Dr Dave Coman
Dr

Dave Coman

Email: 

Background

David is a Consultant Paediatrician, Metabolic Physician, Clinical Geneticist and clinician researcher. His area of expertise is the diagnosis and management of children with rare diseases. David is involved in multiple ongoing research projects aimed at novel disease discovery, improved diagnostic testing and treatments for children with inherited genetic disorders. He is director of a national clinic for Ataxia Telangiectasia brashat.org.au and has recently been awarded a $2.5 million NHMRC research grant for a phase 2/3 trial for treatment of this disorder.

Availability

Dr Dave Coman is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Developmental genetics (incl. sex determination) Gene expression (incl. microarray and other genome-wide approaches) Genetics Genomics Medical biochemistry - amino acids and metabolites Medical biochemistry and metabolomics Medical genetics (excl. cancer genetics) Metabolic medicine Paediatrics

Qualifications

  • Australian Health Practitioner Regulation Agency, Australian Health Practitioner Regulation Agency
  • Australian Medical Association, Australian Medical Association
  • Human Genetics Society of Australasia, Human Genetics Society of Australasia
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Society for the Study of Inborn Errors of Metabolism, Society for the Study of Inborn Errors of Metabolism

Research impacts

David has close relationships with research colleagues both in Australia and internationally. He has multiple ongoing research projects investigating novel disease identification, the genetics of paediatric speech disorders and the development of new therapeutic possibilities for children and adults with rare diseases.

Search Professor Dave Coman’s works on UQ eSpace

132 works between 2005 and 2025
All (132) Journal Article (115) Conference Publication (11) Book Chapter (6)

81 - 100 of 132 works

2016

Journal Article

<i>Arabidopsis</i> GERANYLGERANYL DIPHOSPHATE SYNTHASE 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids

Ruiz-Sola, M. Aguila, Coman, Diana, Beck, Gilles, Barja, M. Victoria, Colinas, Maite, Graf, Alexander, Welsch, Ralf, Ruetimann, Philipp, Buehlmann, Peter, Bigler, Laurent, Gruissem, Wilhelm, Rodriguez-Concepcion, Manuel and Vranova, Eva (2016). Arabidopsis GERANYLGERANYL DIPHOSPHATE SYNTHASE 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids. New Phytologist, 209 (1), 252-264. doi: 10.1111/nph.13580

<i>Arabidopsis</i> GERANYLGERANYL DIPHOSPHATE SYNTHASE 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids

2015

Journal Article

Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss

Gagliardi, Lucia, Nataren, Nathalie, Feng, Jinghua, Schreiber, Andreas W., Hahn, Christopher N., Conwell, Louise S., Coman, David and Scott, Hamish S. (2015). Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss. American Journal of Medical Genetics, Part A, 167 (8), 1872-1876. doi: 10.1002/ajmg.a.37075

Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss

2015

Journal Article

Septic arthritis of the temporomandibular joint in an infant

Chuk, Raymond, Arvier, John, Laing, Barbara and Coman, David (2015). Septic arthritis of the temporomandibular joint in an infant. Clinics and Practice, 5 (2) 736, 53-55. doi: 10.4081/cp.2015.736

Septic arthritis of the temporomandibular joint in an infant

2015

Conference Publication

Information processing in a child with Galactosaemia: an examination using behavioural and neuropysiological measures

Lewis, Fiona M., Knueppfer, Christina and Coman, David J. (2015). Information processing in a child with Galactosaemia: an examination using behavioural and neuropysiological measures. Federation of European Societies of Neuropsychology, Tampere, Finland, 9-11 September 2015. doi: 10.13140/RG.2.1.3218.9923

Information processing in a child with Galactosaemia: an examination using behavioural and neuropysiological measures

2015

Conference Publication

Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy

Sharwood, Erin F., McGill, Michael, Koorts, P. J., Coman, David and Conwell, Louise S. (2015). Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy. International Society of Paediatric and Adolescent Diabetes / Australasian Paediatric Endocrine Group Annual Scientific Meeting, Brisbane, Queensland, Australia, October 2015.

Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy

2015

Conference Publication

Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy

Sharwood, E. F., McGill, M., Koorts, P. J., Coman, D. and Conwell, L. S. (2015). Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy. Children's Health Queensland Research Conference, Brisbane, Queensland, Australia, December 2015.

Dizygotic twins with skeletal dysplasia and resistance to hormones signalling through G protein-coupled receptors and the Gsa/cAMP/PKA pathway - severe craniosynostosis and hypertrophic cardiomyopathy

2015

Book Chapter

Hepatic copper accumulation: a novel feature in transient infantile liver failure due to TRMU mutations?

