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2019

Journal Article

Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies

Moen, Gunn-Helen, Hemani, Gibran, Warrington, Nicole M. and Evans, David M. (2019). Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies. Behavior Genetics, 49 (3), 327-339. doi: 10.1007/s10519-018-9944-9

Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies

2019

Conference Publication

Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes

Evans, David, Warrington, Nicole, Partida, Gabriel Cuellar and Hwang, Daniel (2019). Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes. 49th Annual Meeting of the Behavior Genetics Association (BGA), Stockholm, Sweden, 26-29 June, 2019. New York, NY, United States: Springer New York LLC. doi: 10.1007/s10519-019-09973-8

Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes

2018

Journal Article

Antibody response to common human viruses is shaped by genetic factors

Hayward, Tanisha A., Zhu, Gu, Warrington, Nicole M., Wong, Yide, Ryan, Rachael Y.M., Murray, Abella M., Haigh, Oscar, Martin, Nicholas G., Miles, John J. and Evans, David M. (2018). Antibody response to common human viruses is shaped by genetic factors. Journal of Allergy and Clinical Immunology, 143 (4), 1640-1643. doi: 10.1016/j.jaci.2018.11.039

Antibody response to common human viruses is shaped by genetic factors

2018

Journal Article

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

Warrington, Nicole M., Shevroja, Enisa, Hemani, Gibran, Hysi, Pirro G., Jiang, Yunxuan, Auton, Adam, Boer, Cindy G., Mangino, Massimo, Wang, Carol A., Kemp, John P., McMahon, George, Medina-Gomez, Carolina, Hickey, Martha, Trajanoska, Katerina, Wolke, Dieter, Ikram, Arfan M., 23 and Me Research Team, Montgomery, Grant W., Felix, Janine F., Wright, Margaret J., Mackey, David A., Jaddoe, Vincent W., Martin, Nicholas G., Tung, Joyce Y., Davey Smith, George, Pennell, Craig E., Spector, Tim D., van Meurs, Joyce, Rivadeneira, Fernando ... Evans, David M. (2018). Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero. Human Molecular Genetics, 27 (11), 2025-2038. doi: 10.1093/hmg/ddy121

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

2018

Journal Article

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Beaumont, Robin N., Warrington, Nicole M., Cavadino, Alana, Tyrrell, Jessica, Nodzenski, Michael, Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Richmond, Rebecca C., Paternoster, Lavinia, Bradfield, Jonathan P., Kreiner-Møller, Eskil, Huikari, Ville, Metrustry, Sarah, Lunetta, Kathryn L., Painter, Jodie N., Hottenga, Jouke-Jan, Allard, Catherine, Barton, Sheila J., Espinosa, Ana, Marsh, Julie A., Potter, Catherine, Zhang, Ge, Ang, Wei, Berry, Diane J., Bouchard, Luigi, Das, Shikta, Early Growth Genetics (EGG) Consortium, Hakonarson, Hakon ... Freathy, Rachel M. (2018). Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics, 27 (4) ddx429, 742-756. doi: 10.1093/hmg/ddx429

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

2018

Journal Article

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

Warrington, Nicole M., Freathy, Rachel M., Neale, Michael C. and Evans, David M. (2018). Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank. International Journal of Epidemiology, 47 (4), 1229-1241. doi: 10.1093/ije/dyy015

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

2018

Conference Publication

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease

Beaumont, Robin N., Warrington, Nicole M., Horikoshi, Momoko, Day, Felix R., Ong, Ken K., McCarthy, Mark I., Perry, John R. B., Freathy, Rachel M. and Evans, David M. (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease. 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), San Diego, Ca, United States, 14-16 October 2018. Hoboken, NJ, United States: John Wiley & Sons.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease

2017

Journal Article

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T., Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J. ... Lawlor, D. A. (2017). Maternal and fetal genetic contribution to gestational weight gain. International Journal of Obesity (2005), 42 (4), 775-784. doi: 10.1038/ijo.2017.248

