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Featured 2018 Journal Article Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapyZeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018). Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 (5), 1971-1984. doi: 10.1172/JCI96791 |
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Featured 2018 Journal Article A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetesMehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018). A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 (5) e98212. doi: 10.1172/jci.insight.98212 |
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Featured 2017 Journal Article Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritisScally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017). Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 (11), 1915-1923. doi: 10.1136/annrheumdis-2017-211300 |
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Featured 2015 Journal Article Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patientsBenham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015). Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 (290) 290ra87, 290ra87.1-290ra87.11. doi: 10.1126/scitranslmed.aaa9301 |
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Featured 2015 Journal Article High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG miceBaillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015). High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 (6), 1535-1547. doi: 10.1002/art.39041 |
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Featured 2014 Journal Article ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG MiceRehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014). ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 (10), 2780-2792. doi: 10.1002/art.38773 |
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Featured 2014 Journal Article Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG miceBenham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638 |
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Featured 2013 Journal Article A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritisScally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013). A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 (12), 2569-2582. doi: 10.1084/jem.20131241 |
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Featured 2012 Journal Article β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG miceRuutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 (7), 2211-2222. doi: 10.1002/art.34423 |
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Featured 2009 Journal Article Antigen-specific suppression of inflammatory arthritis using liposomesCapini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009). Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 (6), 3556-3565. doi: 10.4049/jimmunol.0802972 |
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2025 Journal Article The role of the gut and intestinal dysbiosis in the pathogenesis of spondyloarthritisMauro, Daniele, Cai, Benjamin, Ciancio, Antonio, Forte, Giulio, Gandolfo, Saviana, Thomas, Ranjeny, Bergot, Anne-Sophie and Ciccia, Francesco (2025). The role of the gut and intestinal dysbiosis in the pathogenesis of spondyloarthritis. Joint Bone Spine, 92 (6) 105923, 1-6. doi: 10.1016/j.jbspin.2025.105923 |
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2025 Journal Article AI automated radiographic scoring in rheumatoid arthritis: Shedding light on barriers to implementation through comprehensive evaluationBird, Alix, Oakden-Rayner, Lauren, Chakradeo, Katrina, Thomas, Ranjeny, Gupta, Drishti, Jain, Suyash, Jacob, Rohan, Ray, Shonket, Wechalekar, Mihir D, Proudman, Susanna and Palmer, Lyle J. (2025). AI automated radiographic scoring in rheumatoid arthritis: Shedding light on barriers to implementation through comprehensive evaluation. Seminars in Arthritis and Rheumatism, 74 152761, 152761-74. doi: 10.1016/j.semarthrit.2025.152761 |
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2025 Journal Article Pathogenic OTUD3 mutations predispose to ulcerative colitis due to barrier dysfunctionGiri, Rabina, Lee, Minyi, Magor, Graham, Bergot, Anne-Sophie, He, Yaowu, Kryza, Thomas, Khan, Tashbib, Schreiber, Veronika, Gordon, Robert J., Zagani, Rachid, Hasnain, Sumaira Z., Lourie, Rohan, Ewing, Adam, Hooper, John D., Thomas, Ranjeny, Florin, Timothy H., Perkins, Andrew, Gala, Manish and Begun, Jakob (2025). Pathogenic OTUD3 mutations predispose to ulcerative colitis due to barrier dysfunction. Cellular and Molecular Gastroenterology and Hepatology 101659, 101659. doi: 10.1016/j.jcmgh.2025.101659 |
