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2017 Journal Article Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptideDi Giglio, Maria Giulia , Muttenthaler, Markus, Harpsoe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F. , Gloriam, David E. and Gruber, Christian W. (2017). Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports, 7 (1) 41002, 41002. doi: 10.1038/srep41002 |
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2016 Journal Article Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structureBusnelli, Marta, Kleinau, Gunnar, Muttenthaler, Markus, Stoev, Stoytcho, Manning, Maurice, Bibic, Lucka, Howell, Lesley A., McCormick, Peter J., Di Lascio, Simona, Braida, Daniela, Sala, Mariaelvina, Rovati, G. Enrico, Bellini, Tommaso and Chini, Bice (2016). Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure. Journal of Medicinal Chemistry, 59 (15), 7152-7166. doi: 10.1021/acs.jmedchem.6b00564 |
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2015 Journal Article Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesisMuttenthaler, Markus, Albericio, Fernando and Dawson, Philip E. (2015). Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis. Nature Protocols, 10 (7), 1067-1083. doi: 10.1038/nprot.2015.061 |
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2015 Journal Article Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttlesArranz-Gibert, Pol, Guixer, Bernat, Malakoutikhah, Morteza, Muttenthaler, Markus, Guzman, Fanny, Teixido, Meritxell and Giralt, Ernest (2015). Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles. Journal of the American Chemical Society, 137 (23), 7357-7364. doi: 10.1021/jacs.5b02050 |
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2014 Journal Article Discovery, synthesis, and structure: activity relationships of conotoxinsAkondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11), 1-33. doi: 10.1021/cr400401e |
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2014 Journal Article Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal painDantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165 |
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2013 Journal Article Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand designKoehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52), 21183-21188. doi: 10.1073/pnas.1311183110 |
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2013 Journal Article Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Optical Nanosensing in CellsGemmill, Kelly Boeneman, Muttenthaler, Markus, Delehanty, James B., Stewart, Michael H., Susumu, Kimihiro, Dawson, Philip E. and Medintz, Igor L. (2013). Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Optical Nanosensing in Cells. Analytical and Bioanalytical Chemistry, 405 (19), 6145-6154. doi: 10.1007/s00216-013-6982-2 |
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2012 Journal Article Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discoveryGruber, Christian W., Koehbach, Johannes and Muttenthaler, Markus (2012). Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery. Future Medicinal Chemistry, 4 (14), 1791-1798. doi: 10.4155/FMC.12.108 |
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2012 Journal Article Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New GuineaMuttenthaler, Markus, Dutertre, Sebastien, Wingerd, Joshua S., Aini, John W., Walton, Hugh, Alewood, Paul F. and Lewis, Richard J. (2012). Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea. Nautilus, 126 (2), 47-56. |
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2012 Journal Article Discovery of defense- and neuropeptides in social ants by genome-miningGruber, Christian W. and Muttenthaler, Markus (2012). Discovery of defense- and neuropeptides in social ants by genome-mining. PloS One, 7 (3) e32559, e32559. doi: 10.1371/journal.pone.0032559 |
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2011 Journal Article Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMRMobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011). Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 (50), 11952-11955. doi: 10.1002/anie.201104169 |
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2011 Journal Article Structure-activity studies on alpha-conotoxinsMuttenthaler, Markus, Akondi, Kalyana B. and Alewood, Paul F. (2011). Structure-activity studies on alpha-conotoxins. Current Pharmaceutical Design, 17 (38), 4226-4241. doi: 10.2174/138161211798999384 |
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2010 Journal Article Modulating oxytocin activity and plasma stability by disulfide bond engineeringMuttenthaler, Markus, Andersson, Asa, Dantas de Araujo, Aline, Dekan, Zoltan, Lewis, Richard J. and Alewood, Paul F. (2010). Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry, 53 (24), 8585-8596. doi: 10.1021/jm100989w |
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2010 Journal Article Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsGruber, Christian W., Muttenthaler, Markus and Freissmuth, Michael (2010). Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Current Pharmaceutical Design, 16 (28), 3071-3088. doi: 10.2174/138161210793292474 |
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2010 Journal Article α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptorsGrishin, Anton, Wang, Ching-I. A., Muttenthaler, Markus, Alewood, Paul F., Lewis, Richard J. and Adams, David J. (2010). α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 285 (29), 22254-22263. doi: 10.1074/jbc.M110.111880 |
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2010 Journal Article Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonistsMuttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010). Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 (10), 3514-3522. doi: 10.1021/ja910602h |
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2010 Journal Article p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl groupMuttenthaler, Markus, Ramos, Yesica Garcia, Feytens, Debby, Dantas de Araujo, Aline and Alewood, Paul F. (2010). p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group. Biopolymers, 94 (4), 423-432. doi: 10.1002/bip.21502 |
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2008 Journal Article Selenopeptide chemistryMuttenthaler, Markus and Alewood, Paul F. (2008). Selenopeptide chemistry. Journal of Peptide Science, 14 (12), 1223-1239. doi: 10.1002/psc.1075 |
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2008 Journal Article Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptideDutertre, Sébastien, Croker, Daniel, Daly, Norelle L., Andersson, Åsa, Muttenthaler, Markus, Lumsden, Natalie G., Craik, David J., Alewood, Paul F., Guillon, Gilles and Lewis, Richard J. (2008). Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide. Journal of Biological Chemistry, 283 (11), 7100-7108. doi: 10.1074/jbc.M706477200 |
