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Featured 2022 Journal Article Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interactionGuimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293 |
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Featured 2021 Journal Article From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactionsChhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125 |
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Featured 2020 Journal Article Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparinMycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319 |
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Featured 2020 Journal Article Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharideWu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c |
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Featured 2019 Journal Article Anticoagulant heparin mimetics via RAFT PolymerizationNahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688 |
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Featured 2019 Journal Article Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regionsHe, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328 |
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Featured 2012 Journal Article Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasisFerro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h |
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2024 Journal Article Sulfated Alginate for Biomedical ApplicationsMutch, Alexandra L., Yang, Jiankun, Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Sulfated Alginate for Biomedical Applications. Macromolecular Bioscience, e2400237. doi: 10.1002/mabi.202400237 |
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2024 Journal Article Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487 |
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2024 Journal Article Site-Selective Photobromination of O-Acetylated Carbohydrates in BenzotrifluorideZhang, Guoqing, See, Nicholas W., Wimmer, Norbert, Godinez, Michael J., Cameron, Scott A., Furneaux, Richard H. and Ferro, Vito (2024). Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride. Organic Letters, 26 (28), 5956-5960. doi: 10.1021/acs.orglett.4c01898 |
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2024 Journal Article Origins of Temperature‐Dependent Anomeric Selectivity in Glycosylations with an L‐Idose ThioglycosideSee, Nicholas W., Roseli, Ras Baizureen, Wimmer, Norbert, Le, Tri T., Krenske, Elizabeth H. and Ferro, Vito (2024). Origins of Temperature‐Dependent Anomeric Selectivity in Glycosylations with an L‐Idose Thioglycoside. Chemistry – A European Journal e202400331. doi: 10.1002/chem.202400331 |
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2024 Journal Article Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne VirusesNahain, Abdullah Al, Li, Jinlin, Modhiran, Naphak, Watterson, Daniel, Li, Jin-ping, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2024). Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses. ACS Applied Bio Materials, 7 (5), 2862-2871. doi: 10.1021/acsabm.3c01223 |
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2024 Journal Article Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·pyMutch, Alexandra L., Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py. Carbohydrate Polymers, 324 121488, 1-9. doi: 10.1016/j.carbpol.2023.121488 |
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2023 Journal Article Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screeningLi, Binjie, Zhang, Tianji, Cao, Hui, Ferro, Vito, Li, Jinping and Yu, Mingjia (2023). Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screening. International Journal of Molecular Sciences, 24 (22) 16115, 1-16. doi: 10.3390/ijms242216115 |
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2023 Journal Article C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivitySee, Nicholas W., Pierens, Gregory K., Krenske, Elizabeth and Ferro, Vito (2023). C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivity. Synthesis, 56 (06), 966-974. doi: 10.1055/a-2149-4586 |
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2023 Journal Article Siderophore conjugates to combat antibiotic-resistant bacteriaRayner, Beth, Verderosa, Anthony D., Ferro, Vito and Blaskovich, Mark A. T. (2023). Siderophore conjugates to combat antibiotic-resistant bacteria. RSC Medicinal Chemistry, 14 (5), 800-822. doi: 10.1039/d2md00465h |
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2023 Journal Article Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanaseDoherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619 |
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2023 Journal Article A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndromeHemsley, Kim M., Beard, Helen, Doherty, Gareth G., Mubarokah, Siti, Nazri, Nazzmer and Ferro, Vito (2023). A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome. Molecular Genetics and Metabolism, 138 (2) 107145, 59-59. doi: 10.1016/j.ymgme.2022.107145 |
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2022 Journal Article Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaDBoittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158 |
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2022 Journal Article Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco and Elli, Stefano (2022). Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**. Chemistry – A European Journal, 29 (1) e202202599, e202202599. doi: 10.1002/chem.202202599 |
