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Dr Wei Luan
Dr

Wei Luan

Email: 
Phone: 
+61 7 334 66362

Overview

Background

Dr Luan is the postdoctoral fellow of Neurodegenerative Pathobiology laboratory in Queensland Brain Institute. Dr Luan's research aims to understand the molecular and cellular mechanism for human neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). His research focuses on the cellular stress responses and novel biochemical pathways in the pathogenesis of these diseases. Dr Luan will use biochemical, immunohistochemistry and AAVs techniques in a well-established pre-clinical transgenic mouse model. His goal is to discover new potential therapeutic targets in order to help patients who suffer these diseases.

Availability

Dr Wei Luan is:
Available for supervision

Qualifications

  • Doctoral Diploma of Natural Science, University of the Chinese Academy of Science

Research interests

  • Drug discovery for motor neuron disease

    Dr Luan is the postdoctoral fellow of Neurodegenerative Pathobiology laboratory in Queensland Brain Institute. Dr Luan's research aims to understand the molecular and cellular mechanism for human neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). My research focuses on the cellular stress responses and novel biochemical pathways in the pathogenesis of these diseases. My goal is to discover new potential therapeutic targets in order to help patients who suffer these diseases.

  • Characterisation of non-motor phenotypes in transgenic mice for motor neuron disease

    Dr Luan's research aims to understand the molecular and cellular mechanism for the cognitive and behavioral changes of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). My research focuses on the underlying pathogenic mechanisms of these non-motor dysfunction. My goal is to discover new potential therapeutic targets in order to reverse cognitive and behavioral abnormalities in patients who suffer these diseases.

Research impacts

Dr Luan is an enthusiastic neuroscientist at Queensland Brain Institute.Dr Luan's research covers a unique range of human neuropsychiatric disorders and neurodegenerative diseases. His previous research in rodent models provides first-hand in vivo evidence that vitamin D deficiency in pregnancy significantly disrupts the neurodevelopment of dopamine neurons, essential to the normal brain and involved in a variety of human neuropsychological disorders. Dr Luan's follow-up studies utilising a dietary form of vitamin D in pregnant rodent models successfully prevents the behavioural abnormalities of high relevance to schizophrenia and autism, suggesting a promising strategy in the prevention of offspring from adverse psychiatric outcomes. Dr Luan has recently joined the worldly-recognised neurodegeneration pathobiology lab led by Dr Adam Walker at QBI. He has been actively employing cutting-edge biochemistry, microscopy and well-established mouse model systems to investigate the molecular causes of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) and frontotemporal dementia (FTD). Dr Luan's research focuses on the cell stress response that is activated rapidly in mice of MND/FTD and will characterise new protein targets to prevent, treat, and cure these devastating diseases.

Works

Search Professor Wei Luan’s works on UQ eSpace

16 works between 2007 and 2024

1 - 16 of 16 works

2024

Journal Article

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

2023

Journal Article

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

2022

Journal Article

Prenatal hypoxia alters the early ontogeny of dopamine neurons

Brandon, Anastasia, Cui, Xiaoying, Luan, Wei, Ali, Asad Amanat, Pertile, Renata Aparecida Nedel, Alexander, Suzanne Adele and Eyles, Darryl Walter (2022). Prenatal hypoxia alters the early ontogeny of dopamine neurons. Translational Psychiatry, 12 (1) 238, 238. doi: 10.1038/s41398-022-02005-w

Prenatal hypoxia alters the early ontogeny of dopamine neurons

2018

Journal Article

Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation

Luan, Wei, Hammond, Luke Alexander, Vuillermot, Stephanie, Meyer, Urs and Eyles, Darryl Walter (2018). Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation. Scientific Reports, 8 (1) 9741, 9741. doi: 10.1038/s41598-018-28090-w

Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation

2017

Conference Publication

Gestational vitamin d treatment blocks behavioural phenotypes relevant to schizophrenia induced by maternal immune activation

Luan, W. (2017). Gestational vitamin d treatment blocks behavioural phenotypes relevant to schizophrenia induced by maternal immune activation. ISN-ESN Meeting, Paris, France, 20-24 August 2017. Hoboken, NJ United States: Wiley-Blackwell.

