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Professor Keith Chappell
Professor

Keith Chappell

Email: 
Phone: 
+61 7 344 32597

Overview

Background

Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.

Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.

Availability

Professor Keith Chappell is:
Available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research impacts

Keith is the co-leader of UQ's COVID-19 vaccine program, which produced one of the first vaccines to eneter clinical trials, in just 6 months after the pandemic was announced. In phase I clinical trials, UQ's COVID-19 vaccine was shown to be safe and produce a strong neutralising immune response, however the initial version was not progressed due to the induction of response that interfered with some HIV diagnostic tests. The outcome of UQ's COVID-19 vaccine program represents an important proof of principle finding for the molecular clamp technology and the team are now re-engineering the platform to aleviate the potential for diagnostic interferance.

Keith is the co-creator of the molecular clamp platform technology, which has potential to produce vaccines for many medically significant viral pathogens. This technology has received a total of over $30 million in investment from Australian competitive grant schemes, international funders and philanthropic organisations and Keith now leads a team of 12 researchers.

Keith also works on Koala retrovirus (KoRV), which is a signficant cause of disease amongst koala populations in QLD and NSW. This work has received research support from the ARC improved our understanding of KoRV genetic diversity, mode of transmission and the fundamental process of genome immunity which mitigates against disease.

Works

Search Professor Keith Chappell’s works on UQ eSpace

79 works between 2004 and 2025

41 - 60 of 79 works

2019

Journal Article

Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections

Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2019). Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections. Microbiology, 166 (1) 000870, 63-72. doi: 10.1099/mic.0.000870

Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections

2019

Journal Article

The piRNA response to retroviral invasion of the koala genome

Yu, Tianxiong, Koppetsch, Birgit S, Pagliarani, Sara, Johnston, Stephen, Silverstein, Noah J, Luban, Jeremy, Chappell, Keith, Weng, Zhiping and Theurkauf, William E (2019). The piRNA response to retroviral invasion of the koala genome. Cell, 179 (3), 632-643.e12. doi: 10.1016/j.cell.2019.09.002

The piRNA response to retroviral invasion of the koala genome

2019

Journal Article

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

Do, Lien Anh Ha, Tse, Reuben, Nathanielsz, Jordan, Anderson, Jeremy, Ong, Darren Suryawijaya, Chappell, Keith, Mulholland, Kim and Licciardi, Paul V. (2019). An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay. Journal of Visualized Experiments : JoVE, 2019 (143) e59025. doi: 10.3791/59025

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

2018

Journal Article

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

Brealey, Jaelle C., Chappell, Keith J., Galbraith, Sally, Fantino, Emmanuelle, Gaydon, Jane, Tozer, Sarah, Young, Paul R., Holt, Patrick G. and Sly, Peter D. (2018). Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children. Respirology, 23 (2), 220-227. doi: 10.1111/resp.13179

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

2018

Journal Article

The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion

Bermingham, Imogen M., Chappell, Keith J., Watterson, Daniel and Young, Paul R. (2018). The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion. Journal of Virology, 92 (4) e01323-17, 1-14. doi: 10.1128/JVI.01323-17

The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion

2018

Journal Article

Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection

Chan, Kok Fei, Carolan, Louise A., Druce, Julian, Chappell, Keith, Watterson, Daniel, Young, Paul, Korenkov, Daniil, Subbarao, Kanta, Barr, Ian G., Laurie, Karen L. and Reading, Patrick C. (2018). Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection. Journal of Virology, 92 (4) e01322-17, 1-17. doi: 10.1128/JVI.01322-17

Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection

2017

Journal Article

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

Jaberolansar, Noushin, Chappell, Keith J., Watterson, Daniel, Bermingham, Imogen M., Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2017). Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Scientific Reports, 7 (1) 11130, 11130. doi: 10.1038/s41598-017-10415-w

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

2017

Journal Article

Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG

Pyankov, Oleg V., Setoh, Yin Xiang, Bodnev, Sergey A., Edmonds, Judith H., Pyankova, Olga G., Pyankov, Stepan A., Pali, Gabor, Belford, Shane, Lu, Louis, La, Mylinh, Lovrecz, George, Volchkova, Valentina A., Chappell, Keith J., Watterson, Daniel, Marsh, Glenn, Young, Paul R., Agafonov, Alexander A., Farmer, Jillann F., Volchkov, Victor E., Suhrbier, Andreas and Khromykh, Alexander A. (2017). Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG. Scientific Reports, 7 (1) 41537, 41537. doi: 10.1038/srep41537

Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG

2017

Journal Article

Fighting Ebola: a window for vaccine re-evaluation?

Chappell, Keith J. and Watterson, Daniel (2017). Fighting Ebola: a window for vaccine re-evaluation?. PLoS Pathogens, 13 (1) e1006037, e1006037. doi: 10.1371/journal.ppat.1006037

Fighting Ebola: a window for vaccine re-evaluation?

2016

Journal Article

Product release is rate-limiting for catalytic processing by the Dengue virus protease

Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539

Product release is rate-limiting for catalytic processing by the Dengue virus protease

2016

Journal Article

Phylogenetic diversity of koala retrovirus within a wild koala population

Chappell, K. J., Brealey, J. C., Amarilla, A. A., Watterson, D., Hulse, L., Palmieri, C., Johnston, S. D., Holmes, E. C., Meers, J. and Young, P. (2016). Phylogenetic diversity of koala retrovirus within a wild koala population. Journal of Virology, 91 (3) e01820-16, 363-374. doi: 10.1128/JVI.01820-16

Phylogenetic diversity of koala retrovirus within a wild koala population

2016

Journal Article

Proteoform-specific insights into cellular proteome regulation

Norris, Emma L., Headlam, Madeleine J., Dave, Keyur A., Smith, David D., Bukreyev, Alexander, Singh, Toshna, Jayakody, Buddhika A., Chappell, Keith J., Collins, Peter L. and Gorman, Jeffrey J. (2016). Proteoform-specific insights into cellular proteome regulation. Molecular and Cellular Proteomics, 15 (10), 3297-3320. doi: 10.1074/mcp.O116.058438

Proteoform-specific insights into cellular proteome regulation

2016

Journal Article

Viral pathogen vaccines

Young, Paul, Chappell, Keith and Watterson, Dan (2016). Viral pathogen vaccines. Australasian Biotechnology, 26 (3), 35-35.

Viral pathogen vaccines

2016

Journal Article

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

2016

Journal Article

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

Watterson, Daniel, Robinson, Jodie, Chappell, Keith J., Butler, Mark S., Edwards, David J., Fry, Scott R., Bermingham, Imogen M., Cooper, Matthew A. and Young, Paul R. (2016). A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance. Scientific Reports, 6 (22791) 22791, 1-9. doi: 10.1038/srep22791

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

2015

Journal Article

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

2015

Journal Article

Viral bacterial co-infection of the respiratory tract during early childhood

Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2015). Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiology Letters, 362 (10) fnv062. doi: 10.1093/femsle/fnv062

Viral bacterial co-infection of the respiratory tract during early childhood

2014

Book Chapter

The nonstructural proteins of dengue virus

Chappell, Keith J. and Young, Paul R. (2014). The nonstructural proteins of dengue virus. Dengue and Dengue Hemorrhagic Fever: Second Edition. (pp. 377-405) edited by D. J. Gubler, Eng Eong Ooi, Subhash Vasudevan and Jeremy Farrar. Oxfordshire, United Kingdom: CABI International. doi: 10.1079/9781845939649.0377

The nonstructural proteins of dengue virus

2013

Conference Publication

Novel inhibitors of DENV NS2B/NS3pro protease

Chow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC.

Novel inhibitors of DENV NS2B/NS3pro protease

2013

Journal Article

Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children

Chappell, K.J., Brealey, J.C., Mackay, I.M., Bletchly, C., Hugenholtz, P., Sloots, T.P., Sly, P.D. and Young, P.R. (2013). Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children. Journal of Medical Microbiology & Diagnosis, S (1), 1-9. doi: 10.4172/2161-0703.S1-005

Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children

Funding

Current funding

  • 2024 - 2025
    Determination of koala retrovirus subtypes and load for Koala Conservation Australia's breeding program
    Koala Conservation Australia Limited
    Open grant
  • 2024 - 2027
    Hyperactive endogenous retroviruses and their impact on the koala genome
    ARC Discovery Projects
    Open grant
  • 2023 - 2025
    A reengineered Molecular Clamp platform to safeguard Australia against novel viral threats
    Golden Casket Lottery Corporation Ltd
    Open grant
  • 2020 - 2028
    COVID-19 Vaccine Research (CEPI)
    The a2 Milk Company (Australia) Pty Ltd
    Open grant

Past funding

  • 2024
    Koala retrovirus subtyping for Symbio Wildlife Park
    J.M.R PTY Limited
    Open grant
  • 2024
    Determination of koala retrovirus subtypes and load at potential koala breeding program release sites
    Taronga Conservation Society Australia trading as Taronga Zoo
    Open grant
  • 2022 - 2024
    Do environmental stressors increase retrovirus activity and exacerbate disease in koalas?
    New South Wales Department of Planning and Environment
    Open grant
  • 2021 - 2022
    Molecular Clamp Stabilised HTLV-1 Envelope Glycoprotein for Vaccination and Immunotherapy
    Australian Centre for HIV and Hepatitis Virology Research (ACH2)
    Open grant
  • 2020 - 2024
    Rapid Acceleration of the UQ COVID-19 vaccine in Conjunction Program
    Queensland Department of State Development, Tourism and Innovation
    Open grant
  • 2020 - 2022
    Molecular Clamp Stabilized Spike Vaccine for Rapid Response
    NHMRC MRFF EPCDR - Novel Coronavirus Vaccine Development
    Open grant
  • 2020 - 2023
    Rapid Acceleration of the UQ COVID-19 Vaccine Program
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2019 - 2021
    Clamp stabilized vaccines to provide broad spectrum protection against influenza
    NHMRC Development Grant
    Open grant
  • 2018 - 2022
    Koala retrovirus epidemic: genetic diversity, genome invasion and disease
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    Virus vaccines that ensure preparedness against future public health emergencies
    NHMRC Project Grant
    Open grant

Supervision

Availability

Professor Keith Chappell is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Silencing of fusion-gene expression in cancer with synthetic long-noncoding RNA therapies

    Principal Advisor

  • Doctor Philosophy

    Understanding vaccine-intrinsic factors which influence immunological memory and protection from disease

    Principal Advisor

    Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar

  • Doctor Philosophy

    Preclinical development and clinical testing of a Human T lymphotropic virus type 1 (HTLV-1)-specific vaccine

    Associate Advisor

    Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar

Completed supervision

Media

Enquiries

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