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2024

Journal Article

The Prospective Association between Early Life Growth and Breast Density in Young Adult Women

Lloyd, Rachel, Pirikahu, Sarah, Walter, Jane, Cadby, Gemma, Warrington, Nicole, Perera, Dilukshi, Hickey, Martha, Saunders, Christobel, Hackmann, Michael, Sampson, David D., Shepherd, John, Lilge, Lothar and Stone, Jennifer (2024). The Prospective Association between Early Life Growth and Breast Density in Young Adult Women. Cancers, 16 (13) 2418, 2418. doi: 10.3390/cancers16132418

The Prospective Association between Early Life Growth and Breast Density in Young Adult Women

2024

Journal Article

A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans

Moksnes, Marta R., Hansen, Ailin F., Wolford, Brooke N., Thomas, Laurent F., Rasheed, Humaira, Simić, Anica, Bhatta, Laxmi, Brantsæter, Anne Lise, Surakka, Ida, Zhou, Wei, Magnus, Per, Njølstad, Pål R., Andreassen, Ole A., Syversen, Tore, Zheng, Jie, Fritsche, Lars G., Evans, David M., Warrington, Nicole M., Nøst, Therese H., Åsvold, Bjørn Olav, Flaten, Trond Peder, Willer, Cristen J., Hveem, Kristian and Brumpton, Ben M. (2024). A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans. Communications Biology, 7 (1) 432, 432. doi: 10.1038/s42003-024-06101-z

A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans

2024

Journal Article

Meta-regression of genome-wide association studies to estimate age-varying genetic effects

Pagoni, Panagiota, Higgins, Julian P. T., Lawlor, Deborah A., Stergiakouli, Evie, Warrington, Nicole M., Morris, Tim T. and Tilling, Kate (2024). Meta-regression of genome-wide association studies to estimate age-varying genetic effects. European Journal of Epidemiology, 39 (3), 257-270. doi: 10.1007/s10654-023-01086-1

Meta-regression of genome-wide association studies to estimate age-varying genetic effects

2024

Journal Article

Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study

Thompson, W. D., Reynolds, R. M., Beaumont, R. N., Warrington, N. M., Tyrrell, J., Wood, A. R., Evans, D. M., McDonald, T. J., Hattersley, A. H., Freathy, R. M., Lawlor, D. A. and Borges, M. C. (2024). Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study. BMC Pregnancy and Childbirth, 24 (1) 65, 1-11. doi: 10.1186/s12884-024-06250-3

Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study

2024

Conference Publication

Examining the association between fetal HLA-C and maternal KIR haplotypes and birthweight in the UK biobank

Decina, Caitlin, Warrington, Nicole, Beaumont, Robin, Freathy, Rachel and Evans, David (2024). Examining the association between fetal HLA-C and maternal KIR haplotypes and birthweight in the UK biobank. 56th Annual Conference of the European Society of Human Genetics (ESHG), Glasgow, Scotland, 10-13 June 2023. London, United Kingdom: Nature Publishing Group.

Examining the association between fetal HLA-C and maternal KIR haplotypes and birthweight in the UK biobank

2023

Journal Article

Partitioning genetic effects on birthweight at classical human leukocyte antigen loci into maternal and fetal components, using structural equation modelling

Wang, Geng, Warrington, Nicole M. and Evans, David M. (2023). Partitioning genetic effects on birthweight at classical human leukocyte antigen loci into maternal and fetal components, using structural equation modelling. International Journal of Epidemiology, 53 (1) dyad142, 1-9. doi: 10.1093/ije/dyad142

Partitioning genetic effects on birthweight at classical human leukocyte antigen loci into maternal and fetal components, using structural equation modelling

2023

Journal Article

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study

Decina, Caitlin S., Hopkins, Rhian, Bowden, Jack, Shields, Beverly M., Lawlor, Deborah A., Warrington, Nicole M., Evans, David M., Freathy, Rachel M. and Beaumont, Robin N. (2023). Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study. International Journal of Epidemiology, 52 (1), 178-189. doi: 10.1093/ije/dyac186

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study

2023

Journal Article

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

Zhao, Jian, Stewart, Isobel D., Baird, Denis, Mason, Dan, Wright, John, Zheng, Jie, Gaunt, Tom R., Evans, David M., Freathy, Rachel M., Langenberg, Claudia, Warrington, Nicole M., Lawlor, Deborah A. and Borges, Maria Carolina (2023). Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study. eBioMedicine, 88 104441, 1-14. doi: 10.1016/j.ebiom.2023.104441

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

2023

Journal Article

Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review

Power, Grace M., Sanderson, Eleanor, Pagoni, Panagiota, Fraser, Abigail, Morris, Tim, Prince, Claire, Frayling, Timothy M., Heron, Jon, Richardson, Tom G., Richmond, Rebecca, Tyrrell, Jessica, Warrington, Nicole, Davey Smith, George, Howe, Laura D. and Tilling, Kate M. (2023). Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review. European Journal of Epidemiology, 39 (5), 501-520. doi: 10.1007/s10654-023-01032-1

Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review

2022

Journal Article

Using genomic structural equation modeling to partition the genetic covariance between birthweight and cardiometabolic risk factors into maternal and offspring components in the Norwegian HUNT study

Moen, Gunn-Helen, Nivard, Michel, Bhatta, Laxmi, Warrington, Nicole M., Willer, Cristen, Åsvold, Bjørn Olav, Brumpton, Ben and Evans, David M. (2022). Using genomic structural equation modeling to partition the genetic covariance between birthweight and cardiometabolic risk factors into maternal and offspring components in the Norwegian HUNT study. Behavior Genetics, 53 (1), 1-13. doi: 10.1007/s10519-022-10116-9

Using genomic structural equation modeling to partition the genetic covariance between birthweight and cardiometabolic risk factors into maternal and offspring components in the Norwegian HUNT study

2022

Journal Article

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

D’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

2022

Journal Article

Birth weight and cardiometabolic risk factors: a discordant twin study in the UK Biobank

Wang, Geng, Bond, Tom A., Warrington, Nicole M. and Evans, David M. (2022). Birth weight and cardiometabolic risk factors: a discordant twin study in the UK Biobank. Journal of Developmental Origins of Health and Disease, 14 (2) PII S2040174422000538, 1-7. doi: 10.1017/s2040174422000538

Birth weight and cardiometabolic risk factors: a discordant twin study in the UK Biobank

2022

Journal Article

Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

Brito Nunes, Caroline, Huang, Peiyuan, Wang, Geng, Lundberg, Mischa, D’Urso, Shannon, Wootton, Robyn E., Borges, Maria Carolina, Lawlor, Deborah A., Warrington, Nicole M., Evans, David M., Hwang, Liang-Dar and Moen, Gunn-Helen (2022). Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth. International Journal of Epidemiology, 52 (1), 1-13. doi: 10.1093/ije/dyac121

Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

2022

Book Chapter

Integrating family-based and Mendelian randomization designs

Hwang, Liang-Dar, Davies, Neil M., Warrington, Nicole M. and Evans, David M. (2022). Integrating family-based and Mendelian randomization designs. Combining human genetics and causal inference to understand human disease and development. (pp. 137-150) edited by George Davey Smith, Rebecca Richmond and Jean-Baptiste Pingault. Cold Spring Harbor, NY, United States: Cold Spring Harbor Laboratory Press.

Integrating family-based and Mendelian randomization designs

2022

Journal Article

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

Wang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2022). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Hypertension, 79 (1), 170-177. doi: 10.1161/hypertensionaha.121.17701

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

2021

Journal Article

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

Thompson, William D., Beaumont, Robin N., Kuang, Alan, Warrington, Nicole M., Ji, Yingjie, Tyrrell, Jess, Wood, Andrew R., Scholtens, Denise, Knight, Bridget A., Evans, David M., Lowe, Bill L., Santorelli, Gillian, Azad, Raq, Mason, Dan, Hattersley, Andrew T., Frayling, Timothy M., Yaghootkar, Hanieh, Borges, Maria-Carolina, Lawlor, Deborah A. and Freathy, Rachel M. (2021). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight. Human Molecular Genetics, 31 (11), 1762-1775. doi: 10.1093/hmg/ddab356

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

2021

Conference Publication

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

Wang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Asvold, Bjorn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2021). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Behavior Genetics Association 51st Annual Meeting, Online (Zoom), 29 June 2021. New York, United States: Springer.

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

2021

Conference Publication

Methods for Enabling and Improving the Power of Mendelian Randomization Studies of Parental Environmental Exposures and Offspring Outcomes

Moen, Gunn-Helen, Bhatta, Laxmi, Asvold, Bjorn Olav, Brumpton, Ben, Warrington, Nicole M. and Evans, David M. (2021). Methods for Enabling and Improving the Power of Mendelian Randomization Studies of Parental Environmental Exposures and Offspring Outcomes. NEW YORK: SPRINGER.

Methods for Enabling and Improving the Power of Mendelian Randomization Studies of Parental Environmental Exposures and Offspring Outcomes

2021

Journal Article

Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile

Thompson, William D., Beaumont, Robin N., Kuang, Alan, Warrington, Nicole M., Ji, Yingjie, Tyrrell, Jessica, Wood, Andrew R., Scholtens, Denise M., Knight, Bridget A., Evans, David M., Lowe, William L., Santorelli, Gillian, Azad, Rafaq, Mason, Dan, Hattersley, Andrew T., Frayling, Timothy M., Yaghootkar, Hanieh, Borges, Maria Carolina, Lawlor, Deborah A. and Freathy, Rachel M. (2021). Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile. Diabetologia, 64 (12), 2790-2802. doi: 10.1007/s00125-021-05570-9

Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile

2021

Journal Article

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

Warrington, Nicole M., Hwang, Liang-Dar, Nivard, Michel G. and Evans, David M. (2021). Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data. Nature Communications, 12 (1) 5420, 1-12. doi: 10.1038/s41467-021-25723-z

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data