Overview
Background
Dr Abu Sina is currently an NHMRC Emerging Leader Fellow at the Center for Personalized Nanomedicine, Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Australia. Prior to this, he served as a Visiting Scientist at the Dana-Farber Cancer Institute, Harvard University, and as a Visiting Research Fellow at the Irving Cancer Research Center, Columbia University, NY, USA.
Dr. Sina has earned both national and international acclaim for his notable contributions to advancing translational-focused nano-diagnostic technologies with a focus on early cancer detection from liquid biopsies. He is one of the few leaders in the world who is driving the liquid biopsy-based multi-cancer early detection (MCED) test program. He has had several media appearances so far which include interviews on national (Channel 9, Channel 7, ABC News, Fox News, etc.) and international Television (CBC News, CTV News Canada, etc.) and Radio (4EB, 4BC, ABC Perth, ABC Sunshine coast, SBS) outlets.
Actively participating in scholarly discussions, Dr. Sina has served as a Keynote Speaker, Invited Speaker, and Session Chair at various national and international conferences and seminars. His commitment to excellence has resulted in several prestigious awards, including the Metrohm-EDRACI Young Electrochemist Award 2021, the Queensland Health and Medical Research Award 2019 from the Queensland State Government of Australia, and recognition as a Fellow of the International Association of Advanced Materials.
Central to his aspirations is a vision to develop point-of-care diagnostic technologies with the potential to revolutionize early disease detection, thereby enhancing overall quality of life.
Availability
- Dr Abu Sina is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Dr. Sina's research is centered on the development of nanotechnologies for applications in liquid biopsy, addressing clinical challenges in medical diagnostics and precision oncology. His expertise spans diverse areas of basic and translational research, encompassing chemistry, molecular biology, nano-biotechnology, liquid biopsy, biosensing, and microfluidics, among others. Notably, his work has pioneered the field of "interfacial biosensing," overcoming limitations associated with existing biosensing techniques.
A standout achievement in his innovative portfolio is the establishment of a DNA nano-signature-based cancer test, widely acknowledged as the 10-minute universal cancer test. This groundbreaking development has garnered extensive coverage in major global news outlets, including CNN, Forbes, The Guardian, CTV News, Smithsonian Magazine, and the New York Post. CNN and BioScope, an online magazine, have recognized his discovery of the 10-minute cancer test as one of the "Top Discoveries/Advances for 2018."
Throughout his research career, marked by 52 publications (12 as the First author and 16 as the corresponding author) and a patent (US Patent App. 17286379), Dr. Sina has accumulated 1865 citations, achieving an H-index of 21 and an i10-index of 33 (Source: Google Scholar). His research has been published in high-impact, discipline-ranked journals such as Nature Communications, Accounts of Chemical Research, ACS Nano, Science Advances, and Advanced Functional Materials.
Dedicated to early cancer detection and personalized treatment, Dr. Sina's research program has secured over $1.5 million in grant funding from government agencies and industries. His research outputs rank in the top 25% for citation with an FWCI score >2. The impact is evident through citations in 1,110 documents across 88 countries and in 23 different subject categories (Scopus, Oct 2023). Notably, he has been cited by authors from over 160 institutions, including Harvard Medical School and the University of California.
