Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

121 - 140 of 683 works

2019

Conference Publication

Carbohydrates in vaccine development

Aljohani, Salwa, Hussein, Waleed M., Toth, Istvan and Simerska, Pavla (2019). Carbohydrates in vaccine development. Controlled Release Asia Meeting, Singapore, 24-25 September, 2018. Sharjah, United Arab Emirates: Bentham Science Publishers. doi: 10.2174/1567201816666190702153612

Carbohydrates in vaccine development

2019

Book Chapter

The upper middle class: a new aristocracy? Posing the question for post-communist Hungary

Tóth, István György and Szelényi, Iván (2019). The upper middle class: a new aristocracy? Posing the question for post-communist Hungary. Social Report. (pp. 101-119) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2019.6

The upper middle class: a new aristocracy? Posing the question for post-communist Hungary

2018

Journal Article

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

Khongkow, Mattaka, Liu, Tzu-yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018). Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 (3), 183-193. doi: 10.33218/prnano1(3).181003.1

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

2018

Journal Article

The influence of physicochemical properties of lipopeptide adjuvants on immune response: a rationale for engineering a potent vaccine

Eskandari, Sharareh, Pattinson, David, Stephenson, Rachel J., Groves, Penny L., Apte, Simon H., Sedaghat, Bita, Chandurudu, Saranya, Doolan, Denise L. and Toth, Istvan (2018). The influence of physicochemical properties of lipopeptide adjuvants on immune response: a rationale for engineering a potent vaccine. Chemistry: A European Journal, 24 (39), 9892-9902. doi: 10.1002/chem.201801378

The influence of physicochemical properties of lipopeptide adjuvants on immune response: a rationale for engineering a potent vaccine

2018

Journal Article

Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery

Begum, Anjuman Ara, Wan, Yu, Toth, Istvan and Moyle, Peter M. (2018). Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery. Bioorganic and Medicinal Chemistry, 26 (2), 516-526. doi: 10.1016/j.bmc.2017.12.013

Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery

2018

Book Chapter

Peptide-based vaccines

Nevagi, Reshma J., Toth, Istvan and Skwarczynski, Mariusz (2018). Peptide-based vaccines. Peptide applications in biomedicine, biotechnology and bioengineering. (pp. 327-358) edited by Sotirios Koutsopoulos. Duxford, United Kingdom: Woodhead Publishing (Elsevier). doi: 10.1016/B978-0-08-100736-5.00012-0

Peptide-based vaccines

2018

Book Chapter

Bezáródás és fluiditás a magyar társadalom szerkezetében : Adatolt esszé a felső középosztály bezáródásáról

Tóth, István György and Szelényi, Iván (2018). Bezáródás és fluiditás a magyar társadalom szerkezetében : Adatolt esszé a felső középosztály bezáródásáról. Társadalmi Riport. (pp. 25-46) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2018.2

Bezáródás és fluiditás a magyar társadalom szerkezetében : Adatolt esszé a felső középosztály bezáródásáról

2018

Journal Article

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

Nevagi, Reshma J., Khalil, Zeinab G., Hussein, Waleed M., Powell, Jessica, Batzloff, Michael R., Capon, Robert J., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2018). Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomaterialia, 80, 278-287. doi: 10.1016/j.actbio.2018.09.037

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

2018

Journal Article

Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2

Hussein, Waleed M., Choi, Phil M., Zhang, Cheng, Sierecki, Emma, Johnston, Wayne, Jia, Zhongfan, Monteiro, Michael J., Skwarczynski, Mariusz, Gambin, Yann and Toth, Istvan (2018). Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2. AIMS Allergy and Immunology, 2 (3), 141-147. doi: 10.3934/allergy.2018.3.141

Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2

2017

Journal Article

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

Jaberolansar, Noushin, Chappell, Keith J., Watterson, Daniel, Bermingham, Imogen M., Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2017). Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Scientific Reports, 7 (1) 11130, 11130. doi: 10.1038/s41598-017-10415-w

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

2017

Journal Article

Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity

Varamini, Pegah, Rafiee, Amirreza, Giddam, Ashwini Kumar, Mansfeld, Friederike M., Steyn, Frederik and Toth, Istvan (2017). Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity. Journal of Medicinal Chemistry, 60 (20), 8309-8320. doi: 10.1021/acs.jmedchem.6b01771

Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity

2017

Journal Article

Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection

Schulze, Kai, Ebensen, Thomas, Chandrudu, Saranya, Skwarczynski, Mariusz, Toth, Istvan, Olive, Colleen and Guzman, Carlos A (2017). Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection. Nanomedicine : nanotechnology, biology, and medicine, 13 (8), 2463-2474. doi: 10.1016/j.nano.2017.08.015

Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection

2017

Journal Article

Highly immunogenic trimethyl chitosan-based delivery system for intranasal lipopeptide vaccines against group A streptococcus

Marasini, Nirmal, Ghaffar, Khairunnisa Abdul, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). Highly immunogenic trimethyl chitosan-based delivery system for intranasal lipopeptide vaccines against group A streptococcus. Current Drug Delivery, 14 (5), 701-708. doi: 10.2174/1567201813666160721141322

Highly immunogenic trimethyl chitosan-based delivery system for intranasal lipopeptide vaccines against group A streptococcus

2017

Journal Article

The application of self-assembled nanostructures in peptide-based subunit vaccine development

Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz and Toth, Istvan (2017). The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, 93, 670-681. doi: 10.1016/j.eurpolymj.2017.02.014

The application of self-assembled nanostructures in peptide-based subunit vaccine development

2017

Journal Article

Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells

Wan, Yu, Dai, Wei, Nevagi, Reshma J., Toth, Istvan and Moyle, Peter M. (2017). Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells. Acta Biomaterialia, 59, 257-268. doi: 10.1016/j.actbio.2017.06.032

Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells

2017

Journal Article

Development and delivery of a peptide-based vaccine against group A Streptococcus

Skwarczynski, Mariusz and Toth, Istvan (2017). Development and delivery of a peptide-based vaccine against group A Streptococcus. Infectious Diseases Hub.

Development and delivery of a peptide-based vaccine against group A Streptococcus

2017

Journal Article

Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer

Hussein, Waleed M., Mukaida, Saori, Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2017). Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer. Vaccination Research Open Journal, 1 (1), 39-44. doi: 10.17140/VROJ-1-107

Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer

2017

Journal Article

New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency

Varamini, Pegah, Mansfeld, Friederike M., Giddam, Ashwini Kumar, Steyn, Frederik and Toth, Istvan (2017). New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency. International Journal of Pharmaceutics, 521 (1-2), 327-336. doi: 10.1016/j.ijpharm.2017.02.054

New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency

2017

Journal Article

Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties

Fagan, Vincent, Hussein, Waleed M., Su, Mei, Gidda, Ashwini K., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Simerska, Pavla (2017). Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties. ChemBioChem, 18 (6), 545-553. doi: 10.1002/cbic.201600639

Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties

2017

Journal Article

Intranasal delivery of nanoparticle-based vaccines

Marasini, Nirmal, Skwarczynski, Mariusz and Toth, Istvan (2017). Intranasal delivery of nanoparticle-based vaccines. Therapeutic Delivery, 8 (3), 151-167. doi: 10.4155/tde-2016-0068

Intranasal delivery of nanoparticle-based vaccines

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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