Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

341 - 360 of 683 works

2008

Journal Article

N-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) Lipoamino Acids

Ross, Benjamin P., Falconer, Robert A. and Toth,, Istvan (2008). N-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) Lipoamino Acids. Molbank, 2008: M566 (2), M566. doi: 10.3390/M566

N-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) Lipoamino Acids

2008

Journal Article

Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection

Bulmer, Andrew C., Blanchfield, Joanne T., Toth, Istvan, Fassett, Robert G. and Coombes, Jeff S. (2008). Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection. Atherosclerosis, 199 (2), 390-396. doi: 10.1016/j.atherosclerosis.2007.11.022

Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection

2008

Journal Article

Effect of variation in the chain length and number in modulating the interaction of an immunogenic lipopeptide with biomembrane models

Sarpietro, Maria Grazia, Micieli, Dorotea, Pignatello, Rosario, Liang, Ming Tao, Toth, Istvan and Castelli, Francesco (2008). Effect of variation in the chain length and number in modulating the interaction of an immunogenic lipopeptide with biomembrane models. Thermochimica Acta, 471 (1-2), 14-19. doi: 10.1016/j.tca.2008.02.006

Effect of variation in the chain length and number in modulating the interaction of an immunogenic lipopeptide with biomembrane models

2008

Conference Publication

The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry

Coles, Daniel J., Yang, Shu, Minchin, Rodney F. and Toth, Istvan (2008). The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry. New York, N.Y.: John Wiley & Sons Ltd. doi: 10.1002/bip.21019

The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry

2008

Journal Article

Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues

Del Borgo, Mark P., Blanchfield, Joanne T. and Toth, Istvan (2008). Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorganic & Medicinal Chemistry, 16 (8), 4341-4346. doi: 10.1016/j.bmc.2008.02.074

Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues

2008

Journal Article

Optimized LC–MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as oral penetration enhancers

Violette, Aude, Faria Cortes, Diego A., Bergeon, Julie A., Falconer, Robert A. and Toth, I. (2008). Optimized LC–MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as oral penetration enhancers. International Journal of Pharmaceutics, 351 (1-2), 152-157. doi: 10.1016/j.ijpharm.2007.09.039

Optimized LC–MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as oral penetration enhancers

2008

Journal Article

A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix

Liang, M., Toth, I. and Davies, N. M. (2008). A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix. European Journal of Pharmaceutics and Biopharmaceutics, 68 (3), 840-845. doi: 10.1016/j.ejpb.2007.11.017

A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix

2008

Journal Article

Development of a liposaccharide-based delivery system and its application to the design of Group A streptococcal vaccines

Simerska, Pavla, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Moyle, Peter M., McGeary, Ross P., Batzloff, Michael R., Olive, Colleen, Good, Michael F. and Toth, Istvan (2008). Development of a liposaccharide-based delivery system and its application to the design of Group A streptococcal vaccines. Journal of Medicinal Chemistry, 51 (5), 1447-1452. doi: 10.1021/jm701410p

Development of a liposaccharide-based delivery system and its application to the design of Group A streptococcal vaccines

2008

Journal Article

Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates

Abdel-Aal, Abu-Baker M., Batzloff, Michael R., Fujita, Yoshio, Barozzi, Nadia, Faria, Andres, Simerska, Pavla, Moyle, Peter M., Good, Michael F. and Toth, Istvan (2008). Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates. Journal of Medicinal Chemistry, 51 (1), 167-172. doi: 10.1021/jm701091d

Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates

2008

Conference Publication

Improved resistance to serum oxidation in Gilberts syndrome: a mechanism for cardiovascular protection

Bulmer, A. C., Blanchfield, J. T., Toth, I., Fassett, R. G. and Coombes, J. S. (2008). Improved resistance to serum oxidation in Gilberts syndrome: a mechanism for cardiovascular protection. The 2008 meeting of the Society for Free Radical Research - Europe (SFRR-E, Berlin, Germany, 5th-9th July 2008. London: Gordon and Breach. doi: 10.1080/10715760802207914

