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2022 Journal Article Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interactionGuimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293 |
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2021 Journal Article From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactionsChhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125 |
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2020 Journal Article Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparinMycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319 |
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2020 Journal Article Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharideWu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c |
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2019 Journal Article Anticoagulant heparin mimetics via RAFT PolymerizationNahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688 |
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2019 Journal Article Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regionsHe, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328 |
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2012 Journal Article Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasisFerro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h |
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2026 Journal Article Synthesis of a C-2 functionalized l-iduronic acid derivative as a candidate pharmacological chaperone for MPS II (Hunter syndrome)Nagendra, Vaibhavi, Mohamed, Shifaza, See, Nicholas W., Wimmer, Norbert, Neumann, Daniel, Trim, Paul J., Snel, Marten, Brock, Aidan J., Clegg, Jack K., Gandhi, Neha S., Hemsley, Kim M., Lau, Adeline A. and Ferro, Vito (2026). Synthesis of a C-2 functionalized l-iduronic acid derivative as a candidate pharmacological chaperone for MPS II (Hunter syndrome). Chemistry - An Asian Journal, 21 (11) e70823. doi: 10.1002/asia.70823 |
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2026 Journal Article Fully Synthetic Non-Carbohydrate Heparin Mimetics—Perspectives for Therapeutic Anticoagulation and Beyond?Nekipelov, Katrin, Ferro, Vito and Bendas, Gerd (2026). Fully Synthetic Non-Carbohydrate Heparin Mimetics—Perspectives for Therapeutic Anticoagulation and Beyond?. Archiv der Pharmazie, 359 (4) e70239. doi: 10.1002/ardp.70239 |
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2026 Journal Article Comparing heparin and heparin mimetics in targeting immunomodulatory proteins from platelets to activate T cell-dependent immune response in oncologyNekipelov, Katrin, Otto, Sven, Henseler, Maximilian, Vidal-y-Sy, Sabine, Nahain, Abdullah Al, Gorzelanny, Christian, Ferro, Vito and Bendas, Gerd (2026). Comparing heparin and heparin mimetics in targeting immunomodulatory proteins from platelets to activate T cell-dependent immune response in oncology. ACS Pharmacology & Translational Science, 9 (4) acsptsci.5c00722, 954-965. doi: 10.1021/acsptsci.5c00722 |
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2026 Conference Publication Heparin and synthetic heparin mimetics – do they act as potential immunomodulators in an in vitro metastatic context?Nekipelov, K., Henseler, M., Gockel, L. M., Schlesinger, M., Ferro, V. and Bendas, G. (2026). Heparin and synthetic heparin mimetics – do they act as potential immunomodulators in an in vitro metastatic context?. GTH Congress 2026 – 70th Annual Meeting of the Society of Thrombosis and Haemostasis Research, Bonn, Germany, 17 - 20 February 2026. Stuttgart, Germany: Schattauer GmbH. doi: 10.1055/s-0045-1814625 |
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2025 Journal Article Purple light-promoted ferrier photobromination of O-benzoylated carbohydrates in benzotrifluorideZhang, Guoqing, See, Nicholas W., Sharma S., Ajay, Wimmer, Norbert, Godinez, Michael J., Cameron, Scott A., Furneaux, Richard H. and Ferro, Vito (2025). Purple light-promoted ferrier photobromination of O-benzoylated carbohydrates in benzotrifluoride. The Journal of Organic Chemistry, 90 (47), 16885-16890. doi: 10.1021/acs.joc.5c01913 |
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2025 Journal Article Efficient synthesis of fluorogenic substrates for mucopolysaccharidosis (MPS) IIIA and IIIB via aromatic α-glycosylation with thioglycosyl donorsPan, Yuchen, Doherty, Gareth G., Al Nahain, Abdullah, Wimmer, Norbert, Lau, Adeline A., Hemsley, Kim M. and Ferro, Vito (2025). Efficient synthesis of fluorogenic substrates for mucopolysaccharidosis (MPS) IIIA and IIIB via aromatic α-glycosylation with thioglycosyl donors. Organic and Biomolecular Chemistry, 23 (26), 6446-6455. doi: 10.1039/d5ob00699f |
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2025 Journal Article Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndromeTan, Sher Li, Neumann, Daniel, Trim, Paul J., Hewson, Laura J., Mustaffar, Nooramirah Farhana, He, Qi Qi, Wimmer, Norbert, Snel, Marten F., Ferro, Vito, O'Keefe, Louise V., Hemsley, Kim M. and Lau, Adeline A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Molecular Genetics and Metabolism, 145 (2) 109112, 1-12. doi: 10.1016/j.ymgme.2025.109112 |
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2025 Journal Article Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCsAl-Buthabhak, Hawraa S., Al-Ameed, Karrar, Yu, Yu, Sobolev, Alexandre N., Moggach, Stephen A., Al-Salami, Hani, Ferro, Vito and Baker, Murray V. (2025). Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCs. RSC Advances, 15 (23), 18123-18141. doi: 10.1039/d5ra02655e |
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2025 Journal Article A novel series of synthetic heparin-mimetics–itaconic acid-containing copolymers for targeting tumor cell coagulability and metastasisNekipelov, Katrin, Nahain, Abdullah Al, Otto, Sven, Xu, Yongbin, Li, Jin-Ping, Letunica, Natasha, Collett, Simon, Attard, Chantal, Monagle, Paul, Vamvounis, George, Tsanaktsidis, John, Ferro, Vito and Bendas, Gerd (2025). A novel series of synthetic heparin-mimetics–itaconic acid-containing copolymers for targeting tumor cell coagulability and metastasis. Macromolecular Bioscience, 25 (7) 2400633. doi: 10.1002/mabi.202400633 |
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2025 Journal Article A heparan sulfate mimetic RAFT copolymer inhibits SARS-CoV-2 infection and ameliorates viral-induced inflammationLing, Jiaxin, Lundkvist, Åke, Guerrini, Marco, Ferro, Vito, Li, Jin-Ping and Li, Jinlin (2025). A heparan sulfate mimetic RAFT copolymer inhibits SARS-CoV-2 infection and ameliorates viral-induced inflammation. Advanced Science, 12 (6) 2411737, e2411737. doi: 10.1002/advs.202411737 |
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2025 Journal Article Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activityNi, Minghong, Parafioriti, Michela, Esposito, Emiliano, Danzi, Margherita, Cano, Ornela, Muzi, Laura, Kayal, Yasmin, Ferro, Vito, Vlodavsky, Israel, Elli, Stefano, Naggi, Annamaria, Petitou, Maurice and Guerrini, Marco (2025). Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity. Bioorganic and Medicinal Chemistry, 118 118052, 1-13. doi: 10.1016/j.bmc.2024.118052 |
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2024 Journal Article Synthetic access to l-guluronic acid via fluorine-directed C-5 epimerizationSee, Nicholas W., Wimmer, Norbert, Zhang, Guoqing, Krenske, Elizabeth H. and Ferro, Vito (2024). Synthetic access to l-guluronic acid via fluorine-directed C-5 epimerization. The Journal of Organic Chemistry, 89 (24), 17941-17949. doi: 10.1021/acs.joc.4c01257 |
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2024 Journal Article Synthesis of a deuterated disaccharide internal standard for LC-MS/MS quantitation of heparan sulfate in biological samplesPan, Yuchen, He, Qi Qi, Wimmer, Norbert and Ferro, Vito (2024). Synthesis of a deuterated disaccharide internal standard for LC-MS/MS quantitation of heparan sulfate in biological samples. Carbohydrate Research, 545 109270, 1-8. doi: 10.1016/j.carres.2024.109270 |
