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2023 Journal Article Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasisLim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558 |
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2023 Journal Article An immunomodulating peptide with potential to suppress tumour growth and autoimmunityAgrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide with potential to suppress tumour growth and autoimmunity. Scientific Reports, 13 (1) 19741, 19741. doi: 10.1038/s41598-023-47229-y |
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2023 Journal Article Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkersBalaji, Arunpandian, Bell, Craig A., Houston, Zachary H., Bridle, Kim R., Genz, Berit, Fletcher, Nicholas L., Ramm, Grant A. and Thurecht, Kristofer J. (2023). Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers. Biomaterials, 302 122318, 1-18. doi: 10.1016/j.biomaterials.2023.122318 |
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2023 Journal Article Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporationHuda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036 |
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2023 Journal Article An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damageAgrez, Michael, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Mason, Rebecca Sara, Chandler, Christopher, Piva, Terrence J., Thurecht, Kristofer, Fletcher, Nicholas, Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew, Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Scientific Reports, 13 (1) 11702, 1-19. doi: 10.1038/s41598-023-38890-4 |
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2023 Journal Article RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivoArdana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085 |
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2023 Journal Article Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemiaMoles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262 |
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2023 Journal Article Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranosticChu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138 |
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2023 Journal Article Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastomaJanjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J. and Popat, Amirali (2023). Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. Journal of Controlled Release, 357, 161-174. doi: 10.1016/j.jconrel.2023.03.040 |
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2023 Journal Article Combination of chemotherapy and mild hyperthermia using targeted nanoparticles: a potential treatment modality for breast cancerKaur, Ishdeep, Tieu, Terence, Deepagan, Veerasikku G., Ali, Muhammad A., Alsunaydih, Fahad, Rudd, David, Moghaddam, Maliheh A., Bourgeois, Laure, Adams, Timothy E., Thurecht, Kristofer J., Yuce, Mehmet, Cifuentes-Rius, Anna and Voelcker, Nicolas H. (2023). Combination of chemotherapy and mild hyperthermia using targeted nanoparticles: a potential treatment modality for breast cancer. Pharmaceutics, 15 (5) 1389, 1-23. doi: 10.3390/pharmaceutics15051389 |
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2023 Journal Article Homochiral poly(2‐oxazoline)‐based membrane for efficient enantioselective separationWang, Fanmengjing, Pizzi, David, Lu, Yizhihao, He, Kaiqiang, Thurecht, Kristofer J., Hill, Matthew R., Marriott, Philip, Holl, Mark M. Banaszak, Kempe, Kristian and Wang, Huanting (2023). Homochiral poly(2‐oxazoline)‐based membrane for efficient enantioselective separation. Angewandte Chemie International Edition, 62 (8) e202212139, 1-6. doi: 10.1002/anie.202212139 |
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2023 Journal Article Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in GlioblastomaGhosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760 |
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2023 Journal Article Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platformArno, Maria C., Simpson, Joshua D., Blackman, Lewis D., Brannigan, Ruairí P., Thurecht, Kristofer J. and Dove, Andrew P. (2023). Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform. Biomaterials Science, 11 (3), 908-915. doi: 10.1039/d2bm01626e |
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2022 Journal Article Utilizing PET and MALDI imaging for discovery of a targeted probe for brain endocannabinoid α/β-hydrolase domain 6 (ABHD6)Mardon, Karine, Patel, Jayendra Z., Savinainen, Juha R., Stimson, Damion H. R., Oyagawa, Caitlin R. M., Grimsey, Natasha L., Migotto, Mary-anne, Njiru, Grace F. M., Hamilton, Brett R., Cowin, Gary, Yli-Kauhaluoma, Jari, Vanduffel, Wim, Blakey, Idriss, Bhalla, Rajiv, Cawthorne, Christopher, Celen, Sofie, Bormans, Guy, Thurecht, Kristofer J and Ahamed, Muneer (2022). Utilizing PET and MALDI imaging for discovery of a targeted probe for brain endocannabinoid α/β-hydrolase domain 6 (ABHD6). Journal of Medicinal Chemistry, 66 (1), 538-552. doi: 10.1021/acs.jmedchem.2c01485 |
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2022 Journal Article Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)sPizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2022). Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s. Biomacromolecules, 24 (1), 246-257. doi: 10.1021/acs.biomac.2c01105 |
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2022 Journal Article Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterialsMills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J. and Fletcher, Nicholas L. (2022). Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials. Molecular Pharmaceutics, 19 (11), 4080-4097. doi: 10.1021/acs.molpharmaceut.2c00528 |
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2022 Journal Article Modeling brain metastasis by internal carotid artery injection of cancer cellsLim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216 |
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2022 Journal Article Protected amine-functional initiators for the synthesis of α-amine homo- and heterotelechelic poly(2-ethyl-2-oxazoline)sMazrad, Zihnil A. I., Lai, May, Davis, Thomas P., Nicolazzo, Joseph A., Thurecht, Kristofer J., Leiske, Meike N. and Kempe, Kristian (2022). Protected amine-functional initiators for the synthesis of α-amine homo- and heterotelechelic poly(2-ethyl-2-oxazoline)s. Polymer Chemistry, 13 (30), 4436-4445. doi: 10.1039/d2py00649a |
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2022 Journal Article A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responsesAgrez, Michael, Rzepecka, Justyna, Turner, Darryl, Knox, Gavin, Chandler, Christopher, Howard, Christopher B., Fletcher, Nicholas, Thurecht, Kristofer, Parker, Stephen, Gooding, Hayley and Gallagher, Laura (2022). A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses. Scientific Reports, 12 (1) 11185, 11185. doi: 10.1038/s41598-022-15455-5 |
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2022 Journal Article Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted deliveryGao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h |
