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2023 Journal Article Siderophore conjugates to combat antibiotic-resistant bacteriaRayner, Beth, Verderosa, Anthony D., Ferro, Vito and Blaskovich, Mark A. T. (2023). Siderophore conjugates to combat antibiotic-resistant bacteria. RSC Medicinal Chemistry, 14 (5), 800-822. doi: 10.1039/d2md00465h |
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2023 Journal Article Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanaseDoherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619 |
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2023 Conference Publication A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndromeHemsley, Kim M., Beard, Helen, Doherty, Gareth G., Mubarokah, Siti, Nazri, Nazzmer and Ferro, Vito (2023). A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome. WORLDSymposiumTM 2023 19th Annual Research Meeting & Scientific Sessions, Orlando, FL United States, 22 - 26 February 2023. Waltham, MA United States: Academic Press. doi: 10.1016/j.ymgme.2022.107145 |
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2023 Book Chapter An enzymatic activity assay for heparanase that is useful for evaluating clinically relevant inhibitors and studying kineticsHammond, Edward and Ferro, Vito (2023). An enzymatic activity assay for heparanase that is useful for evaluating clinically relevant inhibitors and studying kinetics. Methods in molecular biology. (pp. 227-238) edited by Nikos K. Karamanos. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-2946-8_16 |
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2022 Journal Article Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaDBoittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158 |
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2022 Journal Article Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco and Elli, Stefano (2022). Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**. Chemistry – A European Journal, 29 (1) e202202599, e202202599. doi: 10.1002/chem.202202599 |
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2022 Journal Article An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosidesSee, Nicholas W, Xu, Xiaowen and Ferro, Vito (2022). An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosides. The Journal of Organic Chemistry, 87 (21), 14230-14240. doi: 10.1021/acs.joc.2c01748 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparinGockel, Lukas M., Nekipelov, Katrin, Ferro, Vito, Bendas, Gerd and Schlesinger, Martin (2022). Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin. Cancer Immunology, Immunotherapy, 71 (10), 2523-2533. doi: 10.1007/s00262-022-03186-5 |
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2022 Journal Article Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activityAl‐Buthabhak, Hawraa S., Falasca, Valerio, Yu, Yu, Sobolev, Alexandre N., Skelton, Brian W., Moggach, Stephen A., Ferro, Vito, Al‐Salami, Hani and Baker, Murray V. (2022). Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activity. Applied Organometallic Chemistry, 38 (10) e6645. doi: 10.1002/aoc.6645 |
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2022 Journal Article Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infectionsChhabra, Mohit, Wilson, Jennifer C., Wu, Liang, Davies, Gideon J., Gandhi, Neha S. and Ferro, Vito (2022). Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections. Chemistry – A European Journal, 28 (11) e202104222, e202104222. doi: 10.1002/chem.202104222 |
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2021 Journal Article Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugateChhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453 |
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2021 Journal Article Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599)Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2021). Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599). Frontiers in Cell and Developmental Biology, 9 678589. doi: 10.3389/fcell.2021.678589 |
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2021 Journal Article A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idoseSee, Nicholas W., Wimmer, Norbert, Krenske, Elizabeth H. and Ferro, Vito (2021). A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose. European Journal of Organic Chemistry, 2021 (10), 1575-1584. doi: 10.1002/ejoc.202100042 |
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2021 Journal Article Inhibition of tumor-host cell interactions using synthetic heparin mimeticsGockel, Lukas M., Heyes, Martin, Li, Honglian, Al Nahain, Abdullah, Gorzelanny, Christian, Schlesinger, Martin, Holdenrieder, Stefan, Li, Jin-Ping, Ferro, Vito and Bendas, Gerd (2021). Inhibition of tumor-host cell interactions using synthetic heparin mimetics. ACS Applied Materials and Interfaces, 13 (6), 7080-7093. doi: 10.1021/acsami.0c20744 |
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2021 Journal Article Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domainSchuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R. and Gandhi, Neha S. (2021). Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Computational and Structural Biotechnology Journal, 19, 2806-2818. doi: 10.1016/j.csbj.2021.05.002 |
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2020 Journal Article GlycoTorch Vina: docking designed and tested for glycosaminoglycansBoittier, Eric D., Burns, Jed M., Gandhi, Neha S. and Ferro, Vito (2020). GlycoTorch Vina: docking designed and tested for glycosaminoglycans. Journal of Chemical Information and Modeling, 60 (12), 6328-6343. doi: 10.1021/acs.jcim.0c00373 |
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2020 Journal Article Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activityNahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2020). Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity. Macromolecular Bioscience, 20 (9) 2000110, e2000110. doi: 10.1002/mabi.202000110 |
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2020 Journal Article Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivoHuang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2020). Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo. Frontiers in Cell and Developmental Biology, 8 599, 599. doi: 10.3389/fcell.2020.00599 |
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2020 Other Outputs Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interactionGuimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T, Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D.J., Chhabra, Mohit, Young, Paul R., Lima, Marcelo A., A.Yates, Edwin, Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Hammond, Edward, Dredge, Keith, Wilkinson, Tom M.A. ... Turnbull, Jeremy E. (2020). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction. doi: 10.1101/2020.06.24.169334 |
