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2022

Journal Article

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

2021

Journal Article

Total synthesis of the spider-venom peptide Hi1a

Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112

Total synthesis of the spider-venom peptide Hi1a

2021

Journal Article

The concise guide to pharmacology 2021/22: ion channels

Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M, Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, Fenske, Stefanie, George, Chandy, Goldstein, Steve A. N., Grissmer, Stephan, Ha, Kotdaji ... Zhu, Michael (2021). The concise guide to pharmacology 2021/22: ion channels. British Journal of Pharmacology, 178 (S1), S157-S245. doi: 10.1111/bph.15539

The concise guide to pharmacology 2021/22: ion channels

2021

Journal Article

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Foster, Victoria S., Rash, Lachlan D., King, Glenn F. and Rank, Michelle M. (2021). Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System. Frontiers in cellular neuroscience, 15 738043, 1-16. doi: 10.3389/fncel.2021.738043

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

2021

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3

Kellenberger, Stephan and Rash, Lachlan D. (2021). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3). doi: 10.2218/gtopdb/f118/2021.3

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3

2021

Journal Article

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead

Cristofori-Armstrong, Ben, Budusan, Elena and Rash, Lachlan D. (2021). Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead. Proceedings of the National Academy of Sciences, 118 (8) e2021581118, 1-3. doi: 10.1073/pnas.2021581118

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead

2021

Other Outputs

Neuroprotective agents derived from spider venom peptides

King, Glenn , Rash, Lachlan Douglas, Chassagnon, Irene, Pineda Gonzalez, Sandy Steffany, Widdop, Robert Edward and Ireland, Claudia Ann (2021). Neuroprotective agents derived from spider venom peptides. 10881712.

Neuroprotective agents derived from spider venom peptides

2020

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Kellenberger, Stephan and Rash, Lachlan D. (2020). Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f118/2020.5

Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

2019

Journal Article

The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution

Schendel, Vanessa, Rash, Lachlan D., Jenner, Ronald A. and Undheim, Eivind A. B. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11 (11) 666, 666. doi: 10.3390/toxins11110666

The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution

2019

Journal Article

The Concise Guide to Pharmacology 2019/20: Ion channels

Alexander, Stephen P.H., Mathie, Alistair, Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Becirovic, Elvir, Biel, Martin, Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve A.N., Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike ... Zhu, Michael (2019). The Concise Guide to Pharmacology 2019/20: Ion channels. British Journal of Pharmacology, 176 (S1), S142-S228. doi: 10.1111/bph.14749

The Concise Guide to Pharmacology 2019/20: Ion channels

2019

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Kellenberger, Stephan, Rash, Lachlan D. and Schild, Laurent (2019). Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). doi: 10.2218/gtopdb/f118/2019.4

Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019

Journal Article

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues

Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues

2019

Journal Article

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

2019

Journal Article

D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa Channels

Kakumanu, Rahini, Kuruppu, Sanjaya, Rash, Lachlan, Isbister, Geoffrey, Hodgson, Wayne and Kemp-Harper, Barbara (2019). D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa Channels. Toxins, 11 (4) 197, 197. doi: 10.3390/toxins11040197

D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa Channels

2018

Journal Article

Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans

Silva, Anjana, Cristofori-Armstrong, Ben, Rash, Lachlan D., Hodgson, Wayne C. and Isbister, Geoffrey K. (2018). Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans. Cellular and Molecular Life Sciences, 75 (23), 4465-4478. doi: 10.1007/s00018-018-2893-x

Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans

2018

Journal Article

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

2017

Journal Article

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

Wilson, David, Boyle, Glen M, McIntyre, Lachlan, Nolan, Matthew J, Parsons, Peter G, Smith, Jennifer J, Tribolet, Leon, Loukas, Alex, Liddell, Michael J, Rash, Lachlan D and Daly, Norelle L (2017). The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. Toxins, 9 (11) 346, 1-13. doi: 10.3390/toxins9110346

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

2017

Journal Article

Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms

Cristofori-Armstrong, Ben and Rash, Lachlan D. (2017). Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms. Neuropharmacology, 127, 173-184. doi: 10.1016/j.neuropharm.2017.04.042

Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms

2017

Journal Article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

2017

Journal Article

Modulation of ion channels by cysteine-rich peptides: from sequence to structure

Mobli, Mehdi, Undheim, Eivind A.B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Advances in Pharmacology, 79, 199-223. doi: 10.1016/bs.apha.2017.03.001

Modulation of ion channels by cysteine-rich peptides: from sequence to structure