Grover, Z., Lewindon, P., Clousten, A., Shaag, A., Elpeleg, O. and Coman, D. (2015). Hepatic copper accumulation: a novel feature in transient infantile liver failure due to TRMU mutations?. JIMD Reports, Volume 21. (pp. 109-113) edited by Johannes Zschocke, Matthias Baumgartner, Eva Morava, Marc Patterson, Shamima Rahman and Verena Peters. Berlin, Germany: Springer Berlin Heidelberg. doi: 10.1007/8904_2014_402

Hepatic copper accumulation: a novel feature in transient infantile liver failure due to TRMU mutations?

2014

Journal Article

Glucose transporter 1 deficiency syndrome and hemiplegic migraines as a dominant presenting clinical feature

Mohammad, Shekeeb S., Coman, David and Calvert, Sophie (2014). Glucose transporter 1 deficiency syndrome and hemiplegic migraines as a dominant presenting clinical feature. Journal of Paediatrics and Child Health, 50 (12), 1025-1026. doi: 10.1111/jpc.12613

Glucose transporter 1 deficiency syndrome and hemiplegic migraines as a dominant presenting clinical feature

2014

Journal Article

Pre-linguistic communication skill development in an infant with a diagnosis of galactosemia

Lewis, Fiona M., Coman, David J., Kilcoyne, Sarah, Murdoch, Bruce E. and Syrmis, Maryanne (2014). Pre-linguistic communication skill development in an infant with a diagnosis of galactosemia. Developmental Neurorehabilitation, 17 (5), 291-297. doi: 10.3109/17518423.2012.753479

Pre-linguistic communication skill development in an infant with a diagnosis of galactosemia

2014

Journal Article

Early markers of vulnerable language skill development in galactosaemia

Lewis, Fiona M., Coman, David J. and Syrnis, Maryanne (2014). Early markers of vulnerable language skill development in galactosaemia. Early Child Development and Care, 184 (12), 1787-1799. doi: 10.1080/03004430.2013.878712

Early markers of vulnerable language skill development in galactosaemia

2014

Journal Article

Age at assessment a critical factor when monitoring early communicative skills in children with galactosaemia

Lewis, Fiona M., DeJonge, Shannon M. and Coman, David J. (2014). Age at assessment a critical factor when monitoring early communicative skills in children with galactosaemia. Early Child Development and Care, 184 (11), 1636-1647. doi: 10.1080/03004430.2013.871275

Age at assessment a critical factor when monitoring early communicative skills in children with galactosaemia

2014

Journal Article

Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal syndrome

Wilson, Gabrielle R., Sunley, Jasmine, Smith, Katherine R., Pope, Kate, Bromhead, Catherine J., Fitzpatrick, Elizabeth, Di Rocco, Maja, Van Steensel, Maurice, Coman, David J., Leventer, Richard J., Delatycki, Martin B., Amor, David J., Bahlo, Melanie and Lockhart, Paul J. (2014). Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal syndrome. European Journal of Human Genetics, 22 (6), 741-747. doi: 10.1038/ejhg.2013.229

Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal syndrome

2014

Book Chapter

Impact of Impaired Maternal Vitamin A Status on Infant Eyes

Coman, David and Gole, Glen (2014). Impact of Impaired Maternal Vitamin A Status on Infant Eyes. Handbook of nutrition, diet and the eye. (pp. 377-382) edited by Victor R. Preedy. Burlington, MA United States: Elsevier Science. doi: 10.1016/B978-0-12-401717-7.00038-1

Impact of Impaired Maternal Vitamin A Status on Infant Eyes

2013

Journal Article

Charting a seven-year trajectory of language outcomes for a child with galactosemia

Lewis, Fiona M., Coman, David J., Syrmis, Maryann, Kilcoyne, Sarah and Murdoch, Bruce E. (2013). Charting a seven-year trajectory of language outcomes for a child with galactosemia. Journal of Developmental and Behavioral Pediatrics, 34 (6), 414-418. doi: 10.1097/DBP.0b013e31829a7be1

Charting a seven-year trajectory of language outcomes for a child with galactosemia

2013

Journal Article

Pediatric acute liver failure: etiology, outcomes, and the role of serial pediatric end-stage liver disease scores

Rajanayagam, Jeremy, Coman, David, Cartwright, David and Lewindon, Peter J. (2013). Pediatric acute liver failure: etiology, outcomes, and the role of serial pediatric end-stage liver disease scores. Pediatric Transplantation, 17 (4), 362-368. doi: 10.1111/petr.12083