Gestational vitamin d treatment blocks behavioural phenotypes relevant to schizophrenia induced by maternal immune activation

2017

Journal Article

Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon

Luan, Wei, Hammond, Luke Alexander, Cotter, Edmund, Osborne, Geoffrey William, Alexander, Suzanne Adele, Nink, Virginia, Cui, Xiaoying and Eyles, Darryl Walter (2017). Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon. Molecular Neurobiology, 55 (3), 2443-2453. doi: 10.1007/s12035-017-0497-3

Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon

2017

Journal Article

Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation

Vuillermot, Stephanie, Luan, Wei, Meyer, Urs and Eyles, Darryl (2017). Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 8 (9) 9, 9. doi: 10.1186/s13229-017-0125-0

Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation

2015

Conference Publication

Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase

Luan, W., Alexander, S., Osborne, G., Nink, V., Cui, X. and Eyles, D. (2015). Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188

Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase

2013

Journal Article

Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

Mou, Haiwei, Li, Zongmeng, Yao, Pengle, Zhuo, Shu, Luan, Wei, Deng, Bo, Qian, Lihua, Yang, Mengmei, Mei, Hong and Le, Yingying (2013). Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. The International Journal of Biochemistry and Cell Biology, 45 (3), 684-691. doi: 10.1016/j.biocel.2012.12.003

Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

2010

Journal Article

Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses

Luan, Wei, Li, Fuhua, Zhang, Jiquan, Wen, Rong, Li, Yutao and Xiang, Jianhai (2010). Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses. Cell Stress & Chaperones, 15 (1), 83-93. doi: 10.1007/s12192-009-0124-y

Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses

2009

Journal Article

Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia

Li, Fuhua, Luan, Wei, Zhang, Chengsong, Zhang, Jiquan, Wang, Bing, Xie, Yusu, Li, Shihao and Xiang, Jianhai (2009). Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia. Cell Stress & Chaperones, 14 (2), 161-172. doi: 10.1007/s12192-008-0069-6

Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia

2009

Journal Article

Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis

Luan, Wei, Li, Fuhua, Zhang, Jiquan, Wang, Bing and Xiang, Jianhai (2009). Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis. Molecular Biology Reports, 36 (2), 289-298. doi: 10.1007/s11033-007-9178-z

Cloning and expression of glucose regulated protein 78 (GRP78) in Fenneropenaeus chinensis

2008

Journal Article

Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio

Wang, Bing, Li, Fuhua, Luan, Wei, Xie, Yusu, Zhang, Chengsong, Luo, Zhan, Gui, Lang, Yan, Hui and Xiang, Jianhai (2008). Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio. Marine Biotechnology, 10 (6), 664-675. doi: 10.1007/s10126-008-9105-x

Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio

2008

Journal Article

A novel tumor necrosis factor ligand superfamily member (CsTL) from Ciona savignyi: Molecular identification and expression analysis

Zhang, Xiaoming, Luan, Wei, Jin, Songjun and Xiang, Jianhai (2008). A novel tumor necrosis factor ligand superfamily member (CsTL) from Ciona savignyi: Molecular identification and expression analysis. Developmental & Comparative Immunology, 32 (11), 1362-1373. doi: 10.1016/j.dci.2008.05.009

A novel tumor necrosis factor ligand superfamily member (CsTL) from Ciona savignyi: Molecular identification and expression analysis

2007

Journal Article

A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full-length cDNA cloning, tissue localization and expression profile after challenge

Liu, Yi-Chen, Li, Fu-Hua, Wang, Bing, Dong, Bo, Zhang, Qing-Li, Luan, Wei, Zhang, Xiao-Jun and Xiang, Jian-Hai (2007). A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full-length cDNA cloning, tissue localization and expression profile after challenge. Fish and Shellfish Immunology, 22 (5), 576-588. doi: 10.1016/j.fsi.2006.08.004

A transglutaminase from Chinese shrimp (Fenneropenaeus chinensis), full-length cDNA cloning, tissue localization and expression profile after challenge

2007

Journal Article

Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis

Liu, Yi-Chen, Li, Fu-Hua, Dong, Bo, Wang, Bing, Luan, Wei, Zhang, Xiao-Jun, Zhang, Liu-Suo and Xiang, Jian-Hai (2007). Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis. Molecular Immunology, 44 (4), 598-607. doi: 10.1016/j.molimm.2006.01.015

Molecular cloning, characterization and expression analysis of a putative C-type lectin (Fclectin) gene in Chinese shrimp Fenneropenaeus chinensis

Funding

Current funding

  • 2024 - 2025
    Synaptic mechanisms of non-motor dysfunction in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant

Supervision

Availability

Dr Wei Luan is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

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