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2023 Journal Article Antigen specific immunotherapy to restore antigen-specific tolerance in type 1 diabetes and Graves’ diseaseZala, Aakansha and Thomas, Ranjeny (2023). Antigen specific immunotherapy to restore antigen-specific tolerance in type 1 diabetes and Graves’ disease. Clinical and Experimental Immunology, 211 (2), 164-175. doi: 10.1093/cei/uxac115 |
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2022 Journal Article Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associationsMuralidharan, Sachin, Ali, Sarah, Yang, Lilin, Badshah, Joshua, Zahir, Syeda Farah, Ali, Rubbiya A., Chandra, Janin, Frazer, Ian H., Thomas, Ranjeny and Mehdi, Ahmed M. (2022). Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associations. Scientific Reports, 12 (1) 18710, 1-19. doi: 10.1038/s41598-022-21988-6 |
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2022 Journal Article Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritisSonigra, Amee, Nel, Hendrik J., Wehr, Pascale, Ramnoruth, Nishta, Patel, Swati, van Schie, Karin A., Bladen, Maxwell W., Mehdi, Ahmed M., Tesiram, Joanne, Talekar, Meghna, Rossjohn, Jamie, Reid, Hugh H., Stuurman, Frederik E., Roberts, Helen, Vecchio, Phillip, Gourley, Ian, Rigby, Mark, Becart, Stephane, Toes, Rene E.M., Scherer, Hans Ulrich, Lê Cao, Kim-Anh, Campbell, Kim and Thomas, Ranjeny (2022). Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. JCI Insight, 7 (20) e160964, 1-18. doi: 10.1172/jci.insight.160964 |
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2022 Journal Article Global epidemiology of rheumatoid arthritisFinckh, Axel, Gilbert, Benoît, Hodkinson, Bridget, Bae, Sang-Cheol, Thomas, Ranjeny, Deane, Kevin D., Alpizar-Rodriguez, Deshiré and Lauper, Kim (2022). Global epidemiology of rheumatoid arthritis. Nature Reviews Rheumatology, 18 (10), 591-602. doi: 10.1038/s41584-022-00827-y |
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2022 Journal Article Immune tolerance therapies for autoimmune diseases: shifting the goalpost to cureSharkey, Patrick and Thomas, Ranjeny (2022). Immune tolerance therapies for autoimmune diseases: shifting the goalpost to cure. Current Opinion in Pharmacology, 65 102242, 102242. doi: 10.1016/j.coph.2022.102242 |
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2022 Journal Article Secreted NF-κB suppressive microbial metabolites modulate gut inflammationGiri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646 |
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2022 Journal Article Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer stainingPatel, Swati, Ramnoruth, Nishta, Wehr, Pascale, Rossjohn, Jamie, Reid, Hugh H., Campbell, Kim, Nel, Hendrik J. and Thomas, Ranjeny (2022). Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer staining. Clinical and Experimental Immunology, 207 (1), 72-83. doi: 10.1093/cei/uxab008 |
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2022 Journal Article Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitopeBuckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2022). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506 |
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2021 Journal Article IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetesGreenbaum, Carla J., Serti, Elisavet, Lambert, Katharina, Weiner, Lia J., Kanaparthi, Sai, Lord, Sandra, Gitelman, Stephen E., Wilson, Darrell M., Gaglia, Jason L., Griffin, Kurt J., Russell, William E., Raskin, Philip, Moran, Antoinette, Willi, Steven M., Tsalikian, Eva, DiMeglio, Linda A., Herold, Kevan C., Moore, Wayne V., Goland, Robin, Harris, Mark, Craig, Maria E., Schatz, Desmond A., Baidal, David A., Rodriguez, Henry, Utzschneider, Kristina M., Nel, Hendrik J., Soppe, Carol L., Boyle, Karen D., Cerosaletti, Karen ... Sanda, Srinath (2021). IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. JCI Insight, 6 (21) e150074. doi: 10.1172/jci.insight.150074 |
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2021 Journal Article Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registrySparks, Jeffrey A, Wallace, Zachary S, Seet, Andrea M, Gianfrancesco, Milena A, Izadi, Zara, Hyrich, Kimme L, Strangfeld, Anja, Gossec, Laure, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Wise, Leanna, Gilbert, Emily L, Duarte-Garciá, Ali, Valenzuela-Almada, Maria O, Pons-Estel, Guillermo J, Isnardi, Carolina A, Berbotto, Guillermo A, Hsu, Tiffany Y-T, D'Silva, Kristin M, Patel, Naomi J, Kearsley-Fleet, Lianne, Schäfer, Martin, Ribeiro, Sandra Lúcia Euzébio ... Yazdany, Jinoos (2021). Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry. Annals of the Rheumatic Diseases, 80 (9), 1137-1146. doi: 10.1136/annrheumdis-2021-220418 |