Works
Search Professor Abu Sina’s works on UQ eSpace
2024
Journal Article
A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue
Shanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192
2024
Journal Article
Functional genomic analysis of the isolated potential probiotic <i>Lactobacillus delbrueckii</i> subsp. <i>indicus</i> TY-11 and its comparison with other <i>Lactobacillus delbrueckii</i> strains
Jakaria Al-Mujahidy, Sk. Md., Kryukov, Kirill, Ikeo, Kazuho, Saito, Kei, Uddin, Md. Ekhlas and Ibn Sina, Abu Ali (2024). Functional genomic analysis of the isolated potential probiotic Lactobacillus delbrueckii subsp. indicus TY-11 and its comparison with other Lactobacillus delbrueckii strains. Microbiology Spectrum, 12 (7), e0347023. doi: 10.1128/spectrum.03470-23
2024
Journal Article
A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells
Ahmed, Emtiaz, Masud, Mostafa Kamal, Komatineni, Prathyusha, Dey, Shuvashis, Lobb, Richard, Hossain, Md Shahriar A., Möller, Andreas, Yamauchi, Yusuke, Sina, Abu Ali Ibn and Trau, Matt (2024). A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells. Biosensors and Bioelectronics, 249 115984, 1-9. doi: 10.1016/j.bios.2023.115984
2023
Conference Publication
Methylated Whole Genome Cell-Free DNA Sequencing before Chimeric Antigen Receptor T-Cell Therapy for Large B-Cell Lymphoma Predicts Treatment Outcomes
Cherng, Hua-Jay J., Yang, Xiaojing, Yancey, Ryan, Gordillo, Christian A, Piorczynski, Ted B., Chan, Hei T., Ofori, Kenneth N., Bhagat, Govind, Califano, Andrea, Pro, Barbara, Booher, Keith, Amengual, Jennifer E., Reshef, Ran and Sina, Abu A. I. (2023). Methylated Whole Genome Cell-Free DNA Sequencing before Chimeric Antigen Receptor T-Cell Therapy for Large B-Cell Lymphoma Predicts Treatment Outcomes. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-178376
2023
Conference Publication
Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC
O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432
2023
Journal Article
Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening
Khamis, Ramlah, Shanmugasundaram, Karthik B., Zhou, Quan, Lu, Jennifer, Zhang, Zhen, Hill, Michelle M., Sina, Abu Ali Ibn, Trau, Matt and Wuethrich, Alain (2023). Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening. ACS Applied Nano Materials, 6 (21), 20190-20197. doi: 10.1021/acsanm.3c03987
2023
Journal Article
A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12) ARTN 2300059. doi: 10.1002/adsr.202300059
2023
Journal Article
Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring
Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519
2023
Journal Article
Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
2022
Journal Article
Assessment of serum uric acid, urea, and glucose levels and associated factors among breast cancer patients attending a tertiary hospital in Bahirdar, Ethiopia: a comparative cross-sectional study
Kebede, Tinfash, Melak, Tadele, Sina, Abu Ali Ibn and Fasil, Alebachew (2022). Assessment of serum uric acid, urea, and glucose levels and associated factors among breast cancer patients attending a tertiary hospital in Bahirdar, Ethiopia: a comparative cross-sectional study. Ethiopian Journal of Health Sciences, 32 (6), 1183-1192. doi: 10.4314/ejhs.v32i6.16
2022
Journal Article
Hydrogel nanoarchitectonics: an evolving paradigm for ultrasensitive biosensing
Nishat, Zakia Sultana, Hossain, Tanvir, Islam, Md. Nazmul, Phan, Hoang‐Phuong, Wahab, Md A., Moni, Mohammad Ali, Salomon, Carlos, Amin, Mohammed A., Sina, Abu Ali Ibn, Hossain, Md Shahriar A., Kaneti, Yusuf Valentino, Yamauchi, Yusuke and Masud, Mostafa Kamal (2022). Hydrogel nanoarchitectonics: an evolving paradigm for ultrasensitive biosensing. Small, 18 (26) 2107571, 2107571. doi: 10.1002/smll.202107571
2022
Journal Article
An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers
Dey, Shuvashis, Ahmed, Emtiaz, Somvanshi, Pranjal Satishchandra, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2022). An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors, 10 (3) 93, 93. doi: 10.3390/chemosensors10030093
2022
Journal Article
Opportunities for early cancer detection: the rise of ctDNA methylation-based pan-cancer screening technologies
Constantin, Nicolas, Sina, Abu Ali Ibn, Korbie, Darren and Trau, Matt (2022). Opportunities for early cancer detection: the rise of ctDNA methylation-based pan-cancer screening technologies. Epigenomes, 6 (1) 6, 6. doi: 10.3390/epigenomes6010006
2022
Journal Article
Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy
Shanmugasundaram, Karthik Balaji, Li, Junrong, Sina, Abu Ibn, Wuethrich, Alain and Trau, Matt (2022). Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy. Materials Advances, 3 (3), 1459-1471. doi: 10.1039/d1ma00848j
2021
Journal Article
Simultaneous detection of dual food adulterants using graphene oxide and gold nanoparticle based surface enhanced Raman scattering duplex DNA biosensor
