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2022 Journal Article Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco and Elli, Stefano (2022). Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**. Chemistry – A European Journal, 29 (1) e202202599, e202202599. doi: 10.1002/chem.202202599 |
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2022 Journal Article An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosidesSee, Nicholas W, Xu, Xiaowen and Ferro, Vito (2022). An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosides. The Journal of Organic Chemistry, 87 (21), 14230-14240. doi: 10.1021/acs.joc.2c01748 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparinGockel, Lukas M., Nekipelov, Katrin, Ferro, Vito, Bendas, Gerd and Schlesinger, Martin (2022). Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin. Cancer Immunology, Immunotherapy, 71 (10), 2523-2533. doi: 10.1007/s00262-022-03186-5 |
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2022 Journal Article Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activityAl‐Buthabhak, Hawraa S., Falasca, Valerio, Yu, Yu, Sobolev, Alexandre N., Skelton, Brian W., Moggach, Stephen A., Ferro, Vito, Al‐Salami, Hani and Baker, Murray V. (2022). Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activity. Applied Organometallic Chemistry, 38 (10) ARTN e6645. doi: 10.1002/aoc.6645 |
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2022 Journal Article Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infectionsChhabra, Mohit, Wilson, Jennifer C., Wu, Liang, Davies, Gideon J., Gandhi, Neha S. and Ferro, Vito (2022). Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections. Chemistry – A European Journal, 28 (11) e202104222, e202104222. doi: 10.1002/chem.202104222 |
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2021 Journal Article Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugateChhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453 |
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2021 Journal Article Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599)Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2021). Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599). Frontiers in Cell and Developmental Biology, 9 678589. doi: 10.3389/fcell.2021.678589 |
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2021 Journal Article A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idoseSee, Nicholas W., Wimmer, Norbert, Krenske, Elizabeth H. and Ferro, Vito (2021). A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose. European Journal of Organic Chemistry, 2021 (10), 1575-1584. doi: 10.1002/ejoc.202100042 |
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2021 Journal Article Inhibition of tumor-host cell interactions using synthetic heparin mimeticsGockel, Lukas M., Heyes, Martin, Li, Honglian, Al Nahain, Abdullah, Gorzelanny, Christian, Schlesinger, Martin, Holdenrieder, Stefan, Li, Jin-Ping, Ferro, Vito and Bendas, Gerd (2021). Inhibition of tumor-host cell interactions using synthetic heparin mimetics. ACS Applied Materials and Interfaces, 13 (6), 7080-7093. doi: 10.1021/acsami.0c20744 |
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2021 Journal Article Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domainSchuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R. and Gandhi, Neha S. (2021). Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Computational and Structural Biotechnology Journal, 19, 2806-2818. doi: 10.1016/j.csbj.2021.05.002 |
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2020 Journal Article GlycoTorch Vina: docking designed and tested for glycosaminoglycansBoittier, Eric D., Burns, Jed M., Gandhi, Neha S. and Ferro, Vito (2020). GlycoTorch Vina: docking designed and tested for glycosaminoglycans. Journal of Chemical Information and Modeling, 60 (12), 6328-6343. doi: 10.1021/acs.jcim.0c00373 |
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2020 Journal Article Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activityNahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2020). Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity. Macromolecular Bioscience, 20 (9) 2000110, e2000110. doi: 10.1002/mabi.202000110 |
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2020 Journal Article Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivoHuang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2020). Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo. Frontiers in Cell and Developmental Biology, 8 599, 599. doi: 10.3389/fcell.2020.00599 |
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2020 Journal Article PI-88 and related heparan sulfate mimeticsChhabra, Mohit and Ferro, Vito (2020). PI-88 and related heparan sulfate mimetics. Advances in Experimental Medicine and Biology, 1221, 473-491. doi: 10.1007/978-3-030-34521-1_19 |
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2020 Journal Article Synthesis of cholesterol glycoconjugates for targeted liposomal drug deliveryNguyen, Huong, Pan, Yuchen, Nahain, Abdullah Al, Clarke, Daniel, McMillan, Nigel A. and Ferro, Vito (2020). Synthesis of cholesterol glycoconjugates for targeted liposomal drug delivery. Trends in Carbohydrate Research, 12 (3), 1-9. |
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2019 Journal Article Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004 |
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2019 Journal Article PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 miceSupramaniam, Aroon, Bielefeldt-Ohmann, Helle, Rudd, Penny A., Webster, Julie, Ferro, Vito and Herrero, Lara J. (2019). PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice. PLoS ONE, 14 (6) e0217998, e0217998. doi: 10.1371/journal.pone.0217998 |
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2019 Journal Article In vitro enzymatic digestibility of glutaraldehyde-crosslinked chitosan nanoparticles in lysozyme solution and their applicability in pulmonary drug deliveryIslam, Nazrul, Wang, Hui, Maqbool, Faheem and Ferro, Vito (2019). In vitro enzymatic digestibility of glutaraldehyde-crosslinked chitosan nanoparticles in lysozyme solution and their applicability in pulmonary drug delivery. Molecules, 24 (7) 1271, 1271. doi: 10.3390/molecules24071271 |
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2019 Journal Article Cross-species analysis of glycosaminoglycan binding proteins reveals some animal models are “more equal” than othersBoittier, Eric, Gandhi, Neha, Ferro, Vito and Coombe, Deirdre (2019). Cross-species analysis of glycosaminoglycan binding proteins reveals some animal models are “more equal” than others. Molecules, 24 (5) 924, 924. doi: 10.3390/molecules24050924 |