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2025 Journal Article Resilience And Healthy Lifestyle for Rheumatoid Arthritis (The RA-HEAL trial): a randomised, parallel group, placebo-controlled clinical trial protocolPoulsen, Katherine A., Burton, Nicola W., Mayr, Hannah L., Chachay, Veronique S., Coombes, Jeff S., Gartner, Coral E., Sonigra, Amee, Christensen, Paul, Hansford, Karl A., Ang, Dianna J., Neri, Jessica, Mendis, Ramali, Lynch, Tom, Dines, Cheryl, Benham, Helen, Sweeney, Aoife, March, Lyn M., Khan, Asaduzzaman, Tuffaha, Haitham and Thomas, Ranjeny (2025). Resilience And Healthy Lifestyle for Rheumatoid Arthritis (The RA-HEAL trial): a randomised, parallel group, placebo-controlled clinical trial protocol. Trials, 26 (1) 376. doi: 10.1186/s13063-025-09063-7 |
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2025 Journal Article Pro-inflammatory macrophages transporting gut-derived bacterial DNA drive autoimmune arthritis in spondyloarthropathyCai, Benjamin, Giri, Rabina, Cameron, Amy J., Rahman, M. Arifur, Small, Annabelle, Altmann, Christopher, Lim, Yenkai, Rehaume, Linda M., Morrison, Mark, Wechalekar, Mihir D., Begun, Jakob, Bergot, Anne-Sophie and Thomas, Ranjeny (2025). Pro-inflammatory macrophages transporting gut-derived bacterial DNA drive autoimmune arthritis in spondyloarthropathy. JCI Insight, 10 (17) e188028. doi: 10.1172/jci.insight.188028 |
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2025 Journal Article Interaction between haploinsufficiency of PTPN2 and patient microbiome promotes autoimmune arthritis in miceSendo, Sho, Vela, Allison J., Ro, Myungja, Thiruppathy, Deepan, Wilkinson, Elizabeth L., Zhao, Zixuan, Hsieh, Wan-Chen, Yang, Shen, Coras, Roxana, Bergot, Anne-Sophie, Guma, Monica, Nguyen, Anders, McBride, David A., Devkota, Suzanne, Thomas, Ranjeny, Shah, Nisarg J., Svensson, Mattias N.D., Zengler, Karsten, Stanford, Stephanie M. and Bottini, Nunzio (2025). Interaction between haploinsufficiency of PTPN2 and patient microbiome promotes autoimmune arthritis in mice. Journal of Autoimmunity, 156 103452, 103452-156. doi: 10.1016/j.jaut.2025.103452 |
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2025 Journal Article PD‐1 expressing islet‐specific CD4+ T cells promote bystander tolerance and prevent autoimmunityLoaiza Naranjo, Jeniffer D., Zhang, Vivian, Ravichandran, Rathna, Bergot, Anne‐Sophie, Thomas, Ranjeny and Hamilton‐Williams, Emma E. (2025). PD‐1 expressing islet‐specific CD4+ T cells promote bystander tolerance and prevent autoimmunity. Immunology and Cell Biology, 103 (7) imcb., 738-751. doi: 10.1111/imcb.70044 |
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2025 Journal Article Interleukin-6 in synovial fluid drives the conversion of DC2s to DC3s in inflammatory arthritisDecker, Annika H., van den Hoogen, Lucas L., van Oorschot, Tom, Sanchez-Rocha, Liliana, Boks, Martine A., Bakdash, Ghaith, Thomas, Ranjeny, Popa, Calin D., Verdoes, Martijn, Thurlings, Rogier M., Becker, Anouk M.D. and de Vries, I. Jolanda M. (2025). Interleukin-6 in synovial fluid drives the conversion of DC2s to DC3s in inflammatory arthritis. iScience, 28 (7) 112957, 112957-7. doi: 10.1016/j.isci.2025.112957 |
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2025 Journal Article Th Cell Phenotypes and Their Correlations with Disease Activity in Patients with Rheumatoid ArthritisXue, Meilang, Lin, Haiyan, Lynch, Tom, Chand, Vibhasha, Sinnathurai, Premarani, Thomas, Ranjeny, Keen, Helen, Hill, Catherine, Lester, Susan, Wechalekar, Mihir, Lassere, Marissa and March, Lyn (2025). Th Cell Phenotypes and Their Correlations with Disease Activity in Patients with Rheumatoid Arthritis. Journal of Clinical Medicine, 14 (12) 4220, 4220-12. doi: 10.3390/jcm14124220 |
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2025 Journal Article JAK inhibition and axial spondyloarthritis: new steps on the path to understanding pathophysiologyCiccia, Francesco, Mcgonagle, Dennis, Thomas, Ranjeny, Marzo-Ortega, Helena, Martin, David A., Yndestad, Arne and Volkov, Mikhail (2025). JAK inhibition and axial spondyloarthritis: new steps on the path to understanding pathophysiology. Frontiers in Immunology, 16 1488357, 1488357. doi: 10.3389/fimmu.2025.1488357 |
