Overview
Background
Dr Luan is the postdoctoral fellow of Neurodegenerative Pathobiology laboratory in Queensland Brain Institute. Dr Luan's research aims to understand the molecular and cellular mechanism for human neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). His research focuses on the cellular stress responses and novel biochemical pathways in the pathogenesis of these diseases. Dr Luan will use biochemical, immunohistochemistry and AAVs techniques in a well-established pre-clinical transgenic mouse model. His goal is to discover new potential therapeutic targets in order to help patients who suffer these diseases.
Availability
- Dr Wei Luan is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma of Natural Science, University of the Chinese Academy of Science
Research interests
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Drug discovery for motor neuron disease
Dr Luan is the postdoctoral fellow of Neurodegenerative Pathobiology laboratory in Queensland Brain Institute. Dr Luan's research aims to understand the molecular and cellular mechanism for human neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). My research focuses on the cellular stress responses and novel biochemical pathways in the pathogenesis of these diseases. My goal is to discover new potential therapeutic targets in order to help patients who suffer these diseases.
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Characterisation of non-motor phenotypes in transgenic mice for motor neuron disease
Dr Luan's research aims to understand the molecular and cellular mechanism for the cognitive and behavioral changes of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). My research focuses on the underlying pathogenic mechanisms of these non-motor dysfunction. My goal is to discover new potential therapeutic targets in order to reverse cognitive and behavioral abnormalities in patients who suffer these diseases.
Research impacts
Dr Luan is an enthusiastic neuroscientist at Queensland Brain Institute.Dr Luan's research covers a unique range of human neuropsychiatric disorders and neurodegenerative diseases. His previous research in rodent models provides first-hand in vivo evidence that vitamin D deficiency in pregnancy significantly disrupts the neurodevelopment of dopamine neurons, essential to the normal brain and involved in a variety of human neuropsychological disorders. Dr Luan's follow-up studies utilising a dietary form of vitamin D in pregnant rodent models successfully prevents the behavioural abnormalities of high relevance to schizophrenia and autism, suggesting a promising strategy in the prevention of offspring from adverse psychiatric outcomes. Dr Luan has recently joined the worldly-recognised neurodegeneration pathobiology lab led by Dr Adam Walker at QBI. He has been actively employing cutting-edge biochemistry, microscopy and well-established mouse model systems to investigate the molecular causes of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) and frontotemporal dementia (FTD). Dr Luan's research focuses on the cell stress response that is activated rapidly in mice of MND/FTD and will characterise new protein targets to prevent, treat, and cure these devastating diseases.
Works
Search Professor Wei Luan’s works on UQ eSpace
2024
Journal Article
A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
2023
Journal Article
Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
2022
Journal Article
Prenatal hypoxia alters the early ontogeny of dopamine neurons
Brandon, Anastasia, Cui, Xiaoying, Luan, Wei, Ali, Asad Amanat, Pertile, Renata Aparecida Nedel, Alexander, Suzanne Adele and Eyles, Darryl Walter (2022). Prenatal hypoxia alters the early ontogeny of dopamine neurons. Translational Psychiatry, 12 (1) 238, 238. doi: 10.1038/s41398-022-02005-w
2018
Journal Article
Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation
Luan, Wei, Hammond, Luke Alexander, Vuillermot, Stephanie, Meyer, Urs and Eyles, Darryl Walter (2018). Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation. Scientific Reports, 8 (1) 9741, 9741. doi: 10.1038/s41598-018-28090-w
2017
Conference Publication
Gestational vitamin d treatment blocks behavioural phenotypes relevant to schizophrenia induced by maternal immune activation
Luan, W. (2017). Gestational vitamin d treatment blocks behavioural phenotypes relevant to schizophrenia induced by maternal immune activation. ISN-ESN Meeting, Paris, France, 20-24 August 2017. Hoboken, NJ United States: Wiley-Blackwell.
2017
Journal Article
Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon
Luan, Wei, Hammond, Luke Alexander, Cotter, Edmund, Osborne, Geoffrey William, Alexander, Suzanne Adele, Nink, Virginia, Cui, Xiaoying and Eyles, Darryl Walter (2017). Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon. Molecular Neurobiology, 55 (3), 2443-2453. doi: 10.1007/s12035-017-0497-3
2017
Journal Article
Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation
Vuillermot, Stephanie, Luan, Wei, Meyer, Urs and Eyles, Darryl (2017). Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 8 (9) 9, 9. doi: 10.1186/s13229-017-0125-0
2015
Conference Publication
Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase
Luan, W., Alexander, S., Osborne, G., Nink, V., Cui, X. and Eyles, D. (2015). Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188
2013
Journal Article
Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway
Mou, Haiwei, Li, Zongmeng, Yao, Pengle, Zhuo, Shu, Luan, Wei, Deng, Bo, Qian, Lihua, Yang, Mengmei, Mei, Hong and Le, Yingying (2013). Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. The International Journal of Biochemistry and Cell Biology, 45 (3), 684-691. doi: 10.1016/j.biocel.2012.12.003
2010
Journal Article
Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses
Luan, Wei, Li, Fuhua, Zhang, Jiquan, Wen, Rong, Li, Yutao and Xiang, Jianhai (2010). Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses. Cell Stress & Chaperones, 15 (1), 83-93. doi: 10.1007/s12192-009-0124-y
2009
Journal Article
Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia
Li, Fuhua, Luan, Wei, Zhang, Chengsong, Zhang, Jiquan, Wang, Bing, Xie, Yusu, Li, Shihao and Xiang, Jianhai (2009). Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia. Cell Stress & Chaperones, 14 (2), 161-172. doi: 10.1007/s12192-008-0069-6
2009
Journal Article
Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis
Luan, Wei, Li, Fuhua, Zhang, Jiquan, Wang, Bing and Xiang, Jianhai (2009). Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis. Molecular Biology Reports, 36 (2), 289-298. doi: 10.1007/s11033-007-9178-z
2008
Journal Article
Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio
Wang, Bing, Li, Fuhua, Luan, Wei, Xie, Yusu, Zhang, Chengsong, Luo, Zhan, Gui, Lang, Yan, Hui and Xiang, Jianhai (2008). Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio. Marine Biotechnology, 10 (6), 664-675. doi: 10.1007/s10126-008-9105-x
2008
Journal Article
A novel tumor necrosis factor ligand superfamily member (CsTL) from Ciona savignyi: Molecular identification and expression analysis
Zhang, Xiaoming, Luan, Wei, Jin, Songjun and Xiang, Jianhai (2008). A novel tumor necrosis factor ligand superfamily member (CsTL) from Ciona savignyi: Molecular identification and expression analysis. Developmental & Comparative Immunology, 32 (11), 1362-1373. doi: 10.1016/j.dci.2008.05.009
2007
Journal Article
A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full-length cDNA cloning, tissue localization and expression profile after challenge
Liu, Yi-Chen, Li, Fu-Hua, Wang, Bing, Dong, Bo, Zhang, Qing-Li, Luan, Wei, Zhang, Xiao-Jun and Xiang, Jian-Hai (2007). A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full-length cDNA cloning, tissue localization and expression profile after challenge. Fish and Shellfish Immunology, 22 (5), 576-588. doi: 10.1016/j.fsi.2006.08.004
2007
Journal Article
Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis
Liu, Yi-Chen, Li, Fu-Hua, Dong, Bo, Wang, Bing, Luan, Wei, Zhang, Xiao-Jun, Zhang, Liu-Suo and Xiang, Jian-Hai (2007). Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis. Molecular Immunology, 44 (4), 598-607. doi: 10.1016/j.molimm.2006.01.015
Funding
Current funding
Supervision
Availability
- Dr Wei Luan is:
- Available for supervision
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Supervision history
Completed supervision
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2021
Master Philosophy
Prenatal Hypoxia Alters the Ontogeny of Dopamine Neurons
Associate Advisor
Other advisors: Professor Darryl Eyles
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2018
Master Philosophy
Maternal Immune Activation adversely affects the ontogeny of dopamine neurons. Is Vitamin D neuroprotective?
Associate Advisor
Other advisors: Professor Darryl Eyles
Media
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