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Featured 2018 Journal Article Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapyZeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018). Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 (5), 1971-1984. doi: 10.1172/JCI96791 |
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Featured 2018 Journal Article A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetesMehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018). A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 (5) e98212. doi: 10.1172/jci.insight.98212 |
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2017 Journal Article Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritisScally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017). Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 (11), 1915-1923. doi: 10.1136/annrheumdis-2017-211300 |
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Featured 2015 Journal Article Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patientsBenham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015). Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 (290) 290ra87, 290ra87.1-290ra87.11. doi: 10.1126/scitranslmed.aaa9301 |
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2015 Journal Article High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG miceBaillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015). High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 (6), 1535-1547. doi: 10.1002/art.39041 |
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Featured 2014 Journal Article ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG MiceRehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014). ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 (10), 2780-2792. doi: 10.1002/art.38773 |
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Featured 2014 Journal Article Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG miceBenham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638 |
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Featured 2013 Journal Article A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritisScally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013). A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 (12), 2569-2582. doi: 10.1084/jem.20131241 |
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2012 Journal Article β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG miceRuutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 (7), 2211-2222. doi: 10.1002/art.34423 |
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Featured 2009 Journal Article Antigen-specific suppression of inflammatory arthritis using liposomesCapini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009). Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 (6), 3556-3565. doi: 10.4049/jimmunol.0802972 |
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2025 Journal Article Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful diseaseDeane, Kevin D, Holers, V Michael, Emery, Paul, Mankia, Kulveer, El Gabalawy, Hani, Sparks, Jeffrey A, Costenbader, Karen H, Schett, Georg, van der Helm-van Mil, Annette, van Schaardenburg, Dirkjan, Thomas, Ranjeny and Cope, Andrew P (2025). Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful disease. Annals of the Rheumatic Diseases, 84 (1) 224211, 14-28. doi: 10.1136/ard-2023-224211 |
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2024 Conference Publication Self or Bacteria-reactive Th17 Expand from Conventional and Regulatory T Cells in Parabacteroides Goldsteinii Gnotobiotic Arthritic SKG Mice, in Context of Interferon-driven Synovial Inflammatory Macrophages and Reduced Bacterial Immune RegulationCai, Benjamin, Tuong, Zewen Kelvin, Morrison, Mark, Bergot, Anne-Sophie and Thomas, Ranjeny (2024). Self or Bacteria-reactive Th17 Expand from Conventional and Regulatory T Cells in Parabacteroides Goldsteinii Gnotobiotic Arthritic SKG Mice, in Context of Interferon-driven Synovial Inflammatory Macrophages and Reduced Bacterial Immune Regulation. ACR Convergence 2024, Washington, DC United States, 15–19 November 2024. Hoboken, NJ United States: John Wiley & Sons. |
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2024 Conference Publication Depletion of citrullinated vimentin-reactive follicular helper T cells with treatment-induced remission of recent-onset rheumatoid arthritis when compared to non-remission at 6 monthsHee, Jia Yi, Nel, Hendrik, Abraham, Yann, Chakradeo, Katrina, Roch, Michelle, Lynch, Tom, March, Lyn, Wechalekar, Mihir, Keen, Helen and Thomas, Ranjeny (2024). Depletion of citrullinated vimentin-reactive follicular helper T cells with treatment-induced remission of recent-onset rheumatoid arthritis when compared to non-remission at 6 months. ACR Convergence 2024, Washington, DC, United States, 14 - 19 November 2024. Hoboken, NJ, United States: John Wiley & Sons. |