Maternal and fetal genetic contribution to gestational weight gain

2017

Journal Article

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Kemp, John P., Morris, John A., Medina-Gomez, Carolina, Forgetta, Vincenzo, Warrington, Nicole M., Youlten, Scott E., Zheng, Jie, Gregson, Celia L., Grundberg, Elin, Trajanoska, Katerina, Logan, John G., Pollard, Andrea S., Sparkes, Penny C., Ghirardello, Elena J., Allen, Rebecca, Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Adoum, Anne-Tounsia, Curry, Katharine F., White, Jacqueline K., Kussy, Fiona, Greenlaw, Keelin M., Xu, Changjiang, Harvey, Nicholas C., Cooper, Cyrus, Adams, David J., Greenwood, Celia M. T., Maurano, Matthew T. ... Evans, David M. (2017). Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics, 49 (10), 1468-1475. doi: 10.1038/ng.3949

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

2017

Journal Article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben ... Ohlsson, Claes (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 (1) 16015, 16015. doi: 10.1038/ncomms16015

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

2017

Other Outputs

Maternal and fetal genetic contribution to gestational weight gain

Warrington, Nicole M, Richmond, Rebecca, Fenstra, Bjarke, Myhre, Ronny, Gaillard, Romy, Paternoster, Lavinia, Wang, Carol A, Beaumont, Robin N, Das, Shikta, Murcia, Mario, Barton, Sheila J, Espinosa, Ana, Theiring, Elisabeth, Atalay, Mustafa, Pitkänen, Niina, Ntalla, Ioanna, Jonsson, Anna E, Freathy, Rachel, Karhunen, Ville, Tiesler, Carla MT, Allard, Catherine, Crawford, Andrew, Ring, Susan M, Melbye, Mads, Magnus, Per, Rivadeneira, Fernando, Skotte, Line, Hansen, Torben, Marsh, Julie ... consortium, Early Growth Genetics (2017). Maternal and fetal genetic contribution to gestational weight gain. doi: 10.1101/116434

Maternal and fetal genetic contribution to gestational weight gain

2017

Journal Article

Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them

Lawlor, Deborah, Richmond, Rebecca, Warrington, Nicole , McMahon, George, Davery Smith, George, Bowden, Jack and Evans, David M. (2017). Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. Wellcome Open Research, 2 (11) 11, 11. doi: 10.12688/wellcomeopenres.10567.1

Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them

2017

Journal Article

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

Kreiner, Eskil, Waage, Johannes, Standl, Marie, Brix, Susanne, Pers, Tune H., Couto Alves, Alexessander, Warrington, Nicole M., Tiesler, Carla M. T., Fuertes, Elaine, Franke, Lude, Hirschhorn, Joel N., James, Alan, Simpson, Angela, Tung, Joyce Y., Koppelman, Gerard H., Postma, Dirkje S., Pennell, Craig E., Jarvelin, Marjo-Riitta, Custovic, Adnan, Timpson, Nicholas, Ferreira, Manuel A., Strachan, David P., Henderson, John, Hinds, David, Bisgaard, Hans and Bønnelykke, Klaus (2017). Shared genetic variants suggest common pathways in allergy and autoimmune diseases. Allergy: European Journal of Allergy and Clinical Immunology, 140 (3), 771-781. doi: 10.1016/j.jaci.2016.10.055

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

2017

Journal Article

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

Zheng, Jie, Erzurumluoglu, A. Mesut, Elsworth, Benjamin L., Kemp, John P., Howe, Laurence, Haycock, Philip C., Hemani, Gibran, Tansey, Katherine, Laurin, Charles, St Pourcain, Beate, Warrington, Nicole M., Finucane, Hilary K., Price, Alkes L., Bulik-Sullivan, Brendan K., Anttila, Verneri, Paternoster, Lavinia, Gaunt, Tom R., Evans, David M. and Neale, Benjamin M. (2017). LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics, 33 (2), 272-279. doi: 10.1093/bioinformatics/btw613

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

2017

Conference Publication

Performing Mendelian randomization using structural equation models

Evans, David and Warrington, Nicole (2017). Performing Mendelian randomization using structural equation models. 47th Annual Meeting of the Behavior-Genetics-Association (BGA), Oslo Norway, 28 June - 1 July 2017. New York NY United States: Springer.

