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2024 Journal Article Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complexGuo, Qian, Chen, Kai-en, Gimenez-Andres, Manuel, Jellett, Adam P., Gao, Ya, Simonetti, Boris, Liu, Meihan, Danson, Chris M., Heesom, Kate J., Cullen, Peter J. and Collins, Brett M. (2024). Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex. Proceedings of the National Academy of Sciences, 121 (33) e2405041121, e2405041121. doi: 10.1073/pnas.2405041121 |
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2024 Journal Article Assembly and fission of tubular carriers mediating protein sorting in endosomesGopaldass, Navin, Chen, Kai-En, Collins, Brett and Mayer, Andreas (2024). Assembly and fission of tubular carriers mediating protein sorting in endosomes. Nature Reviews Molecular Cell Biology, 25 (10), 765-783. doi: 10.1038/s41580-024-00746-8 |
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2023 Journal Article Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndromeHealy, Michael D., McNally, Kerrie E., Butkovič, Rebeka, Chilton, Molly, Kato, Kohji, Sacharz, Joanna, McConville, Calum, Moody, Edmund R. R., Shaw, Shrestha, Planelles-Herrero, Vicente J., Yadav, Sathish K. N., Ross, Jennifer, Borucu, Ufuk, Palmer, Catherine S., Chen, Kai-En, Croll, Tristan I., Hall, Ryan J., Caruana, Nikeisha J., Ghai, Rajesh, Nguyen, Thi H. D., Heesom, Kate J., Saitoh, Shinji, Berger, Imre, Schaffitzel, Christiane, Williams, Tom A., Stroud, David A., Derivery, Emmanuel, Collins, Brett M. and Cullen, Peter J. (2023). Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell, 186 (10), 2219-2237.e29. doi: 10.1016/j.cell.2023.04.003 |
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2022 Journal Article SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recyclingSimonetti, Boris, Guo, Qian, Giménez-Andrés, Manuel, Chen, Kai-En, Moody, Edmund R. R., Evans, Ashley J., Chandra, Mintu, Danson, Chris M., Williams, Tom A., Collins, Brett M. and Cullen, Peter J. (2022). SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biology, 20 (4) e3001601, e3001601. doi: 10.1371/journal.pbio.3001601 |
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2022 Journal Article Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation systemWu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9 |
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2021 Journal Article De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complexChen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007 |
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2021 Journal Article Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003 |
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2021 Journal Article Community-wide experimental evaluation of the PROSS stability-design methodPeleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964 |
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2020 Journal Article Neuropilin-1 is a host factor for SARS-CoV-2 infectionDaly, James L., Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K., Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F., Horvath, Peter, Sessions, Richard B., Helenius, Ari, Hiscox, Julian A., Teesalu, Tambet, Matthews, David A., Davidson, Andrew D., Collins, Brett M., Cullen, Peter J. and Yamauchi, Yohei (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370 (6518), 861-865. doi: 10.1126/science.abd3072 |
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2019 Journal Article Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytesUgrankar, Rupali, Bowerman, Jade, Hariri, Hanaa, Chandra, Mintu, Chen, Kevin, Bossanyi, Marie-France, Datta, Sanchari, Rogers, Sean, Eckert, Kaitlyn M., Vale, Gonçalo, Victoria, Alexia, Fresquez, Joseph, McDonald, Jeffrey G., Jean, Steve, Collins, Brett M. and Henne, W. Mike (2019). Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Developmental Cell, 50 (5), 557-572.e5. doi: 10.1016/j.devcel.2019.07.021 |
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2019 Journal Article Towards a molecular understanding of endosomal trafficking by Retromer and RetrieverChen, Kai‐En, Healy, Michael D. and Collins, Brett M. (2019). Towards a molecular understanding of endosomal trafficking by Retromer and Retriever. Traffic, 20 (7) tra.12649, 465-478. doi: 10.1111/tra.12649 |
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2019 Journal Article Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificitiesChandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y |
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2018 Journal Article Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2αChen, Kai-En, Tillu, Vikas A., Chandra, Mintu and Collins, Brett M. (2018). Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α. Structure, 26 (12), 1612-1625.e4. doi: 10.1016/j.str.2018.08.010 |
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2018 Journal Article Structural insights into the architecture and membrane interactions of the conserved COMMD proteinsHealy, Michael D., Hospenthal, Manuela K., Hall, Ryan J., Chandra, Mintu, Chilton, Molly, Tillu, Vikas, Chen, Kai-En, Celligoi, Dion J., McDonald, Fiona J., Cullen, Peter J., Lott, J. Shaun, Collins, Brett M. and Ghai, Rajesh (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLife, 7 e35898. doi: 10.7554/elife.35898 |
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2015 Journal Article Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatasesChen, Kai-En, Li, Meng-Yen, Chou, Chia-Cheng, Ho, Meng-Ru, Chen, Guang-Chao, Meng, Tzu-Ching and Wang, Andrew H. -J. (2015). Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23 (4), 653-664. doi: 10.1016/j.str.2015.01.017 |
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2014 Journal Article Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formationChen, Kai-En, Lin, Shu-Yu, Wu, Mei-Ju, Ho, Meng-Ru, Santhanam, Abirami, Chou, Chia-Cheng, Meng, Tzu-Ching and Wang, Andrew H. -J. (2014). Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation. Science Signaling, 7 (347), ra98-ra98. doi: 10.1126/scisignal.2005722 |
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2014 Journal Article Science signaling podcast: 14 October 2014Meng, Tzu-Ching, Chen, Kai-En, Wang, Andrew H.-J. and Van Hook, Annalisa M. (2014). Science signaling podcast: 14 October 2014. Science Signaling, 7 (347), pc28-pc28. doi: 10.1126/scisignal.2005939 |
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2013 Journal Article The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidizedChen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558 |
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2012 Journal Article The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin productionWalden, Patricia M., Heras, Begona, Chen, Kai-En, Halili, Maria A., Rimmer, Kieran, Sharma, Pooja, Scanlon, Martin J. and Martin, Jennifer L. (2012). The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production. Acta Crystallographica Section D-Biological Crystallography, 68 (10), 1290-1302. doi: 10.1107/S0907444912026388 |
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2012 Journal Article The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimerChen, Kai-En, Richards, Ayanthi A., Arrifin, Juliana K., Ross, Ian L., Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer L. (2012). The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallographica Section D: Biological Crystallography, 68 (6), 637-648. doi: 10.1107/S0907444912006592 |