Khalil, Ibrahim, Yehye, Wageeh A., Muhd Julkapli, Nurhidayatullaili, Ibn Sina, Abu Ali, Islam Chowdhury, Faisal, Khandaker, Mayeen Uddin, Hsiao, Vincent K.S. and Basirun, Wan Jefrey (2021). Simultaneous detection of dual food adulterants using graphene oxide and gold nanoparticle based surface enhanced Raman scattering duplex DNA biosensor. Vibrational Spectroscopy, 116 103293, 103293. doi: 10.1016/j.vibspec.2021.103293
2021
Journal Article
Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
2021
Journal Article
In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Wang, Jing, Behren, Andreas, Antaw, Fiach, Wang, Yuling, Sina, Abu Ali Ibn and Trau, Matt (2021). In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment. ACS Nano, 15 (7) acsnano.0c10008, 11231-11243. doi: 10.1021/acsnano.0c10008
2021
Journal Article
A study on the interfacial compatibility, microstructure and physico-chemical properties of polyimide/organically modified silica nanocomposite membrane
Wahab, Md, Karim, Mohammad, Aijaz, Muhammad, Salahuddin, Bidita, Aziz, Shazed and Sina, Abu (2021). A study on the interfacial compatibility, microstructure and physico-chemical properties of polyimide/organically modified silica nanocomposite membrane. Polymers, 13 (8) 1328, 1-11. doi: 10.3390/polym13081328
2021
Book Chapter
Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor
Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20
2021
Journal Article
A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N. and Trau, Matt (2021). A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nature Communications, 12 (1) 1087, 1-12. doi: 10.1038/s41467-021-21431-w
Supervision
Availability
- Dr Abu Sina is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Multiplex microdevice for the detection of DNA Methylation
Methylation of DNA is a type of epigenetic signatures that defines the eukaryotic cell’s identity by regulating gene expression. Aberrant methylation in the genome can deregulate the gene expression pathways leading to diseases like cancer. Thus, DNA methylation has been regarded as one of the important biomarkers for cancer. Recent years have seen tremendous advancement in methylation based biomarker discovery providing abundant information about the genomic printing. However, cancer is a versatile disease that often needs multiple biomarker analysis for accurate detection. Current practice in detecting methylation biomarkers in clinic is largely affected by expensive sequencing technique. Recent advancements in electrochemical and optical biosensors have shown great promise in developing inexpensive multiplex platform. Despite of their significant improvement in sensitivity, these methods are restricted by major technological challenges including functionalization of sensor surface, long analysis procedure and invasive sampling. We have recently developed an interfacial biosensing technique to identify DNA methylation using gold-DNA affinity which obviates the need for sensor surface modification. In this study, we aim to develop a novel multiplex micro-device comprising an array of microelectrodes for directly detecting the genomic methylation biomarkers with the mechanism of interfacial adsorption between DNA and metal surfaces. These microelectrodes can significantly increase the assay sensitivity due to the high signal to noise ratio. We believe that this micro-fabricated multiplex platform will find broad applications as simple diagnostic tool in the clinic.
Supervision history
Current supervision
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Doctor Philosophy
A potential pan-cancer diagnostic utilizing DNA methylation landscapes
Principal Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja
-
Doctor Philosophy
Single molecule sensing on nanopillars: Reading complex molecular circuits
Principal Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich, Dr Selvakumar Edwardraja
-
Doctor Philosophy
Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer
Associate Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich
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Doctor Philosophy
Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles
Associate Advisor
Other advisors: Professor Matt Trau, Dr Mitchell Stark, Dr Alain Wuethrich
Completed supervision
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2024
Doctor Philosophy
Advanced Micro and Nano Engineered Sensors for Post Translational Modification based Liquid Biopsy Analysis of Cancer
Associate Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich
-
2024
Doctor Philosophy
Clinical Epigenetics: Technology Development for Biomarkers of Human Health and Diseases
Associate Advisor
Other advisors: Dr Darren Korbie, Dr Alain Wuethrich, Professor Matt Trau
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2023
Doctor Philosophy
Novel Nanotechnology Platforms for Cancer Diagnostics
Associate Advisor
Other advisors: Dr Darren Korbie, Professor Matt Trau
Media
Enquiries
Contact Dr Abu Sina directly for media enquiries about:
- Biosensing
- Cancer Diagnostics
- Liquid biopsy
- Nanotechnology
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