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2024 Journal Article The ‘dispanins’ and related proteins in physiology and neurological diseaseDeuis, Jennifer R., Klasfauseweh, Tabea, Walker, Lucinda and Vetter, Irina (2024). The ‘dispanins’ and related proteins in physiology and neurological disease. Trends in Neurosciences, 47 (8), 622-634. doi: 10.1016/j.tins.2024.06.004 |
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2024 Conference Publication Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model dataVan Cutsem, Eric, Ochsenreither, Sebastian, Collignon, Joelle, Eefsen, Rikke Løvendahl, Ivanauskas, Audrius, Shatunova, Svetlana, Vetter, Irina, Gyllenbäck, Elin Jaensson, Skoog, Petter, Losic, Nedjad, Tersago, Dominique and Starobova, Hana (2024). Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model data. 2024 ASCO Annual Meeting, Chicago, IL United States, 31 May - 4 June 2024. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2024.42.16_suppl.4148 |
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2024 Journal Article How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessmentKalia, Anil Kumar, Roesseler, Corinna, Granja-Vazquez, Rafael, Ahmad, Ayesha, Pancrazio, Joseph J., Neureiter, Anika, Zhang, Mei, Sauter, Daniel, Vetter, Irina, Andersson, Asa, Dussor, Gregory, Price, Theodore J., Kolber, Benedict J., Truong, Vincent, Walsh, Patrick and Lampert, Angelika (2024). How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment. Stem Cell Research & Therapy, 15 (1) ARTN 99. doi: 10.1186/s13287-024-03696-2 |
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2024 Journal Article Structural analysis of a U-superfamily conotoxin containing a mini-granulin fold: Insights into key features that distinguish between the ICK and granulin foldsRaffaelli, Tiziano, Wilson, David T., Dutertre, Sebastien, Giribaldi, Julien, Vetter, Irina, Robinson, Samuel D., Thapa, Ashvriya, Widi, Antin, Loukas, Alex and Daly, Norelle L. (2024). Structural analysis of a U-superfamily conotoxin containing a mini-granulin fold: Insights into key features that distinguish between the ICK and granulin folds. Journal of Biological Chemistry, 300 (4) 107203, 107203. doi: 10.1016/j.jbc.2024.107203 |
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2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055 |
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2024 Journal Article Voltage-gated sodium channel inhibition by µ-conotoxinsMcMahon, Kirsten L., Vetter, Irina and Schroeder, Christina I. (2024). Voltage-gated sodium channel inhibition by µ-conotoxins. Toxins, 16 (1) 55. doi: 10.3390/toxins16010055 |
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2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621 |
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2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621 |
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2024 Journal Article Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152 |
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2024 Journal Article Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester antsRobinson, Samuel D., Deuis, Jennifer R., Niu, Pancong, Touchard, Axel, Mueller, Alexander, Schendel, Vanessa, Brinkwirth, Nina, King, Glenn F., Vetter, Irina and Schmidt, Justin O. (2024). Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. Journal of Biological Chemistry, 300 (1) 105577, 1-15. doi: 10.1016/j.jbc.2023.105577 |
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2023 Journal Article Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activityXie, Fengjuan, Lin, Yingying, Andersson, Åsa, Vetter, Irina, Zhao, Liang and Wan, JingJing (2023). Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity. Chemical Communications, 59 (93), 13855-13858. doi: 10.1039/d3cc03801g |
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2023 Journal Article Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channelsPérez, Rebeca, Figueredo, Claudia, Burgos, Viviana, Cabrera-Pardo, Jaime R., Schmidt, Bernd, Heydenreich, Matthias, Koch, Andreas, Deuis, Jennifer R., Vetter, Irina and Paz, Cristian (2023). Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels. International Journal of Molecular Sciences, 24 (21) 15504, 1-10. doi: 10.3390/ijms242115504 |
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2023 Journal Article GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanismsRagnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776 |
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2023 Journal Article Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and AfonsoconusMcMahon, Kirsten L., O’Brien, Henrik, Schroeder, Christina I., Deuis, Jennifer R., Venkatachalam, Dhananjeyan, Huang, Di, Green, Brad R., Bandyopadhyay, Pradip K., Li, Qing, Yandell, Mark, Safavi-Hemami, Helena, Olivera, Baldomero M., Vetter, Irina and Robinson, Samuel D. (2023). Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus. Cellular and Molecular Life Sciences, 80 (10) 287, 287. doi: 10.1007/s00018-023-04935-0 |
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2023 Journal Article Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venomGalante, Priscilla, Campos, Gabriel A. A., Moser, Jacqueline C. G., Martins, Danubia B., Dos Santos Cabrera, Marcia P., Rangel, Marisa, Coelho, Luiza C., Simon, Karina S., Amado, Veronica M., de A. I. Muller, Jessica, Koehbach, Johannes, Lohman, Rink-Jan, Cabot, Peter J., Vetter, Irina, Craik, David J., Toffoli-Kadri, Monica C., Monge-Fuentes, Victoria, Goulart, Jair T., Schwartz, Elisabeth F., Silva, Luciano P., Bocca, Anamelia L. and Mortari, Márcia R (2023). Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, 13 (1) 12491, 1-15. doi: 10.1038/s41598-023-38828-w |
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2023 Journal Article A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812 |
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2023 Journal Article Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pHTran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664 |
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2023 Journal Article Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae)Walker, Andrew A., Robinson, Samuel D., Merritt, David J., Cardoso, Fernanda C., Goudarzi, Mohaddeseh Hedayati, Mercedes, Raine S., Eagles, David A., Cooper, Paul, Zdenek, Christina N., Fry, Bryan G., Hall, Donald W., Vetter, Irina and King, Glenn F. (2023). Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae). Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120. doi: 10.1073/pnas.2305871120 |
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2023 Journal Article Two novel mosquitocidal peptides isolated from the venom of the Bahia scarlet tarantula (Lasiodora klugi)Ahmed, Jamila, Walker, Andrew A., Perdomo, Hugo D., Guo, Shaodong, Nixon, Samantha A., Vetter, Irina, Okoh, Hilary I., Shehu, Dalhatu M., Shuaibu, Mohammed N., Ndams, Iliya S., King, Glenn F. and Herzig, Volker (2023). Two novel mosquitocidal peptides isolated from the venom of the Bahia scarlet tarantula (Lasiodora klugi). Toxins, 15 (7) 418, 1-14. doi: 10.3390/toxins15070418 |
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2023 Journal Article Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1aTran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346 |
