Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

Email: 

Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

141 - 160 of 683 works

2017

Journal Article

Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines

Hussein, Waleed M., Mukaida, Saori, Azmi, Fazren, Bartlett, Stacey, Olivier, Celine, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines. ACS Medicinal Chemistry Letters, 8 (2), 227-232. doi: 10.1021/acsmedchemlett.6b00453

Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines

2017

Journal Article

Poly-L-lysine-coated nanoparticles are ineffective in inducing mucosal immunity against group a streptococcus

Marasini, Nirmal, Giddam, Ashwini Kumar, Batzloff, Michael R. , Good, Michael F. , Skwarczynski, Mariusz and Toth, Istvan (2017). Poly-L-lysine-coated nanoparticles are ineffective in inducing mucosal immunity against group a streptococcus. Biochemical Compounds, 5 (1), 1.1-1.6. doi: 10.7243/2052-9341-5-1

Poly-L-lysine-coated nanoparticles are ineffective in inducing mucosal immunity against group a streptococcus

2017

Journal Article

Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus

Hussein, Waleed M., Xu, Jiaxin, Simerska, Pavla and Toth, Istvan (2017). Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus. Australian Journal of Chemistry, 70 (2), 184-190. doi: 10.1071/CH16501

Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus

2017

Journal Article

Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

Eskandari, Sharareh, Guerin, Thalia, Toth, Istvan and Stephenson, Rachel J. (2017). Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering. Advanced Drug Delivery Reviews, 110, 169-187. doi: 10.1016/j.addr.2016.06.013

Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

2017

Journal Article

The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus

Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus. Medicinal Chemistry, 13 (1), 22-27. doi: 10.2174/1573406412666160720093138

The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus

2017

Journal Article

An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity

Khatun, Farjana, Stephenson, Rachel J. and Toth, Istvan (2017). An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity. Chemistry - A European Journal, 23 (18), 4233-4254. doi: 10.1002/chem.201603599

An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity

2017

Journal Article

Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery.

Wan, Yu, Moyle, Peter M., Gn, Pei Z. and Toth, Istvan (2017). Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery.. Nanomedicine, 12 (4), 281-293. doi: 10.2217/nnm-2016-0354

Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery.

2017

Journal Article

Evaluation of lipopeptides as toll-like receptor 2 ligands

Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan and Simerska, P. (2017). Evaluation of lipopeptides as toll-like receptor 2 ligands. Current Drug Delivery, 14 (7), 935-943. doi: 10.2174/1567201813666160804114107

Evaluation of lipopeptides as toll-like receptor 2 ligands

2017

Book Chapter

Liposomes as a vaccine delivery system

Marasini, N., Ghaffar, K.A., Skwarczynski, M. and Toth, I. (2017). Liposomes as a vaccine delivery system. Micro and Nanotechnology in Vaccine Development. (pp. 221-239) edited by Mariusz Skwarczynski and Istvan Toth. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00012-9

Liposomes as a vaccine delivery system

2017

Book

Micro- and nanotechnology in vaccine development

Mariusz Skwarczynski and Istvan Toth eds. (2017). Micro- and nanotechnology in vaccine development. Amsterdam, Netherlands: Elsevier.

Micro- and nanotechnology in vaccine development

2017

Book Chapter

Micro- and Nanotechnology in Vaccine Development - Introduction

Skwarczynski, Mariusz and Toth, Istvan (2017). Micro- and Nanotechnology in Vaccine Development - Introduction. Micro- and Nanotechnology in Vaccine Development . (pp. XVII-XVIII) edited by Skwarczynski, M. and Toth, I.. Kidlington, Oxford, United Kingdom: Elsevier Science.

Micro- and Nanotechnology in Vaccine Development - Introduction

2017

Journal Article

Polyelectrolyte coated liposome delivery systems against Group A Streptococcus (GAS) infection

Toth, Istvan (2017). Polyelectrolyte coated liposome delivery systems against Group A Streptococcus (GAS) infection. Journal of Nanomedicine & Nanotechnology, 08 (04) doi: 10.4172/2157-7439-c1-048

Polyelectrolyte coated liposome delivery systems against Group A Streptococcus (GAS) infection

2016

Journal Article

Novel platform technology for modular mucosal vaccine that protects against streptococcus

Zaman, Mehfuz, Ozberk, Victoria, Langshaw, Emma L., McPhun, Virginia, Powell, Jessica L., Phillips, Zachary N., Ho, Mei Fong, Calcutt, Ainslie, Batzloff, Michael R., Toth, Istvan, Hill, Geoffrey R., Pandey, Manisha and Good, Michael F. (2016). Novel platform technology for modular mucosal vaccine that protects against streptococcus. Scientific Reports, 6 (1) 39274, 1-11. doi: 10.1038/srep39274

Novel platform technology for modular mucosal vaccine that protects against streptococcus

2016

Journal Article

Towards the development of synthetic antibiotics: designs inspired by natural antimicrobial peptides

Azmi, Fazren, Skwarczynski, Mariusz and Toth, Istvan (2016). Towards the development of synthetic antibiotics: designs inspired by natural antimicrobial peptides. Current Medicinal Chemistry, 23 (41), 4610-4624. doi: 10.2174/0929867323666160825162435

Towards the development of synthetic antibiotics: designs inspired by natural antimicrobial peptides

2016

Journal Article

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery

Marasini, Nirmal, Giddam, Ashwini K., Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Skwarczynski, Mariusz (2016). Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery. Nanomedicine, 11 (24), 3223-3235. doi: 10.2217/nnm-2016-0291

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery

2016

Journal Article

Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus

Marasini, Nirmal, Khalil, Zeinab G., Giddam, Ashwini K., Abdul Ghaffar, Khairunnisa, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. International Journal of Pharmaceutics, 513 (1-2), 410-420. doi: 10.1016/j.ijpharm.2016.09.057

Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus

2016

Journal Article

Investigation of Bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor

Begum, Anjuman Ara, Moyle, Peter M. and Toth, Istvan (2016). Investigation of Bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor. Bioorganic and Medicinal Chemistry, 24 (22), 5834-5841. doi: 10.1016/j.bmc.2016.09.039

Investigation of Bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor

2016

Journal Article

A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria

Giddam, Ashwini Kumar, Reiman, Jennifer M., Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2016). A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria. Acta Biomaterialia, 44, 295-303. doi: 10.1016/j.actbio.2016.08.020

A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria

2016

Journal Article

Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer

Hussein, Waleed M., Liu, Tzu-Yu, Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2016). Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer. Bioorganic and Medicinal Chemistry, 24 (18), 4372-4380. doi: 10.1016/j.bmc.2016.07.036

Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer

2016

Journal Article

Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides

Pignatello, Rosario, Simerska, Pavla, Leonardi, Antonio, Abdelrahim, Adel S., Petronio, Giulio Petronio, Fuochi, Virginia, Furneri, Pio Maria, Ruozi, Barbara and Toth, Istvan (2016). Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides. European Journal of Medicinal Chemistry, 120, 329-337. doi: 10.1016/j.ejmech.2016.04.074

Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au