Improved resistance to serum oxidation in Gilberts syndrome: a mechanism for cardiovascular protection

2008

Journal Article

Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides

Koda, Y., Del Borgo, M., Wessling, S., Lazarus, L. H., Okada, Y., Toth, I. and Blanchfield, J. T. (2008). Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. Bioorganic & Medicinal Chemistry, 16 (11), 6286-6296. doi: 10.1016/j.bmc.2008.04.020

Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides

2008

Journal Article

Discovery to Drugs: The Peptide Pipeline

Benson, H. and Toth, I. (2008). Discovery to Drugs: The Peptide Pipeline. Peptide Science, 90 (5), 588.

Discovery to Drugs: The Peptide Pipeline

2008

Journal Article

Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation

Bergeon, Julie A., Chan, Yiu-Ngok, Charles, Bruce G. and Toth, Istvan (2008). Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation. Peptide Science, 90 (5), 633-643. doi: 10.1002/bip.21003

Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation

2008

Journal Article

Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization

Liang, M., Davies, N. M. and Toth, I. (2008). Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization. International Journal of Pharmaceutics, 362 (1-2), 141-146. doi: 10.1016/j.ijpharm.2008.06.005

Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization

2008

Journal Article

In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin

Bulmer, A.C., Blanchfield, J.T., Coombes, J.S. and Toth, I. (2008). In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin. Bioorganic & Medicinal Chemistry, 16 (7), 3616-3625. doi: 10.1016/j.bmc.2008.02.008

In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin

2008

Conference Publication

Intestinal and intraperitoneal absorption and bioavailability of the antioxidants unconjugated bilirubin, biliverdin and bilirubin ditaurate in the rat

Bulmer, A. C., Coombes, J. S., Blanchfield, J. T., Toth, I., Fassett, R. G. and Taylor, S. M. (2008). Intestinal and intraperitoneal absorption and bioavailability of the antioxidants unconjugated bilirubin, biliverdin and bilirubin ditaurate in the rat. SFRR-E Berlin, Berlin, Germany, 5-9 July, 2008. London: Gordon and Breach. doi: 10.1080/10715760802207914

Intestinal and intraperitoneal absorption and bioavailability of the antioxidants unconjugated bilirubin, biliverdin and bilirubin ditaurate in the rat

2008

Journal Article

Self-adjuvanting lipopeptide vaccines

Moyle, P.M. and Toth, I. (2008). Self-adjuvanting lipopeptide vaccines. Current Medicinal Chemistry, 15 (5), 506-516. doi: 10.2174/092986708783503249

Self-adjuvanting lipopeptide vaccines

2008

Journal Article

In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue

Koda, Y., Liang, M., Blanchfield, J. T. and Toth, I. (2008). In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue. International Journal of Pharmaceutics, 356 (1-2), 37-43. doi: 10.1016/j.ijpharm.2007.12.036

In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue

2008

Conference Publication

Investigation toward multi-epitope vaccine candidates using native chemical ligation

Fujita, Yoshio, Moyle, Peter M., Hieu, Suzanne, Simerska, Pavla and Toth, Istvan (2008). Investigation toward multi-epitope vaccine candidates using native chemical ligation. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21002

Investigation toward multi-epitope vaccine candidates using native chemical ligation

2008

Conference Publication

Absorption and pharmacokinetics of bilirubin and biliverdin administration in the rat

Bulmer, A.C., Coombes, J.S., Blanchfield, J.T., Toth, I. and Taylor, S.M. (2008). Absorption and pharmacokinetics of bilirubin and biliverdin administration in the rat. Australian Health and Medical Research Congress, Brisbane, 16 - 21 November, 2008.

Absorption and pharmacokinetics of bilirubin and biliverdin administration in the rat

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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