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2020

Journal Article

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

Moen, Gunn-Helen, Beaumont, Robin N., Grarup, Niels, Sommer, Christine, Shields, Beverley M., Lawlor, Deborah A., Freathy, Rachel M., Evans, David M. and Warrington, Nicole M. (2020). Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight. International Journal of Epidemiology, 50 (1), 179-189. doi: 10.1093/ije/dyaa256

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

2020

Journal Article

A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)

D'Urso, Shannon, Wang, Geng, Hwang, Liang-Dar, Moen, Gunn-Helen, Warrington, Nicole M. and Evans, David M. (2020). A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD). Journal of Developmental Origins of Health and Disease, 12 (5) PII S2040174420001105, 1-6. doi: 10.1017/S2040174420001105

A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)

2020

Journal Article

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs

Hwang, Liang-Dar, Tubbs, Justin D., Luong, Justin, Lundberg, Mischa, Moen, Gunn-Helen, Wang, Geng, Warrington, Nicole M., Sham, Pak C., Cuellar-Partida, Gabriel and Evans, David M. (2020). Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs. PLoS Genetics, 16 (10) e1009154, e1009154. doi: 10.1371/journal.pgen.1009154

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs

2020

Journal Article

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

Moen, Gunn-Helen, Brumpton, Ben, Willer, Cristen, Åsvold, Bjørn Olav, Birkeland, Kåre I., Wang, Geng, Neale, Michael C., Freathy, Rachel M., Smith, George Davey, Lawlor, Deborah A., Kirkpatrick, Robert M., Warrington, Nicole M. and Evans, David M. (2020). Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort. Nature Communications, 11 (1) 5404, 5404. doi: 10.1038/s41467-020-19257-z

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

2020

Journal Article

Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida, Gabriel, Tung, Joyce Y., Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A., Barroso, Inês, Beckmann, Jacques S., Boks, Marco P., Boomsma, Dorret I., Boyd, Heather A., Breteler, Monique M. B., Campbell, Harry, Chasman, Daniel I., Cherkas, Lynn F., Davies, Gail, de Geus, Eco J. C., Deary, Ian J., Deloukas, Panos, Dick, Danielle M., Duffy, David L., Eriksson, Johan G., Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D., Han, Jiali ... Medland, Sarah E. (2020). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5 (1), 59-70. doi: 10.1038/s41562-020-00956-y

Genome-wide association study identifies 48 common genetic variants associated with handedness

2020

Journal Article

The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization study

Zheng, Jie, Brion, Marie-Jo, Kemp, John P., Warrington, Nicole M., Borges, Maria-Carolina, Hemani, Gibran, Richardson, Tom G., Rasheed, Humaira, Qiao, Zhen, Haycock, Philip, Ala-Korpela, Mika, Davey Smith, George, Tobias, Jon H. and Evans, David M. (2020). The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization study. Journal of Bone and Mineral Research, 35 (7) jbmr.3989, 1224-1235. doi: 10.1002/jbmr.3989

The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization study

2020

Journal Article

Integrating family-based and Mendelian randomization designs

Hwang, Liang-Dar, Davies, Neil M., Warrington, Nicole M. and Evans, David M. (2020). Integrating family-based and Mendelian randomization designs. Cold Spring Harbor Perspectives in Medicine, 11 (3) a039503, 1-15. doi: 10.1101/cshperspect.a039503

Integrating family-based and Mendelian randomization designs

2019

Journal Article

Introducing M-GCTA a software package to estimate maternal (or paternal) genetic effects on offspring phenotypes

Qiao, Zhen, Zheng, Jie, Helgeland, Øyvind, Vaudel, Marc, Johansson, Stefan, Njølstad, Pål R., Smith, George Davey, Warrington, Nicole M. and Evans, David M. (2019). Introducing M-GCTA a software package to estimate maternal (or paternal) genetic effects on offspring phenotypes. Behavior Genetics, 50 (1), 51-66. doi: 10.1007/s10519-019-09969-4

