
Overview
Background
Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.
Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.
Availability
- Professor Keith Chappell is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Keith is the co-leader of UQ's COVID-19 vaccine program, which produced one of the first vaccines to eneter clinical trials, in just 6 months after the pandemic was announced. In phase I clinical trials, UQ's COVID-19 vaccine was shown to be safe and produce a strong neutralising immune response, however the initial version was not progressed due to the induction of response that interfered with some HIV diagnostic tests. The outcome of UQ's COVID-19 vaccine program represents an important proof of principle finding for the molecular clamp technology and the team are now re-engineering the platform to aleviate the potential for diagnostic interferance.
Keith is the co-creator of the molecular clamp platform technology, which has potential to produce vaccines for many medically significant viral pathogens. This technology has received a total of over $30 million in investment from Australian competitive grant schemes, international funders and philanthropic organisations and Keith now leads a team of 12 researchers.
Keith also works on Koala retrovirus (KoRV), which is a signficant cause of disease amongst koala populations in QLD and NSW. This work has received research support from the ARC improved our understanding of KoRV genetic diversity, mode of transmission and the fundamental process of genome immunity which mitigates against disease.
Works
Search Professor Keith Chappell’s works on UQ eSpace
2019
Journal Article
Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections
Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2019). Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections. Microbiology, 166 (1) 000870, 63-72. doi: 10.1099/mic.0.000870
2019
Journal Article
The piRNA response to retroviral invasion of the koala genome
Yu, Tianxiong, Koppetsch, Birgit S, Pagliarani, Sara, Johnston, Stephen, Silverstein, Noah J, Luban, Jeremy, Chappell, Keith, Weng, Zhiping and Theurkauf, William E (2019). The piRNA response to retroviral invasion of the koala genome. Cell, 179 (3), 632-643.e12. doi: 10.1016/j.cell.2019.09.002
2019
Journal Article
An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Do, Lien Anh Ha, Tse, Reuben, Nathanielsz, Jordan, Anderson, Jeremy, Ong, Darren Suryawijaya, Chappell, Keith, Mulholland, Kim and Licciardi, Paul V. (2019). An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay. Journal of Visualized Experiments : JoVE, 2019 (143) e59025. doi: 10.3791/59025
2018
Journal Article
Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children
Brealey, Jaelle C., Chappell, Keith J., Galbraith, Sally, Fantino, Emmanuelle, Gaydon, Jane, Tozer, Sarah, Young, Paul R., Holt, Patrick G. and Sly, Peter D. (2018). Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children. Respirology, 23 (2), 220-227. doi: 10.1111/resp.13179
2018
Journal Article
The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion
Bermingham, Imogen M., Chappell, Keith J., Watterson, Daniel and Young, Paul R. (2018). The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion. Journal of Virology, 92 (4) e01323-17, 1-14. doi: 10.1128/JVI.01323-17
2018
Journal Article
Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection
Chan, Kok Fei, Carolan, Louise A., Druce, Julian, Chappell, Keith, Watterson, Daniel, Young, Paul, Korenkov, Daniil, Subbarao, Kanta, Barr, Ian G., Laurie, Karen L. and Reading, Patrick C. (2018). Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection. Journal of Virology, 92 (4) e01322-17, 1-17. doi: 10.1128/JVI.01322-17
2017
Journal Article
Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein
Jaberolansar, Noushin, Chappell, Keith J., Watterson, Daniel, Bermingham, Imogen M., Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2017). Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Scientific Reports, 7 (1) 11130, 11130. doi: 10.1038/s41598-017-10415-w
2017
Journal Article
Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG
Pyankov, Oleg V., Setoh, Yin Xiang, Bodnev, Sergey A., Edmonds, Judith H., Pyankova, Olga G., Pyankov, Stepan A., Pali, Gabor, Belford, Shane, Lu, Louis, La, Mylinh, Lovrecz, George, Volchkova, Valentina A., Chappell, Keith J., Watterson, Daniel, Marsh, Glenn, Young, Paul R., Agafonov, Alexander A., Farmer, Jillann F., Volchkov, Victor E., Suhrbier, Andreas and Khromykh, Alexander A. (2017). Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG. Scientific Reports, 7 (1) 41537, 41537. doi: 10.1038/srep41537
2017
Journal Article
Fighting Ebola: a window for vaccine re-evaluation?