Pediatric acute liver failure: etiology, outcomes, and the role of serial pediatric end-stage liver disease scores

2013

Book Chapter

Differential phonological awareness skills in children with classic galactosemia: a descriptive study of four cases

Lewis, Fiona M., Coman, David J., Syrmis, Maryanne, Kilcoyne, Sarah and Murdoch, Bruce E. (2013). Differential phonological awareness skills in children with classic galactosemia: a descriptive study of four cases. JIMD reports: case and research reports. (pp. 45-52) edited by Johannes Zschocke, K. Michael Gibson, Garry Brown, Eva Morava and Verena Peters. Dordrecht, Netherlands: Springer. doi: 10.1007/8904_2012_200

Differential phonological awareness skills in children with classic galactosemia: a descriptive study of four cases

2013

Journal Article

Fumarase deficiency in dichorionic diamniotic twins

Tregoning, S., Salter, W., Thorburn, D.R., Durkie, M., Panayi, M., Wu, J.Y., Easterbrook, A. and Coman, D.J. (2013). Fumarase deficiency in dichorionic diamniotic twins. Twin Research and Human Genetics, 16 (6), 1117-1120. doi: 10.1017/thg.2013.72

Fumarase deficiency in dichorionic diamniotic twins

2012

Journal Article

Impaired language abilities and pre-linguistic communication skills in a child with a diagnosis of galactosaemia

Lewis, Fiona M., Coman, David J., Syrmis, Maryanne, Kilcoyne, Sarah and Murdoch, Bruce E. (2012). Impaired language abilities and pre-linguistic communication skills in a child with a diagnosis of galactosaemia. Early Child Development and Care, 183 (12), 1747-1757. doi: 10.1080/03004430.2012.751101

Impaired language abilities and pre-linguistic communication skills in a child with a diagnosis of galactosaemia

2012

Journal Article

IgG N-glycans as potential biomarkers for determining galactose tolerance in Classical Galactosaemia

Coss, K.P., Byrne, J.C., Coman, D.J., Adamczyk, B., Abrahams, J.L., Saldova, R., Brown, A.Y., Walsh, O., Hendroff, U., Carolan, C., Rudd, P.M. and Treacy, E.P. (2012). IgG N-glycans as potential biomarkers for determining galactose tolerance in Classical Galactosaemia. Molecular Genetics and Metabolism, 105 (2), 1-9. doi: 10.1016/j.ymgme.2011.10.018

IgG N-glycans as potential biomarkers for determining galactose tolerance in Classical Galactosaemia

2012

Journal Article

Extended newborn screening: An update for the general paediatrician

Coman, David and Bhattacharya, Kaustuv (2012). Extended newborn screening: An update for the general paediatrician. Journal of Paediatrics and Child Health, 48 (2), E68-E72. doi: 10.1111/j.1440-1754.2011.02199.x

Extended newborn screening: An update for the general paediatrician

Current funding

  • 2024 - 2027
    Metabolic Medicine Research Clinical Trial in Ataxia-Telangiectasia
    BrAshA-T Ataxia-Telangiectasia Research Funding
    Open grant
  • 2023 - 2028
    Introducing Mitochondrial Donation into Australia: The mitoHOPE (Healthy Outcomes Pilot and Evaluation) Program (MRFF EPCDRI grant led by Monash)
    Monash University
    Open grant
  • 2023 - 2028
    Translational Centre for Speech Disorders (NHMRC Centre of Research Excellence administered by Murdoch Children's Research Institute)
    Murdoch Childrens Research Institute
    Open grant

Past funding

  • 2021 - 2024
    Repairing catalase function in A-T patients using a CAT-SKL therapeutic
    National Stem Cell Foundation of Australia Matched Funding Program
    Open grant
  • 2020 - 2023
    A Phase 2A/2B placebo-controlled randomised clinical trial to test the ability of triheptanoin to protect primary airway epithelial cells obtained from patients with ataxia-telangiectasia against....
    BrAshA-T Ataxia-Telangiectasia Research Funding
    Open grant
  • 2020 - 2022
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    Wesley Medical Research Ltd
    Open grant
  • 2020 - 2025
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2011 - 2013
    Early prediction of intellectual and cognitive-linguistic outcomes in children with treated galactosaemia
    APEX Foundation for Research into Intellectual Disability Ltd (AFRID)
    Open grant

Availability

Dr Dave Coman is:
Available for supervision

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Enquiries

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