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2026 Journal Article The isolated thumb domain of acid‐sensing ion channels forms a minimal folding unit enabling ligand binding studiesMishra, Biswa P., Cristofori‐Armstrong, Ben, Budusan, Elena, Golder, Mimi, Butcher, Neville J., Liu, Junyu, Crawford, Theo, Chin, Yanni K.‐Y., Schmidt, Anneka Pereira, Jia, Xinying, Smallwood, Taylor B., Clark, Richard J., Wurm, Jan P., Rash, Lachlan D. and Mobli, Mehdi (2026). The isolated thumb domain of acid‐sensing ion channels forms a minimal folding unit enabling ligand binding studies. Angewandte Chemie, 138 (19) e23977, 1-12. doi: 10.1002/ange.202523977 |
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2026 Journal Article The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1bGolder, Mimi, Butcher, Neville J., Naughton, Jennifer D., Liu, Junyu, Crawford, Theo, Rash, Lachlan D., Mobli, Mehdi and Cristofori-Armstrong, Ben (2026). The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b. European Journal of Pharmacology, 1022 178850, 178850-1022. doi: 10.1016/j.ejphar.2026.178850 |
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2026 Journal Article The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding StudiesMishra, Biswa P., Cristofori‐Armstrong, Ben, Budusan, Elena, Golder, Mimi, Butcher, Neville J., Liu, Junyu, Crawford, Theo, Chin, Yanni K.‐Y., Pereira Schmidt, Anneka, Jia, Xinying, Smallwood, Taylor B., Clark, Richard J., Wurm, Jan P., Rash, Lachlan D. and Mobli, Mehdi (2026). The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. Angewandte Chemie International Edition, 65 (19) e23977, 1-12. doi: 10.1002/anie.202523977 |
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2026 Journal Article Ancient origin and dynamic evolution of bivalent spider toxinsAraya, Robin A, Maurstad, Marius F, Wilson, David T, Rash, Lachlan D, Mobli, Mehdi, Jakobsen, Kjetill S and Undheim, Eivind A B (2026). Ancient origin and dynamic evolution of bivalent spider toxins. Molecular Biology and Evolution, 43 (5) msag076, 5. doi: 10.1093/molbev/msag076 |
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2026 Conference Publication ASIC1a contributes to axonal degeneration via necroptosis in EAERash, Lachlan, Waqar, Maleeha, Khan, Nemat and Butcher, Neville (2026). ASIC1a contributes to axonal degeneration via necroptosis in EAE. MS Australia's 10th Progress in MS Research Conference, Brisbane Australia, Dec 03-05, 2025. LONDON: SAGE PUBLICATIONS LTD. |
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2026 Conference Publication ASIC1a is involved in pro-inflammatory role of astrocytes in EAEWaqar, Maleeha, Rash, Lachlan, Khan, Nemat and Butcher, Neville (2026). ASIC1a is involved in pro-inflammatory role of astrocytes in EAE. MS Australia's 10th Progress in MS Research Conference, Brisbane Australia, Dec 03-05, 2025. LONDON: SAGE PUBLICATIONS LTD. |
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2026 Journal Article Acid-sensing ion channels: structure, function, pharmacology and clinical significanceRash, Lachlan D. and Kellenberger, Stephan (2026). Acid-sensing ion channels: structure, function, pharmacology and clinical significance. Physiological Reviews, 106 (1), 281-362. doi: 10.1152/physrev.00002.2025 |
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2025 Journal Article The concise guide to PHARMACOLOGY 2025/26: Ion channelsAlexander, Stephen P. H., Striessnig, Jörg, Gibb, Alasdair J., Mathie, Alistair A., Veale, Emma L., Kelly, Eamonn, Peach, Chloe J., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Beech, David J., Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Chua, Han Chow, Conner, Alex C., Danahay, Henry, Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta ... Zhu, Michael (2025). The concise guide to PHARMACOLOGY 2025/26: Ion channels. British Journal of Pharmacology, 182 (Supplement 1), S152-S241. doi: 10.1111/bph.70231 |
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2025 Journal Article Ligand-gated ion channels in GtoPdb v.2025.3Wonnacott, Susan, Nicke, Annette, Nakanishi, Shigetada, Mulle, Christophe, Mishina, Masayoshi, Millar, Neil S., Meades, Jessica, Mayer, Mark, Marks, Michael. J., Lynch, Joseph. W., Niesler, Beate, Olsen, Richard, Peineau, Stephane, Watkins, Jeffrey C., Spedding, Michael, Smart, Trevor G., Sivilotti, Lucia G., Sieghart, Werner, Seeburg, Peter, Rudolph, Uwe, Rash, Lachlan D., Peters, John A., Luscher, Bernhard, Lummis, Sarah C. R., Lodge, David, Fountain, Samuel J., Fortuny-Gomez, Anna, Falzoni, Simonetta, Dingledine, Ray ... Barnes, Nicholas M. (2025). Ligand-gated ion channels in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f697/2025.3 |
