Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

101 - 120 of 683 works

2020

Journal Article

Lipids as activators of innate immunity in peptide vaccine delivery

Bartlett, Stacey, Skwarczynski, Mariusz and Toth, Istvan (2020). Lipids as activators of innate immunity in peptide vaccine delivery. Current Medicinal Chemistry, 25 (17), 2887-2901. doi: 10.2174/0929867325666181026100849

Lipids as activators of innate immunity in peptide vaccine delivery

2020

Book Chapter

Preface

Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Preface. Peptide synthesis: methods and protocols. (pp. v-v) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer.

Preface

2019

Book

Peptide synthesis: methods and protocols

Waleed Hussein, Mariusz Skwarczynski and Istvan Toth eds. (2019). Peptide synthesis: methods and protocols. New York, NY USA: Humana New York. doi: 10.1007/978-1-0716-0227-0

Peptide synthesis: methods and protocols

2019

Journal Article

Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Low, Leanne M., Liu, Xue Q., Ho, Mei-Fong, Zaman, Mehfuz, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice. Vaccine, 38 (6), 1494-1504. doi: 10.1016/j.vaccine.2019.11.063

Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

2019

Journal Article

Polyelectrolyte-based platforms for the delivery of peptides and proteins

Zhao, Lili, Skwarczynski, Mariusz and Toth, Istvan (2019). Polyelectrolyte-based platforms for the delivery of peptides and proteins. ACS Biomaterials Science & Engineering, 5 (10) acsbiomaterials.9b01135, 4937-4950. doi: 10.1021/acsbiomaterials.9b01135

Polyelectrolyte-based platforms for the delivery of peptides and proteins

2019

Journal Article

Cell-penetrating peptides in vaccine delivery: facts, challenges and perspectives

Skwarczynski, Mariusz and Toth, Istvan (2019). Cell-penetrating peptides in vaccine delivery: facts, challenges and perspectives. Therapeutic Delivery, 10 (8), 465-467. doi: 10.4155/tde-2019-0042

Cell-penetrating peptides in vaccine delivery: facts, challenges and perspectives

2019

Journal Article

Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus

Azuar, Armira, Zhao, Lili, Hei, Tsui Ting, Nevagi, Reshma J., Bartlett, Stacey, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Skwarczynski, Mariusz (2019). Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus. ACS Medicinal Chemistry Letters, 10 (9) acsmedchemlett.9b00239, 1253-1259. doi: 10.1021/acsmedchemlett.9b00239

Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus

2019

Journal Article

Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach

Prokai-Tatrai, Katalin, De La Cruz, Daniel L., Nguyen, Vien, Ross, Benjamin P., Toth, Istvan and Prokai, Laszlo (2019). Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach. Pharmaceutics, 11 (7) 349, 349. doi: 10.3390/pharmaceutics11070349

Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach

2019

Journal Article

Peptide-based targeted polymeric nanoparticles for siRNA delivery

Hussein, Waleed M., Cheong, Yee S., Liu, Chang, Liu, Genan, Begum, Anjuman Ara, Attallah, Maria Adly, Moyle, Peter Michael, Torchilin, Vladimir, Smith, Roger and Toth, Istvan (2019). Peptide-based targeted polymeric nanoparticles for siRNA delivery. Nanotechnology, 30 (41) 415604, 415604. doi: 10.1088/1361-6528/ab313d

Peptide-based targeted polymeric nanoparticles for siRNA delivery

2019

Journal Article

Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system

Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system. Bioorganic and Medicinal Chemistry, 27 (14), 3082-3088. doi: 10.1016/j.bmc.2019.05.033

Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system

2019

Journal Article

Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus

Azuar, Armira, Jin, Wanli , Mukaida, Saori, Hussein, Waleed , Toth, Istvan and Skwarczynski, Mariusz (2019). Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus. Vaccines, 7 (3) 58, 58. doi: 10.3390/vaccines7030058

Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus

2019

Journal Article

Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system

Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system. European Journal of Medicinal Chemistry, 179, 100-108. doi: 10.1016/j.ejmech.2019.06.047

Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system

2019

Journal Article

Advances in targeted gene delivery

Begum, Anjuman A., Toth, Istvan, Hussein, Waleed M. and Moyle, Peter Michael (2019). Advances in targeted gene delivery. Current Drug Delivery, 16 (7), 588-608. doi: 10.2174/1567201816666190529072914

Advances in targeted gene delivery

2019

Journal Article

Gastrin-releasing peptide receptor-targeted hybrid peptide/phospholipid pDNA/siRNA delivery systems

Begum, Anjuman A., Toth, Istvan and Moyle, Peter M. (2019). Gastrin-releasing peptide receptor-targeted hybrid peptide/phospholipid pDNA/siRNA delivery systems. Nanomedicine, 14 (9), 1153-1171. doi: 10.2217/nnm-2018-0380

Gastrin-releasing peptide receptor-targeted hybrid peptide/phospholipid pDNA/siRNA delivery systems

2019

Journal Article

Polymers for subunit vaccine delivery

Nevagi, Reshma J., Skwarczynski, Mariusz and Toth, Istvan (2019). Polymers for subunit vaccine delivery. European Polymer Journal, 114, 397-410. doi: 10.1016/j.eurpolymj.2019.03.009

Polymers for subunit vaccine delivery

2019

Journal Article

An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model

Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2019). An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model. mBio, 10 (2) e00693-19. doi: 10.1128/mBio.00693-19

An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model

2019

Journal Article

Induction of Plasmodium-specific immune responses using liposome-based vaccines

Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Induction of Plasmodium-specific immune responses using liposome-based vaccines. Frontiers in Immunology, 10 135, 135. doi: 10.3389/fimmu.2019.00135

Induction of Plasmodium-specific immune responses using liposome-based vaccines

2019

Conference Publication

Carbohydrates in vaccine development

Aljohani, Salwa, Hussein, Waleed M., Toth, Istvan and Simerska, Pavla (2019). Carbohydrates in vaccine development. Controlled Release Asia Meeting, Singapore, 24-25 September, 2018. Sharjah, United Arab Emirates: Bentham Science Publishers. doi: 10.2174/1567201816666190702153612

Carbohydrates in vaccine development

2019

Book Chapter

The upper middle class: a new aristocracy? Posing the question for post-communist Hungary

Tóth, István György and Szelényi, Iván (2019). The upper middle class: a new aristocracy? Posing the question for post-communist Hungary. Social Report. (pp. 101-119) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2019.6

The upper middle class: a new aristocracy? Posing the question for post-communist Hungary

2019

Journal Article

Cell-penetrating peptides: efficient vectors for vaccine delivery

Yang, Jieru, Luo, Yacheng, Shibu, Mohini Anjna, Toth, Istvan and Skwarczynski, Mariusz (2019). Cell-penetrating peptides: efficient vectors for vaccine delivery. Current Drug Delivery, 16 (5), 430-443. doi: 10.2174/1567201816666190123120915

Cell-penetrating peptides: efficient vectors for vaccine delivery

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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