Performing Mendelian randomization using structural equation models

2016

Conference Publication

Genome-wide association study of 6,939 individuals identifies five novel loci and suggests that prenatal exposure to testosterone is not a major determinant of individual differences in 2D:4D finger ratio

Warrington, Nicole, Hemani, Gibran, Hysi, Pirro, Mangino, Massimo, McMahon, George, Hickey, Martha, Wolke, Dieter, Montgomery, Grant, Pennell, Craig, Spector, Tim, Martin, Nicholas, Medland, Sarah and Evans, David (2016). Genome-wide association study of 6,939 individuals identifies five novel loci and suggests that prenatal exposure to testosterone is not a major determinant of individual differences in 2D:4D finger ratio. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, Jun 20-23, 2016. NEW YORK: SPRINGER.

Genome-wide association study of 6,939 individuals identifies five novel loci and suggests that prenatal exposure to testosterone is not a major determinant of individual differences in 2D:4D finger ratio

2016

Conference Publication

Locus Discovery in Genome-wide Association Studies using Bivariate Analysis

Warrington, Nicole M. and Evans, David M. (2016). Locus Discovery in Genome-wide Association Studies using Bivariate Analysis. Annual Meeting of the International-Genetic-Epidemiology-Society, Toronto Canada, Oct 24-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Locus Discovery in Genome-wide Association Studies using Bivariate Analysis

2016

Conference Publication

LD hub and MR-base: online platforms for preforming LD score regression and Mendelian randomization analysis using GWAS summary data

Zheng, Jie, Haycock, Philip, Hemani, Gibran, Elsworth, Benjamin, Shihab, Hashem, Laurin, Charles, Erzurumluoglu, Mesut, Howe, Laurence, Wade, Kaitlin, Warrington, Nicole, Finucane, Hilary, Price, Alkes, Anttila, Verneri, Paternoster, Lavinia, Martin, Richard, Relton, Caroline, Gaunt, Tom, Smith, George Davey, Neale, Benjamin and Evans, David (2016). LD hub and MR-base: online platforms for preforming LD score regression and Mendelian randomization analysis using GWAS summary data. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, Jun 20-23, 2016. NEW YORK: SPRINGER.

LD hub and MR-base: online platforms for preforming LD score regression and Mendelian randomization analysis using GWAS summary data

2016

Journal Article

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, Momoko, Beaumont, Robin N., Day, Felix R., Warrington, Nicole M., Kooijman, Marjolein N., Fernandez-Tajes, Juan, Feenstra, Bjarke, van Zuydam, Natalie R., Gaulton, Kyle J., Grarup, Niels, Bradfield, Jonathan P., Strachan, David P., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Kreiner, Eskil, Rueedi, Rico, Lyytikainen, Leo-Pekka, Cousminer, Diana L., Wu, Ying, Thiering, Elisabeth, Wang, Carol A., Have, Christian T., Hottenga, Jouke-Jan, Vilor-Tejedor, Natalia, Joshi, Peter K., Boh, Eileen Tai Hui, Ntalla, Ioanna, Pitkanen, Niina, Mahajan, Anubha ... Freathy, Rachel M. (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538 (7624), 248-252. doi: 10.1038/nature19806

Genome-wide associations for birth weight and correlations with adult disease

2015

Other Outputs

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

Beaumont, Robin N, Warrington, Nicole M, Cavadino, Alana, Tyrrell, Jessica, Nodzenski, Michael, Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Richmond, Rebecca C., Paternoster, Lavinia, Bradfield, Jonathan P., Kreiner-Møller, Eskil, Huikari, Ville, Metrustry, Sarah, Lunetta, Kathryn L., Painter, Jodie N., Hottenga, Jouke-Jan, Allard, Catherine, Barton, Sheila J., Espinosa, Ana, Marsh, Julie A., Potter, Catherine, Zhang, Ge, Ang, Wei, Berry, Diane J., Bouchard, Luigi, Das, Shikta, Consortium, Early Growth Genetics, Hakonarson, Hakon ... Freathy, Rachel M. (2015). Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics. doi: 10.1101/034207

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics