drug delivery applications). Current Drug Delivery, 11 (6), 665-665. doi: 10.2174/156720181106141202112943

Editorial (Thematic issue: nanotechnology for drug delivery applications)

2014

Journal Article

Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses

Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014). Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 (37), 4743-4750. doi: 10.1016/j.vaccine.2014.06.049

Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses

2014

Conference Publication

Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide

Moradi, S. V., Varamini, P. and Toth, I. (2014). Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide. Dr. Bert L. Schram Young Investigators' Mini-Symposium. 33EPS 2014: 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August-5 September, 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2686

Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide

2014

Journal Article

Preface

Toth, Istvan (2014). Preface. Current Drug Delivery, 11 (1), 1-1. doi: 10.2174/156720181101140212161054

Preface

2014

Journal Article

Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine

Dougall, Annette M., Skwarczynski, Mariusz, Khoshnejad, Makan, Chandrudu, Saranya, Daly, Norelle L., Toth, Istvan and Loukas, Alex (2014). Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine. Human Vaccines and Immunotherapeutics, 10 (2), 399-409. doi: 10.4161/hv.27057

Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine

2014

Journal Article

Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine

Ahmad Fuaad, Abdullah A. H., Jia, Zhongfan, Hartas, Jon, Ziora, Zyta M., Lin, I-Chun, Moyle, Peter M., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2014). Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine, 9 (1), 35-43. doi: 10.2217/NNM.13.7

Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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