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2022 Journal Article Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interactionGuimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293 |
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2021 Journal Article From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactionsChhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125 |
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2020 Journal Article Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparinMycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319 |
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2020 Journal Article Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharideWu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c |
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2019 Journal Article Anticoagulant heparin mimetics via RAFT PolymerizationNahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688 |
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2019 Journal Article Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regionsHe, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328 |
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2012 Journal Article Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasisFerro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h |
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2025 Journal Article Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndromeTan, Sher Li, Neumann, Daniel, Trim, Paul J., Hewson, Laura J., Mustaffar, Nooramirah Farhana, He, Qi Qi, Wimmer, Norbert, Snel, Marten F., Ferro, Vito, O'Keefe, Louise V., Hemsley, Kim M. and Lau, Adeline A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Molecular Genetics and Metabolism, 145 (2) 109112, 109112. doi: 10.1016/j.ymgme.2025.109112 |
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2025 Journal Article Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activityNi, Minghong, Parafioriti, Michela, Esposito, Emiliano, Danzi, Margherita, Cano, Ornela, Muzi, Laura, Kayal, Yasmin, Ferro, Vito, Vlodavsky, Israel, Elli, Stefano, Naggi, Annamaria, Petitou, Maurice and Guerrini, Marco (2025). Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity. Bioorganic & Medicinal Chemistry, 118 118052, 118052-118. doi: 10.1016/j.bmc.2024.118052 |
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2025 Journal Article A Novel Series of Synthetic Heparin-Mimetics–Itaconic Acid-Containing Copolymers for Targeting Tumor Cell Coagulability and MetastasisNekipelov, Katrin, Nahain, Abdullah Al, Otto, Sven, Xu, Yongbin, Li, Jin-Ping, Letunica, Natasha, Collett, Simon, Attard, Chantal, Monagle, Paul, Vamvounis, George, Tsanaktsidis, John, Ferro, Vito and Bendas, Gerd (2025). A Novel Series of Synthetic Heparin-Mimetics–Itaconic Acid-Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis. Macromolecular Bioscience. doi: 10.1002/mabi.202400633 |
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2024 Journal Article Synthetic access to l-guluronic acid via fluorine-directed C-5 epimerizationSee, Nicholas W., Wimmer, Norbert, Zhang, Guoqing, Krenske, Elizabeth H. and Ferro, Vito (2024). Synthetic access to l-guluronic acid via fluorine-directed C-5 epimerization. The Journal of Organic Chemistry, 89 (24), 17941-17949. doi: 10.1021/acs.joc.4c01257 |
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2024 Journal Article Synthesis of a deuterated disaccharide internal standard for LC-MS/MS quantitation of heparan sulfate in biological samplesPan, Yuchen, He, Qi Qi, Wimmer, Norbert and Ferro, Vito (2024). Synthesis of a deuterated disaccharide internal standard for LC-MS/MS quantitation of heparan sulfate in biological samples. Carbohydrate Research, 545 109270, 1-8. doi: 10.1016/j.carres.2024.109270 |
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2024 Journal Article Origins of temperature‐dependent anomeric selectivity in glycosylations with an L‐idose thioglycosideSee, Nicholas W., Roseli, Ras Baizureen, Wimmer, Norbert, Le, Tri T., Krenske, Elizabeth H. and Ferro, Vito (2024). Origins of temperature‐dependent anomeric selectivity in glycosylations with an L‐idose thioglycoside. Chemistry – A European Journal, 30 (52) e202400331, e202400331. doi: 10.1002/chem.202400331 |
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2024 Journal Article Sulfated alginate for biomedical applicationsMutch, Alexandra L., Yang, Jiankun, Ferro, Vito, A., Anitha and Grøndahl, Lisbeth (2024). Sulfated alginate for biomedical applications. Macromolecular Bioscience, 24 (11) 2400237, e2400237. doi: 10.1002/mabi.202400237 |
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2024 Journal Article Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487 |
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2024 Journal Article Site-Selective Photobromination of O-Acetylated Carbohydrates in BenzotrifluorideZhang, Guoqing, See, Nicholas W., Wimmer, Norbert, Godinez, Michael J., Cameron, Scott A., Furneaux, Richard H. and Ferro, Vito (2024). Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride. Organic Letters, 26 (28), 5956-5960. doi: 10.1021/acs.orglett.4c01898 |
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2024 Journal Article Antiviral activities of heparan sulfate mimetic RAFT polymers against mosquito-borne virusesNahain, Abdullah Al, Li, Jinlin, Modhiran, Naphak, Watterson, Daniel, Li, Jin-ping, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2024). Antiviral activities of heparan sulfate mimetic RAFT polymers against mosquito-borne viruses. ACS Applied Bio Materials, 7 (5), 2862-2871. doi: 10.1021/acsabm.3c01223 |
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2024 Journal Article Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·pyMutch, Alexandra L., Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py. Carbohydrate Polymers, 324 121488, 1-9. doi: 10.1016/j.carbpol.2023.121488 |
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2024 Journal Article A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS-CoV-2 Infection and Ameliorates Viral-Induced InflammationLing, Jiaxin, Lundkvist, Åke, Guerrini, Marco, Ferro, Vito, Li, Jin-Ping and Li, Jinlin (2024). A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS-CoV-2 Infection and Ameliorates Viral-Induced Inflammation. Advanced Science, 12 (6) 2411737. doi: 10.1002/advs.202411737 |
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2023 Journal Article Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screeningLi, Binjie, Zhang, Tianji, Cao, Hui, Ferro, Vito, Li, Jinping and Yu, Mingjia (2023). Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screening. International Journal of Molecular Sciences, 24 (22) 16115, 1-16. doi: 10.3390/ijms242216115 |