Introducing M-GCTA a software package to estimate maternal (or paternal) genetic effects on offspring phenotypes

2019

Journal Article

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Couto Alves, Alexessander, De Silva, N. Maneka G., Karhunen, Ville, Sovio, Ulla, Das, Shikta, Taal, H. Rob, Warrington, Nicole M., Lewin, Alexandra M., Kaakinen, Marika, Cousminer, Diana L., Thiering, Elisabeth, Timpson, Nicholas J., Bond, Tom A., Lowry, Estelle, Brown, Christopher D., Estivill, Xavier, Lindi, Virpi, Bradfield, Jonathan P., Geller, Frank, Speed, Doug, Coin, Lachlan J. M., Loh, Marie, Barton, Sheila J., Beilin, Lawrence J., Bisgaard, Hans, Bønnelykke, Klaus, Alili, Rohia, Hatoum, Ida J., Schramm, Katharina ... Early Growth Genetics (EGG) Consortium (2019). GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances, 5 (9) eaaw3095, eaaw3095. doi: 10.1126/sciadv.aaw3095

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

2019

Journal Article

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

Hwang, Liang-Dar, Lawlor, Deborah A., Freathy, Rachel M., Evans, David M. and Warrington, Nicole M. (2019). Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight. International Journal of Epidemiology, 48 (5), 1457-1467. doi: 10.1093/ije/dyz160

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

2019

Journal Article

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Warrington, Nicole M., Beaumont, Robin N., Horikoshi, Momoko, Day, Felix R., Helgeland, Øyvind, Laurin, Charles, Bacelis, Jonas, Peng, Shouneng, Hao, Ke, Feenstra, Bjarke, Wood, Andrew R., Mahajan, Anubha, Tyrrell, Jessica, Robertson, Neil R., Rayner, N. William, Qiao, Zhen, Moen, Gunn-Helen, Vaudel, Marc, Marsit, Carmen J., Chen, Jia, Nodzenski, Michael, Schnurr, Theresia M., Zafarmand, Mohammad H., Bradfield, Jonathan P., Grarup, Niels, Kooijman, Marjolein N., Li-Gao, Ruifang, Geller, Frank, Paternoster, Lavinia ... Freathy, Rachel M. (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature Genetics, 51 (5), 804-814. doi: 10.1038/s41588-019-0403-1

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

2019

Journal Article

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization

Evans, David M., Moen, Gunn-Helen, Hwang, Liang-Dar, Lawlor, Debbie A. and Warrington, Nicole M. (2019). Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. International Journal of Epidemiology, 48 (3), 861-875. doi: 10.1093/ije/dyz019

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization

2019

Journal Article

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

Hartwig, Fernando Pires, Davies, Neil Martin, Horta, Bernardo Lessa, Ahluwalia, Tarunveer S., Bisgaard, Hans, Bønnelykke, Klaus, Caspi, Avshalom, Moffitt, Terrie E., Poulton, Richie, Sajjad, Ayesha, Tiemeier, Henning W., Dalmau-Bueno, Albert, Guxens, Mònica, Bustamante, Mariona, Santa-Marina, Loreto, Parker, Nadine, Paus, Tomáš, Pausova, Zdenka, Lauritzen, Lotte, Schnurr, Theresia M., Michaelsen, Kim F., Hansen, Torben, Oddy, Wendy, Pennell, Craig E., Warrington, Nicole M., Davey Smith, George and Victora, Cesar Gomes (2019). Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis. International Journal of Epidemiology, 48 (1), 45-57. doi: 10.1093/ije/dyy273

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

2019

Journal Article

Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies

Moen, Gunn-Helen, Hemani, Gibran, Warrington, Nicole M. and Evans, David M. (2019). Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies. Behavior Genetics, 49 (3), 327-339. doi: 10.1007/s10519-018-9944-9

Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies

2018

Journal Article

Antibody response to common human viruses is shaped by genetic factors

Hayward, Tanisha A., Zhu, Gu, Warrington, Nicole M., Wong, Yide, Ryan, Rachael Y.M., Murray, Abella M., Haigh, Oscar, Martin, Nicholas G., Miles, John J. and Evans, David M. (2018). Antibody response to common human viruses is shaped by genetic factors. Journal of Allergy and Clinical Immunology, 143 (4), 1640-1643. doi: 10.1016/j.jaci.2018.11.039

Antibody response to common human viruses is shaped by genetic factors

2018

Journal Article

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

Warrington, Nicole M., Shevroja, Enisa, Hemani, Gibran, Hysi, Pirro G., Jiang, Yunxuan, Auton, Adam, Boer, Cindy G., Mangino, Massimo, Wang, Carol A., Kemp, John P., McMahon, George, Medina-Gomez, Carolina, Hickey, Martha, Trajanoska, Katerina, Wolke, Dieter, Ikram, Arfan M., 23 and Me Research Team, Montgomery, Grant W., Felix, Janine F., Wright, Margaret J., Mackey, David A., Jaddoe, Vincent W., Martin, Nicholas G., Tung, Joyce Y., Davey Smith, George, Pennell, Craig E., Spector, Tim D., van Meurs, Joyce, Rivadeneira, Fernando ... Evans, David M. (2018). Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero. Human Molecular Genetics, 27 (11), 2025-2038. doi: 10.1093/hmg/ddy121

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

2018

Journal Article

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Beaumont, Robin N., Warrington, Nicole M., Cavadino, Alana, Tyrrell, Jessica, Nodzenski, Michael, Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Richmond, Rebecca C., Paternoster, Lavinia, Bradfield, Jonathan P., Kreiner-Møller, Eskil, Huikari, Ville, Metrustry, Sarah, Lunetta, Kathryn L., Painter, Jodie N., Hottenga, Jouke-Jan, Allard, Catherine, Barton, Sheila J., Espinosa, Ana, Marsh, Julie A., Potter, Catherine, Zhang, Ge, Ang, Wei, Berry, Diane J., Bouchard, Luigi, Das, Shikta, Early Growth Genetics (EGG) Consortium, Hakonarson, Hakon ... Freathy, Rachel M. (2018). Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics, 27 (4) ddx429, 742-756. doi: 10.1093/hmg/ddx429

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

2018

Journal Article

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

Warrington, Nicole M., Freathy, Rachel M., Neale, Michael C. and Evans, David M. (2018). Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank. International Journal of Epidemiology, 47 (4), 1229-1241. doi: 10.1093/ije/dyy015

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

2017

Journal Article

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T., Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J. ... Lawlor, D. A. (2017). Maternal and fetal genetic contribution to gestational weight gain. International Journal of Obesity (2005), 42 (4), 775-784. doi: 10.1038/ijo.2017.248

Maternal and fetal genetic contribution to gestational weight gain

2017

Journal Article

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Kemp, John P., Morris, John A., Medina-Gomez, Carolina, Forgetta, Vincenzo, Warrington, Nicole M., Youlten, Scott E., Zheng, Jie, Gregson, Celia L., Grundberg, Elin, Trajanoska, Katerina, Logan, John G., Pollard, Andrea S., Sparkes, Penny C., Ghirardello, Elena J., Allen, Rebecca, Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Adoum, Anne-Tounsia, Curry, Katharine F., White, Jacqueline K., Kussy, Fiona, Greenlaw, Keelin M., Xu, Changjiang, Harvey, Nicholas C., Cooper, Cyrus, Adams, David J., Greenwood, Celia M. T., Maurano, Matthew T. ... Evans, David M. (2017). Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics, 49 (10), 1468-1475. doi: 10.1038/ng.3949

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis