
Overview
Background
Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.
Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.
Availability
- Professor Keith Chappell is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Keith is the co-leader of UQ's COVID-19 vaccine program, which produced one of the first vaccines to eneter clinical trials, in just 6 months after the pandemic was announced. In phase I clinical trials, UQ's COVID-19 vaccine was shown to be safe and produce a strong neutralising immune response, however the initial version was not progressed due to the induction of response that interfered with some HIV diagnostic tests. The outcome of UQ's COVID-19 vaccine program represents an important proof of principle finding for the molecular clamp technology and the team are now re-engineering the platform to aleviate the potential for diagnostic interferance.
Keith is the co-creator of the molecular clamp platform technology, which has potential to produce vaccines for many medically significant viral pathogens. This technology has received a total of over $30 million in investment from Australian competitive grant schemes, international funders and philanthropic organisations and Keith now leads a team of 12 researchers.
Keith also works on Koala retrovirus (KoRV), which is a signficant cause of disease amongst koala populations in QLD and NSW. This work has received research support from the ARC improved our understanding of KoRV genetic diversity, mode of transmission and the fundamental process of genome immunity which mitigates against disease.
Works
Search Professor Keith Chappell’s works on UQ eSpace
2005
Conference Publication
Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis
Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.
2004
Journal Article
Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease
Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200
Funding
Current funding
Supervision
Availability
- Professor Keith Chappell is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Silencing of fusion-gene expression in cancer with synthetic long-noncoding RNA therapies
Principal Advisor
-
Doctor Philosophy
Understanding vaccine-intrinsic factors which influence immunological memory and protection from disease
Principal Advisor
Other advisors: Dr Jake O'Donnell
-
Doctor Philosophy
Preclinical development and clinical testing of a Human T lymphotropic virus type 1 (HTLV-1)-specific vaccine
Associate Advisor
Other advisors: Dr Jake O'Donnell
Completed supervision
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2023
Doctor Philosophy
Understanding the koala retrovirus epidemic: genetic diversity, transmission and immunogenicity
Principal Advisor
Other advisors: Associate Professor Steve Johnston
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2019
Doctor Philosophy
Rational design of a recombinant subunit influenza vaccine
Principal Advisor
Other advisors: Professor Daniel Watterson
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2023
Doctor Philosophy
Structure-guided vaccine and therapeutic design for emerging viruses
Associate Advisor
Other advisors: Professor Daniel Watterson
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2021
Doctor Philosophy
Broad-Spectrum Vaccines & Therapeutics for Henipaviruses
Associate Advisor
Other advisors: Professor Daniel Watterson
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2020
Doctor Philosophy
The Filovirus glycoprotein as applied to rational vaccine design and diagnostics
Associate Advisor
Other advisors: Professor Daniel Watterson
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2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Daniel Watterson, Emeritus Professor Istvan Toth, Associate Professor Mariusz Skwarczynski
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2018
Doctor Philosophy
Structural and functional studies of the respiratory syncytial virus F protein
Associate Advisor
Other advisors: Professor Daniel Watterson
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2017
Doctor Philosophy
Dengue virus NS2B-NS3protease as a target for inhibitor-drugs
Associate Advisor
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2017
Doctor Philosophy
Viral/bacterial respiratory tract co-infections in children
Associate Advisor
Other advisors: Professor Phil Hugenholtz
Media
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