Chappell, Keith J. and Watterson, Daniel (2017). Fighting Ebola: a window for vaccine re-evaluation?. PLoS Pathogens, 13 (1) e1006037, e1006037. doi: 10.1371/journal.ppat.1006037
2016
Journal Article
Product release is rate-limiting for catalytic processing by the Dengue virus protease
Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539
2016
Journal Article
Phylogenetic diversity of koala retrovirus within a wild koala population
Chappell, K. J., Brealey, J. C., Amarilla, A. A., Watterson, D., Hulse, L., Palmieri, C., Johnston, S. D., Holmes, E. C., Meers, J. and Young, P. (2016). Phylogenetic diversity of koala retrovirus within a wild koala population. Journal of Virology, 91 (3) e01820-16, 363-374. doi: 10.1128/JVI.01820-16
2016
Journal Article
Proteoform-specific insights into cellular proteome regulation
Norris, Emma L., Headlam, Madeleine J., Dave, Keyur A., Smith, David D., Bukreyev, Alexander, Singh, Toshna, Jayakody, Buddhika A., Chappell, Keith J., Collins, Peter L. and Gorman, Jeffrey J. (2016). Proteoform-specific insights into cellular proteome regulation. Molecular and Cellular Proteomics, 15 (10), 3297-3320. doi: 10.1074/mcp.O116.058438
2016
Journal Article
Viral pathogen vaccines
Young, Paul, Chappell, Keith and Watterson, Dan (2016). Viral pathogen vaccines. Australasian Biotechnology, 26 (3), 35-35.
2016
Journal Article
Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages
Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023
2016
Journal Article
A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance
Watterson, Daniel, Robinson, Jodie, Chappell, Keith J., Butler, Mark S., Edwards, David J., Fry, Scott R., Bermingham, Imogen M., Cooper, Matthew A. and Young, Paul R. (2016). A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance. Scientific Reports, 6 (22791) 22791, 1-9. doi: 10.1038/srep22791
2015
Journal Article
Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.
Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022
2015
Journal Article
Viral bacterial co-infection of the respiratory tract during early childhood
Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2015). Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiology Letters, 362 (10) fnv062. doi: 10.1093/femsle/fnv062
2014
Book Chapter
The nonstructural proteins of dengue virus
Chappell, Keith J. and Young, Paul R. (2014). The nonstructural proteins of dengue virus. Dengue and Dengue Hemorrhagic Fever: Second Edition. (pp. 377-405) edited by D. J. Gubler, Eng Eong Ooi, Subhash Vasudevan and Jeremy Farrar. Oxfordshire, United Kingdom: CABI International. doi: 10.1079/9781845939649.0377
2013
Conference Publication
Novel inhibitors of DENV NS2B/NS3pro protease
Chow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC.
2013
Journal Article
Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children
Chappell, K.J., Brealey, J.C., Mackay, I.M., Bletchly, C., Hugenholtz, P., Sloots, T.P., Sly, P.D. and Young, P.R. (2013). Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children. Journal of Medical Microbiology & Diagnosis, S (1), 1-9. doi: 10.4172/2161-0703.S1-005
Funding
Current funding
Supervision
Availability
- Professor Keith Chappell is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Silencing of fusion-gene expression in cancer with synthetic long-noncoding RNA therapies
Principal Advisor
-
Doctor Philosophy
Understanding vaccine-intrinsic factors which influence immunological memory and protection from disease
Principal Advisor
Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar
-
Doctor Philosophy
Preclinical development and clinical testing of a Human T lymphotropic virus type 1 (HTLV-1)-specific vaccine
Associate Advisor
Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar
Completed supervision
-
2023
Doctor Philosophy
Understanding the koala retrovirus epidemic: genetic diversity, transmission and immunogenicity
Principal Advisor
Other advisors: Associate Professor Steve Johnston
-
2019
Doctor Philosophy
Rational design of a recombinant subunit influenza vaccine
Principal Advisor
Other advisors: Professor Daniel Watterson
-
2023
Doctor Philosophy
Structure-guided vaccine and therapeutic design for emerging viruses
Associate Advisor
Other advisors: Professor Daniel Watterson
-
2021
Doctor Philosophy
Broad-Spectrum Vaccines & Therapeutics for Henipaviruses
Associate Advisor
Other advisors: Professor Daniel Watterson
-
2020
Doctor Philosophy
The Filovirus glycoprotein as applied to rational vaccine design and diagnostics
Associate Advisor
Other advisors: Professor Daniel Watterson
-
2018
Doctor Philosophy
Structural and functional studies of the respiratory syncytial virus F protein
Associate Advisor
Other advisors: Professor Daniel Watterson
-
2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Daniel Watterson, Emeritus Professor Istvan Toth, Associate Professor Mariusz Skwarczynski
-
2017
Doctor Philosophy
Dengue virus NS2B-NS3protease as a target for inhibitor-drugs
Associate Advisor
-
2017
Doctor Philosophy
Viral/bacterial respiratory tract co-infections in children
Associate Advisor
Other advisors: Professor Phil Hugenholtz
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