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2021 Journal Article Small cyclic sodium channel inhibitorsPeigneur, Steve, da Costa Oliveira, Cristina, de Sousa Fonseca, Flávia Cristina, McMahon, Kirsten L., Mueller, Alexander, Cheneval, Olivier, Cristina Nogueira Freitas, Ana, Starobova, Hana, Dimitri Gama Duarte, Igor, Craik, David J., Vetter, Irina, de Lima, Maria Elena, Schroeder, Christina I. and Tytgat, Jan (2021). Small cyclic sodium channel inhibitors. Biochemical Pharmacology, 183 114291, 114291. doi: 10.1016/j.bcp.2020.114291 |
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2020 Journal Article Pharmacology and therapeutic potential of venom peptidesRobinson, Samuel D. and Vetter, Irina (2020). Pharmacology and therapeutic potential of venom peptides. Biochemical Pharmacology, 181 114207, 114207. doi: 10.1016/j.bcp.2020.114207 |
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2020 Journal Article Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitorMcMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391 |
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2020 Journal Article Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predatorsHerzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117 |
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2020 Journal Article Neurotoxic peptides from the venom of the giant Australian stinging treeGilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828 |
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2020 Journal Article The NLRP3 inflammasome: role and therapeutic potential in pain treatmentStarobova, Hana, Nadar, Evelyn Israel and Vetter, Irina (2020). The NLRP3 inflammasome: role and therapeutic potential in pain treatment. Frontiers in Physiology, 11 1016, 1016. doi: 10.3389/fphys.2020.01016 |
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2020 Journal Article Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitorSharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148 |
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2020 Journal Article It takes two: dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosulaNixon, Samantha A., Dekan, Zoltan, Robinson, Samuel D., Guo, Shaodong, Vetter, Irina, Kotze, Andrew C., Alewood, Paul F., King, Glenn F. and Herzig, Volker (2020). It takes two: dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula. Biomedicines, 8 (7) 185, 1-13. doi: 10.3390/biomedicines8070185 |
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2020 Journal Article Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probeIsrael, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe. Biomedicines, 8 (6) 155, 155. doi: 10.3390/biomedicines8060155 |
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2020 Journal Article Pharmacological activity and NMR solution structure of the leech peptide HSTX-IMcMahon, Kirsten L., Tay, Bryan, Deuis, Jennifer R., Tanaka, Brian S., Peigneur, Steve, Jin, Ai-Hua, Tytgat, Jan, Waxman, Stephen G., Dib-Hajj, Sulayman D., Vetter, Irina and Schroeder, Christina I. (2020). Pharmacological activity and NMR solution structure of the leech peptide HSTX-I. Biochemical Pharmacology, 181 114082, 114082. doi: 10.1016/j.bcp.2020.114082 |
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2020 Journal Article An integrated proteomic and transcriptomic analysis reveals the venom complexity of the bullet ant Paraponera clavataAili, Samira R., Touchard, Axel, Hayward, Regan, Robinson, Samuel D., Pineda, Sandy S., Lalagüe, Hadrien, Mrinalini, Vetter, Irina, Undheim, Eivind A. B., Kini, R. Manjunatha, Escoubas, Pierre, Padula, Matthew P., Myers, Garry S. A. and Nicholson, Graham M. (2020). An integrated proteomic and transcriptomic analysis reveals the venom complexity of the bullet ant Paraponera clavata. Toxins, 12 (5) 324, 1-30. doi: 10.3390/toxins12050324 |
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2020 Journal Article Characterisation of a novel a-superfamily conotoxinWilson, David T., Bansal, Paramjit S., Carter, David A., Vetter, Irina, Nicke, Annette, Dutertre, Sébastien and Daly, Norelle L. (2020). Characterisation of a novel a-superfamily conotoxin. Biomedicines, 8 (5) 128, 128. doi: 10.3390/BIOMEDICINES8050128 |
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2020 Journal Article Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281 |
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2020 Journal Article NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet syndromeWeuring, Wout J., Singh, Sakshi, Volkers, Linda, Rook, Martin B., Van't Slot, Ruben H., Bosma, Marjolein, Inserra, Marco, Vetter, Irina, Verhoeven-Duif, Nanda M., Braun, Kees P. J., Rivara, Mirko and Koeleman, Bobby P. C. (2020). NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet syndrome. PLoS ONE, 15 (3) e0219106, e0219106. doi: 10.1371/journal.pone.0219106 |
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2020 Journal Article Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactionsMueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002 |
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2020 Journal Article Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037 |
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2020 Journal Article A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functionsAzimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081 |
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2020 Journal Article Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discoveryHerzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina and King, Glenn F. (2020). Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery. Biochemical Pharmacology, 181 114096, 114096. doi: 10.1016/j.bcp.2020.114096 |
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2020 Journal Article Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080 |
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2019 Journal Article Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibitionTran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744 |