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2021 Journal Article Preclinical models of arthritis for studying immunotherapy and immune toleranceMeehan, Gavin R., Thomas, Ranjeny, Al Khabouri, Shaima, Wehr, Pascale, Hilkens, Catharien M.U., Wraith, David C., Sieghart, Daniela, Bonelli, Michael, Nagy, György, Garside, Paul, Tough, David F., Lewis, Huw D. and Brewer, James M. (2021). Preclinical models of arthritis for studying immunotherapy and immune tolerance. Annals of the Rheumatic Diseases, 80 (10), 1268-1277. doi: 10.1136/annrheumdis-2021-220043 |
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2021 Journal Article Overcoming obstacles in the development of antigen-specific immunotherapies for Type 1 diabetesThomas, Ranjeny, Carballido, José M., Wesley, Johnna D. and Ahmed, Simi T. (2021). Overcoming obstacles in the development of antigen-specific immunotherapies for Type 1 diabetes. Frontiers in Immunology, 12 730414, 730414. doi: 10.3389/fimmu.2021.730414 |
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2021 Journal Article Potential for antigen-specific tolerizing immunotherapy in systematic lupus erythematosusRobinson, Sean and Thomas, Ranjeny (2021). Potential for antigen-specific tolerizing immunotherapy in systematic lupus erythematosus. Frontiers in Immunology, 12 654701, 654701. doi: 10.3389/fimmu.2021.654701 |
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2021 Journal Article Mediation of interleukin-23 and tumor necrosis factor–driven reactive arthritis by Chlamydia-infected macrophages in SKG miceRomand, Xavier, Liu, Xiao, Rahman, M. Arifur, Bhuyan, Zaied Ahmed, Douillard, Claire, Arora Kedia, Reena, Stone, Nathan, Roest, Dominique, Chew, Zi Huai, Cameron, Amy J., Rehaume, Linda M., Bozon, Aurélie, Habib, Mohammed, Armitage, Charles W., Nguyen, Minh Vu Chuong, Favier, Bertrand, Beagley, Kenneth, Maurin, Max, Gaudin, Philippe, Thomas, Ranjeny, Wells, Timothy J. and Baillet, Athan (2021). Mediation of interleukin-23 and tumor necrosis factor–driven reactive arthritis by Chlamydia-infected macrophages in SKG mice. Arthritis and Rheumatology, 73 (7) art.41653, 1200-1210. doi: 10.1002/art.41653 |
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2021 Journal Article Ankylosing spondylitis: an autoimmune or autoinflammatory disease?Mauro, Daniele, Thomas, Ranjeny, Guggino, Giuliana, Lories, Rik, Brown, Matthew A. and Ciccia, Francesco (2021). Ankylosing spondylitis: an autoimmune or autoinflammatory disease?. Nature Reviews Rheumatology, 17 (7), 387-404. doi: 10.1038/s41584-021-00625-y |
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2021 Journal Article Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosisGuggino, Giuliana, Mauro, Daniele, Rizzo, Aroldo, Alessandro, Riccardo, Raimondo, Stefania, Bergot, Anne-Sophie, Rahman, M Arifur, Ellis, Jonathan J., Milling, Simon, Lories, Rik, Elewaut, Dirk, Brown, Matthew A., Thomas, Ranjeny and Ciccia, Francesco (2021). Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosis. Arthritis and Rheumatology, 73 (7) art.41644, 1189-1199. doi: 10.1002/art.41644 |
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2021 Journal Article A patient-centered knowledge translation tool for treat-to-target strategy in rheumatoid arthritis: patient and rheumatologist perspectivesBenham, Helen, Chiu, Hedva, Tesiram, Joanne, Mehdi, Ahmed, Landsberg, Peter, Grosman, Sergei, Harrison, Andrew, Nash, Peter, Thomas, Ranjeny, Langbecker, Danette and Van Driel, Mieke (2021). A patient-centered knowledge translation tool for treat-to-target strategy in rheumatoid arthritis: patient and rheumatologist perspectives. International Journal of Rheumatic Diseases, 24 (3), 355-363. doi: 10.1111/1756-185x.14051 |
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2021 Journal Article Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in miceMoentadj, Rabia, Wang, Yiwen, Bowerman, Kate, Rehaume, Linda, Nel, Hendrik, O Cuiv, Paraic, Stephens, Juliette, Baharom, Amalina, Maradana, Muralidhara, Lakis, Vanessa, Morrison, Mark, Wells, Timothy, Hugenholtz, Philip, Benham, Helen, Le Cao, Kim-Anh and Thomas, Ranjeny (2021). Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice. Annals of the Rheumatic Diseases, 80 (5) annrheumdis-2020-219009, annrheumdis-2020. doi: 10.1136/annrheumdis-2020-219009 |
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2021 Journal Article CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetesNarsale, Aditi, Lam, Breanna, Moya, Rosa, Lu, TingTing, Mandelli, Alessandra, Gotuzzo, Irene, Pessina, Benedetta, Giamporcaro, Gianmaria, Geoffrey, Rhonda, Buchanan, Kerry, Harris, Mark, Bergot, Anne-Sophie, Thomas, Ranjeny, Hessner, Martin J., Battaglia, Manuela, Serti, Elisavet and Davies, Joanna D. (2021). CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. JCI Insight, 6 (2) e136114. doi: 10.1172/jci.insight.136114 |
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2021 Journal Article Rheumatoid arthritis is a preventable disease: 11 ways to reduce your patients’ riskKoller‐Smith, Louise, Mehdi, Ahmed M., March, Lyn, Tooth, Leigh, Mishra, Gita and Thomas, Ranjeny (2021). Rheumatoid arthritis is a preventable disease: 11 ways to reduce your patients’ risk. Internal Medicine Journal, 52 (5), 711-716. doi: 10.1111/imj.15537 |
