Dr

Kevin Chen

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Background

Dr Chen’s research aims to understand the molecular details of how phosphatases, kinases and their associated proteins regulate cell signaling and homeostasis.

In 2011, Dr Chen completed his PhD on structural studies of macrophage proteins in Professor Jennifer Martin’s laboratory at The University of Queensland’s Institute for Molecular Bioscience.

In 2012, Dr Chen secured a postdoctoral research position at Academia Sinica (Taipei, Taiwan) to work on the molecular insights of phosphatases and kinases interaction using the combination of X-ray crystallography, small-angle X-ray scattering and chemical cross-linking coupled with mass spectrometry.

In 2015, he also received the Outstanding Young Postdoctoral Research Award from the Biophysics Society of Republic of China (Taiwan).

In June 2016, Dr Chen joined Associate Professor Brett Collins’ group at IMB, where he is working to understand how lipid kinases and lipid-binding proteins are involved in the regulation of cellular membrane transport.

Availability

Dr Kevin Chen is:
Available for supervision

Qualifications

  • Bachelor, Queensland University of Technology
  • Masters (Research) of Biotechnology, Queensland University of Technology
  • Doctor of Philosophy, The University of Queensland

Search Professor Kevin Chen’s works on UQ eSpace

27 works between 2009 and 2025
All (27) Journal Article (24) Conference Publication (3)

21 - 27 of 27 works

2014

Journal Article

Science signaling podcast: 14 October 2014

Meng, Tzu-Ching, Chen, Kai-En, Wang, Andrew H.-J. and Van Hook, Annalisa M. (2014). Science signaling podcast: 14 October 2014. Science Signaling, 7 (347), pc28-pc28. doi: 10.1126/scisignal.2005939

Science signaling podcast: 14 October 2014

2013

Journal Article

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

2012

Journal Article

The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

Walden, Patricia M., Heras, Begona, Chen, Kai-En, Halili, Maria A., Rimmer, Kieran, Sharma, Pooja, Scanlon, Martin J. and Martin, Jennifer L. (2012). The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production. Acta Crystallographica Section D-Biological Crystallography, 68 (10), 1290-1302. doi: 10.1107/S0907444912026388

The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

2012

Journal Article

The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer

Chen, Kai-En, Richards, Ayanthi A., Arrifin, Juliana K., Ross, Ian L., Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer L. (2012). The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallographica Section D: Biological Crystallography, 68 (6), 637-648. doi: 10.1107/S0907444912006592

The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer

2012

Journal Article

Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

Christie, Michelle P., Whitten, Andrew E., King, Gordon J., Hu, Shu-Hong, Jarrott, Russell J., Chen, Kai-En, Duff, Anthony P., Callow, Philip, Collins, Brett M., James, David E. and Martin, Jennifer L. (2012). Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proceedings of the National Academy of Sciences of the United States of America, 109 (25), 9816-9821. doi: 10.1073/pnas.1116975109

Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

2012

Journal Article

Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a

Mas, Caroline, Chen, Kai-En, Brereton, Ian M., Martin, Jennifer L. and Hill, Justine M. (2012). Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a. Biomolecular NMR Assignments, 7 (2), 117-120. doi: 10.1007/s12104-012-9390-1

Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a

2009

Journal Article

Interaction between plate make and protein in protein crystallisation screening

King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P. and Martin, Jennifer L. (2009). Interaction between plate make and protein in protein crystallisation screening. PLoS One, 4 (11) e7851, x-x. doi: 10.1371/journal.pone.0007851

Interaction between plate make and protein in protein crystallisation screening

Past funding

  • 2018 - 2019
    Stabilising the retromer protein complex with molecular chaperones for Alzheimer's and Parkinson's diseases
    Dementia Australia Research Foundation
    Open grant

Availability

Dr Kevin Chen is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Studying the role of the Retromer trafficking complex as a hub for regulating Rab GTPases at the endosome.

    Associate Advisor

    Other advisors: Professor Brett Collins

Completed supervision

Enquiries

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