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2025 Journal Article Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2025.3Kellenberger, Stephan and Rash, Lachlan D. (2025). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f118/2025.3 |
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2025 Conference Publication Acid-sensing ion channel 1a may contribute to both axonal necroptosis and astrogliosis in the pathophysiology of multiple sclerosisRash, Lachlan, Waqar, Maleeha, Butcher, Neville and Khan, Nemat (2025). Acid-sensing ion channel 1a may contribute to both axonal necroptosis and astrogliosis in the pathophysiology of multiple sclerosis. 41st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona Spain, Sep 24-26, 2025. LONDON: SAGE PUBLICATIONS LTD. |
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2024 Journal Article Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variantsCristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas and Rash, Lachlan D. (2024). Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants. Cellular and Molecular Life Sciences, 81 (1) 266, 266. doi: 10.1007/s00018-024-05276-2 |
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2024 Journal Article Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipedeSchendel, Vanessa, Hamilton, Brett R., Robinson, Samuel D., Green, Kathryn, Sayre, Marcel E., Brown, Darren, Stow, Jennifer L., Øyen, Jan Philip, Voje, Kjetil L., Millard, S. Sean, Vetter, Irina, Rash, Lachlan D. and Undheim, Eivind A. B. (2024). Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede. Nature Ecology and Evolution, 9 (1) 755, 73-86. doi: 10.1038/s41559-024-02556-9 |
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2024 Conference Publication Development of venom peptide inhibitors of acid-sensing ion channel 1 as novel therapeutics for multiple sclerosisRash, Lachlan, Waqar, Maleeha, Butcher, Neville and Khan, Nemat (2024). Development of venom peptide inhibitors of acid-sensing ion channel 1 as novel therapeutics for multiple sclerosis. Multiple Sclerosis Australia: Progress in MS Research Conference (MS), Perth, WA, Australia, 29 November-1 December 2023. London, United Kingdom: Sage Publications. |
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2024 Conference Publication Insights into the role of acid sensing ion channels in the pathophysiology of multiple sclerosisWaqar, Maleeha, Khan, Nemat, Butcher, Neville and Rash, Lachlan (2024). Insights into the role of acid sensing ion channels in the pathophysiology of multiple sclerosis. Multiple Sclerosis Australia: Progress in MS Research Conference (MS), Perth, WA, Australia, 29 November-1 December 2023. London, United Kingdom: Sage Publications. |
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2024 Journal Article The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisationBudusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175 |
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2024 Conference Publication Developing novel acid-sensing ion channel inhibitor as a neuroprotective lead for multiple sclerosisKhan, Nemat, Waqar, Maleeha, Butcher, Neville and Rash, Lachlan (2024). Developing novel acid-sensing ion channel inhibitor as a neuroprotective lead for multiple sclerosis. 40th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Copenhagen, Denmark, 18-20 September 2024. London, United Kingdom: Sage Publications. doi: 10.1177/13524585241269220 |
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2024 Conference Publication Understanding the role of acid sensing ion channels as targets of neuroprotection in the pathophysiology of multiple sclerosisWaqar, Maleeha, Rash, Lachlan, Butcher, Neville and Khan, Nemat (2024). Understanding the role of acid sensing ion channels as targets of neuroprotection in the pathophysiology of multiple sclerosis. 40th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Copenhagen, Denmark, 18-20 September 2024. London, United Kingdom: Sage Publications. doi: 10.1177/13524585241269220 |
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2024 Conference Publication In-silico application of structure prediction to peptide mechanism of actionTucker, Isaac, King, Glenn, Saez, Natalie, Deplazes, Evelyne, Rash, Lachlan, Cristofori-Armstrong, Ben and Budusan, Elena (2024). In-silico application of structure prediction to peptide mechanism of action. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarctionRedd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793 |
