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2026 Journal Article No gain from pain: Lack of nociceptor activation suggests no adaptation for defence in the evolution of European viper venomsÜveges, Bálint, Robinson, Samuel D., Schendel, Vanessa, Mizsei, Edvárd, Ćuriċ, Ana, Dimaki, Maria, Ferri, Vincenzo, Petrovan, Silviu, Pozzi, Andrea V., Radonjiċ, Tihomir, Sos, Tibor, Streicher, Jeffrey W., Strugariu, Alexandru, Šunje, Emina, Zamfirescu, Ștefan, Zinenko, Oleksandr, Vetter, Irina and Wüster, Wolfgang (2026). No gain from pain: Lack of nociceptor activation suggests no adaptation for defence in the evolution of European viper venoms. Functional Ecology 1365-2435.70414. doi: 10.1111/1365-2435.70414 |
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2026 Journal Article Electrostatic tuning of Na <sub>V</sub> channel activation by the domain II S3–S4 extracellular loopThapa, Ashvriya, Ragnarsson, Lotten, Tran, Hue, Keramidas, Angelo, Deuis, Jennifer R. and Vetter, Irina (2026). Electrostatic tuning of Na V channel activation by the domain II S3–S4 extracellular loop. The Journal of Physiology JP291286. doi: 10.1113/jp291286 |
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2026 Journal Article Senecioylcholine in Heterometrus spinifer scorpion venom activates vertebrate nicotinic acetylcholine receptorsPrahl, Rosa E., Neupane, Pratik, Salim, Angela A., Lewis, Richard J., Vetter, Irina, Capon, Robert J., King, Glenn F. and Herzig, Volker (2026). Senecioylcholine in Heterometrus spinifer scorpion venom activates vertebrate nicotinic acetylcholine receptors. Frontiers in Arachnid Science, 5 1888189. doi: 10.3389/frchs.2026.1888189 |
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2026 Journal Article Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translationMaganti, Aditya, Rankothge, Ishara, Sakadales, Hunter, Kok, Ethan, Britton, James, Rao, Neil, Shatunova, Svetlana, Shimell, Katherine, Zambrano, Paula Manuela Rojas, Park, Susanna B., Schweitzer, Daniel, Laakso, E-Liisa, Yengo, Loic, Vetter, Irina and Starobova, Hana (2026). Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation. Frontiers in Pharmacology, 17 1842379. doi: 10.3389/fphar.2026.1842379 |
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2026 Journal Article Venom composition of the ant Tetraponera rufonigra reveals insights into the evolution of dimeric ant venom peptidesNaephrai, Suwatjanee, Tran, Hue N. T., Durek, Thomas, Touchard, Axel, Schendel, Vanessa, Atherton, William, Vetter, Irina, Prangkio, Panchika and Robinson, Samuel D. (2026). Venom composition of the ant Tetraponera rufonigra reveals insights into the evolution of dimeric ant venom peptides. Cellular and Molecular Life Sciences. doi: 10.1007/s00018-026-06293-z |
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2026 Journal Article Distinct neuroinflammatory effects of individual chemotherapeutics shape chemotherapy-induced peripheral neuropathy in a novel mouse model of CVAD combination regimenStarobova, Hana, Tay, Nicolette, Nageshwar, Nikhil Inturi, Alshamari, Ammar, Tavares-Ferreira, Diana, Nayler, Samuel, Andersson, Asa, Shatunova, Svetlana and Vetter, Irina (2026). Distinct neuroinflammatory effects of individual chemotherapeutics shape chemotherapy-induced peripheral neuropathy in a novel mouse model of CVAD combination regimen. Pain. doi: 10.1097/j.pain.0000000000004031 |
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2026 Journal Article The Excelsatoxin A-receptor TMEM233 modulates Nav1.8Oprita, George, Meyer, Marvin J. A., Rudolf, Daniel, Stein, Ines C. A. Pombeiro, Deuis, Jennifer R., Tran, Hue N. T., Durek, Thomas, Tabea, Klasfauseweh, Sina, Jami, Waxman, Stephen G., Dib-Hajj, Sulayman D., Babes, Alexandru, Vetter, Irina and Leffler, Andreas (2026). The Excelsatoxin A-receptor TMEM233 modulates Nav1.8. Faseb Journal, 40 (6) e71706. doi: 10.1096/fj.202600787R |
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2026 Journal Article Repeated convergent evolution of bradykinin mimics as defensive toxinsShi, Naiqi, Touchard, Axel, Schendel, Vanessa, Koch, Thomas Lund, Starobova, Hana, Niu, Pancong, Tran, Hue, Ragnarsson, Lotten, Safavi-Hemami, Helena, Vetter, Irina and Robinson, Samuel D. (2026). Repeated convergent evolution of bradykinin mimics as defensive toxins. Science, 391 (6789), 1046-1052. doi: 10.1126/science.adx0452 |
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2026 Journal Article Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelingMoral-Sanz, Javier, Fernández-Carrasco, Isabel, Ramponi, Valentina, Garrido, Amanda, Karbat, Izhar, Cabezas-Sainz, Pablo, Rivera-de-Torre, Esperanza, Elsallabi, Osama, Martín-Hernández, Roberto, López-Aceituno, José L., Price, Nathan L., Sanchez, Laura, Colmenarejo, Gonzalo, Martínez-del-Pozo, Álvaro, Vetter, Irina, Cogolludo, Angel, Perez-Vizcaino, Francisco, Del-Pozo, Jorge, Reuveny, Eitan, Fernández-Rojo, Manuel A., Robbins, Paul D., de Cabo, Rafael, Serrano, Manuel and Ikonomopoulou, Maria P. (2026). Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling. Nature Aging, 6 (2). doi: 10.1038/s43587-025-01030-w |
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2025 Journal Article Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxinsGoudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Suryamohan, Kushal, Lawrence, Nicole, Eagles, David A., Hoang, Huy N., Vetter, Irina, Fairlie, David P., Seshagiri, Somasekar, King, Glenn F. and Walker, Andrew A. (2025). Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins. Proceedings of the National Academy of Sciences, 122 (49) e2513640122, 1-11. doi: 10.1073/pnas.2513640122 |
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2025 Journal Article A hydrophobic loop of the spider-venom peptide Tl1a drives activity at NaV1.8Thapa, Ashvriya, Tran, Hue, Ragnarsson, Lotten, Keramidas, Angelo, Herzig, Volker, Brinkwirth, Nina, Deuis, Jennifer R. and Vetter, Irina (2025). A hydrophobic loop of the spider-venom peptide Tl1a drives activity at NaV1.8. European Journal of Pharmacology, 1001 177751, 177751. doi: 10.1016/j.ejphar.2025.177751 |
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2025 Journal Article A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: overcoming common challengesTay, Nicolette, Alshammari, Ammar, Kaur, Simranpreet, Pettit, Allison, Mu, Erica, Reid, Anna, Winkler, Ingrid, Vetter, Irina and Starobova, Hana (2025). A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: overcoming common challenges. Journal of Neuroscience Methods, 418 110434, 1-13. doi: 10.1016/j.jneumeth.2025.110434 |
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2025 Journal Article Refining the NaV1.7 pharmacophore of a class of venom-derived peptide inhibitors via a combination of in silico screening and rational engineeringSharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Crawford, Theo, Rahnama, Sassan, Undheim, Eivind A. B., Vetter, Irina, Chin, Yanni K.Y. and Mobli, Mehdi (2025). Refining the NaV1.7 pharmacophore of a class of venom-derived peptide inhibitors via a combination of in silico screening and rational engineering. Febs Letters, 599 (12), 1717-1732. doi: 10.1002/1873-3468.70036 |
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2025 Journal Article Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft modelStarobova, Hana, McCalmont, Hannah, Shatunova, Svetlana, Tay, Nicolette, Smith, Christopher M., Robertson, Avril, Winkler, Ingrid, Lock, Richard B. and Vetter, Irina (2025). Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft model. HemaSphere, 9 (3) e70092, 1-3. doi: 10.1002/hem3.70092 |
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2024 Journal Article Adaptive trade-offs between vertebrate defence and insect predation drive Amazonian ant venom evolutionTouchard, Axel, Robinson, Samuel D., Lalague, Hadrien, Ascoet, Steven, Billet, Arnaud, Dejean, Alain, Tene, Nathan J., Petitclerc, Frederic, Troispoux, Valerie, Treilhou, Michel, Bonnafe, Elsa, Vetter, Irina, Vizueta, Joel, Moreau, Corrie S., Orivel, Jerome and Tysklind, Niklas (2024). Adaptive trade-offs between vertebrate defence and insect predation drive Amazonian ant venom evolution. Proceedings of the Royal Society B-Biological Sciences, 291 (2035) 20242184, 1-12. doi: 10.1098/rspb.2024.2184 |
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2024 Journal Article Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipedeSchendel, Vanessa, Hamilton, Brett R., Robinson, Samuel D., Green, Kathryn, Sayre, Marcel E., Brown, Darren, Stow, Jennifer L., Øyen, Jan Philip, Voje, Kjetil L., Millard, S. Sean, Vetter, Irina, Rash, Lachlan D. and Undheim, Eivind A. B. (2024). Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede. Nature Ecology and Evolution, 9 (1) 755, 73-86. doi: 10.1038/s41559-024-02556-9 |
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2024 Journal Article The role of the neuronal microenvironment in sensory function and pain pathophysiologyStarobova, Hana, Alshammari, Ammar, Winkler, Ingrid G. and Vetter, Irina (2024). The role of the neuronal microenvironment in sensory function and pain pathophysiology. Journal of Neurochemistry, 168 (11), 3620-3643. doi: 10.1111/jnc.15724 |
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2024 Journal Article A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradientsThapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757 |
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2024 Journal Article The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathyShatunova, Svetlana, Aktar, Rubina, Peiris, Madusha, Lee, Jia Yu Peppermint, Vetter, Irina and Starobova, Hana (2024). The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy. European Journal of Pharmacology, 979 176818, 1-16. doi: 10.1016/j.ejphar.2024.176818 |
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2024 Journal Article Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugsZdenek, Christina N., Cardoso, Fernanda C., Robinson, Samuel D., Mercedes, Raine S., Raidjõe, Enriko R., Hernandez-Vargas, María José, Jin, Jiayi, Corzo, Gerardo, Vetter, Irina, King, Glenn F., Fry, Bryan G. and Walker, Andrew A. (2024). Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs. iScience, 27 (9) 110723, 1-19. doi: 10.1016/j.isci.2024.110723 |