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2024 Conference Publication Citrullinated vimentin-reactive immune-regulatory CD4+CD39+TIGIThi T cells expand during drug free remission in HLA-DR shared-epitope plus ACPA plus rheumatoid arthritisAnderson, Amy, Lemos, Henrique de Paula, Nel, Hendrik, Santiago, Sofia Sorbet, Rayner, Fiona, Degnan, Abbie, Wilson, Imogen, Diboll, Julie, Sim, Jasmine, Melville, Andrew, Siebert, Stefan, McInnes, Iain, Goodyear, Carl, Hilkens, Catharien, Filer, Andrew, Raza, Karim, Buckley, Christopher, Reid, Hugh, Baker, Kenneth, Pratt, Arthur, Rossjohn, Jamie, Thomas, Ranjeny and Isaacs, John (2024). Citrullinated vimentin-reactive immune-regulatory CD4+CD39+TIGIThi T cells expand during drug free remission in HLA-DR shared-epitope plus ACPA plus rheumatoid arthritis. ACR Convergence 2024, Washington, DC, United States, 14 - 19 November 2024. Hoboken, NJ, United States: John Wiley & Sons. |
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2024 Conference Publication Unveiling the uterine-joint axis: dysbiosis and subclinical uterine inflammation in female axial spondyloarthritis pathogenesisMauro, Daniele, Vecellio, Matteo, Bergot, Anne-Sophie, Schmid, Eva, Forte, Giulio, Stingo, Alessia, Salzillo, Alessia, Pastore, Aldo, Aretini, Paolo, Di Lorenzo, Francesca, Ciancio, Antonio, Pantano, Ilenia, Saccone, Gabriele, Zullo, Fulvio, Montecucco, Carlo Maurizio, Rizzo, Aroldo, Schett, Georg, Thomas, Ranjeny, Zaiss, Mario and Ciccia, Francesco (2024). Unveiling the uterine-joint axis: dysbiosis and subclinical uterine inflammation in female axial spondyloarthritis pathogenesis. ACR Convergence: where rheumatology meets, Washington, DC, United States, 14 - 19 November 2024. Hoboken, NJ, United States: John Wiley & Sons. |
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2024 Journal Article Exploring the association between circulating endothelial protein C receptor and disease activity of rheumatoid arthritis in a pilot studyXue, Meilang, Lin, Haiyan, Lynch, Tom, Bereza-Malcolm, Lara, Sinnathurai, Premarani, Thomas, Ranjeny, Keen, Helen, Hill, Catherine, Lester, Susan, Wechalekar, Mihir and March, Lyn (2024). Exploring the association between circulating endothelial protein C receptor and disease activity of rheumatoid arthritis in a pilot study. Rheumatology Advances in Practice, 8 (3) rkae096, rkae096. doi: 10.1093/rap/rkae096 |
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2024 Journal Article A novel method to monitor rheumatoid arthritis prevalence using hospital and medication databasesKoller-Smith, Louise, Mehdi, Ahmed, March, Lyn, Tooth, Leigh, Mishra, Gita D. and Thomas, Ranjeny (2024). A novel method to monitor rheumatoid arthritis prevalence using hospital and medication databases. Arthritis Research and Therapy, 26 (1) 133, 133. doi: 10.1186/s13075-024-03366-x |
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2024 Conference Publication POS0303 Crossing the barriers: dysbiosis and subclinical uterine inflammation in the pathogenesis of AxSpA in females. Another break in the wall?Mauro, D., Vecellio, M., Schmid, E., Bergot, A. S., Forte, G., Stingo, A., Salzillo, A., Pastore, A., Aretini, P., Ciancio, A., Pantano, I., Saccone, G., Zullo, F., Montecucco, C., Rizzo, A., Schett, G., Thomas, R., Zaiss, M. M. and Ciccia, F. (2024). POS0303 Crossing the barriers: dysbiosis and subclinical uterine inflammation in the pathogenesis of AxSpA in females. Another break in the wall?. EULAR 2024 European Congress of Rheumatology, Vienna, Austria, 12 - 15 June 2024. New York, NY, United States: Oxford University Press. doi: 10.1136/annrheumdis-2024-eular.4993 |
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2024 Conference Publication Type 3 cytokine blockade in translocation of instestinal bacteria in spondyloarthropathyCai, B., Giri, R., Benham, H., Rehaume, L., Strutton, G., Bergot, A. S. and Thomas, R. (2024). Type 3 cytokine blockade in translocation of instestinal bacteria in spondyloarthropathy. EULAR 2024 European Congress of Rheumatology, Vienna, Austria, 12-15 June 2024. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2024-eular.2408 |
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2024 Conference Publication POS0313 Intestinal neuroinflammation in spa is correlated with dysbiosisForte, G., Mauro, D., Bergot, A. S., Cameron, A., Ciancio, A., Scalise, G., Salzillo, A., Pantano, I., Panarese, I., Vespere, G., De Luca, L., Desena, G., Napolitano, V., Franco, R., Provitera, V., Thomas, R. and Ciccia, F. (2024). POS0313 Intestinal neuroinflammation in spa is correlated with dysbiosis. EULAR 2024 European Congress of Rheumatology, Vienna, Austria, 12 - 15 June 2024. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2024-eular.5422 |
