Emerita Professor Jenny Martin
Emerita Professor

Jenny Martin

Email: 

Background

Jenny Martin trained as a pharmacist at the Victorian College of Pharmacy (VCP), where she was awarded the Gold Medal for top student over the BPharm course. After completing an MPharm in computational chemistry at the College, Jenny moved to Oxford University for a PhD by research in protein crystallography and drug design. Her DPhil was supported by a prestigious 1851 Science Research Scholarship and several other competitive scholarships. Jenny then undertook two years of postdoctoral research at Rockefeller University in New York, before returning to Australia in 1993 to establish the first protein crystallography laboratory in Queensland. Since then, she has held ARC QEII, ARC Professorial and NHMRC Fellowships and is currently an ARC Australian Laureate Fellow at the Institute for Molecular Bioscience, University of Queensland. Jenny is the recipient of many honours including the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist award, and the Women in Biotech Outstanding Outstanding Biotechnology Achievement Award.

Availability

Emerita Professor Jenny Martin is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Oxford

Research impacts

Prof Martin has contributed to knowledge through more than 110 crystal structures deposited into the protein data bank. She has also contributed to the development of patented antidiabetics, HIV-protease inhibitors, and patents leading to the development of conotoxin drugs that progressed to clinical trials. In addition, through a consultancy with PanBIO (now Inverness Medical Innovations) Prof Martin contributed to a patented diagnostic for herpes simplex virus. She has also held ARC Linkage projects with biotech companies Alchemia, Hexima and Biota leading to fundamental and applied research outcomes. As a leader in her field, Jenny has chaired the National Committee for Crystallography of the Australian Academy of Science, is a past President of the Society for Crystallographers in Australia and New Zealand and former member of the Scientific Advisory Committee of the Australian Synchrotron.

Search Professor Jenny Martin’s works on UQ eSpace

210 works between 1984 and 2022
All (210) Journal Article (177) Book Chapter (9) Conference Publication (19) Other Outputs (5)

141 - 160 of 210 works

2006

Journal Article

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

2006

Conference Publication

Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase

Forwood, J K, Mouradov, D. A., Guncar, G, Mafori, M., Serek, R. A., Martin, J L, Huber, T L and Kobe, B (2006). Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase. ComBio 2006, Brisbane, 24-28 Sept, 2006.

Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase

2005

Journal Article

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis

Gee, Christine L., Tyndall, Joel D. A., Grunewald, Gary L., Wu, Qian, McLeish, Michael J. and Martin, Jennifer L. (2005). Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis. Biochemistry, 44 (51), 16875-16885. doi: 10.1021/bi051636b

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis

2005

Journal Article

Protein crystallography and the Australian synchrotron

Martin, J. L. (2005). Protein crystallography and the Australian synchrotron. Australian Biochemist, 36 (1), 51-54.

Protein crystallography and the Australian synchrotron

2005

Journal Article

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

2005

Journal Article

Post-crystallization treatments for improving diffraction quality of protein crystals

Heras, B. and Martin, J. L. (2005). Post-crystallization treatments for improving diffraction quality of protein crystals. Acta Crystallographica Section D: Biological Crystallography, 61 (Part 9), 1173-1180. doi: 10.1107/S0907444905019451

Post-crystallization treatments for improving diffraction quality of protein crystals

2005

Book Chapter

Human SULT1A SULTs

Hempel, N., Barnett, A., Gamage, N., Duggleby, R.G., Windmill, K. F., Martin, J. L. and McManus, M. E. (2005). Human SULT1A SULTs. Human Cytosolic Sulfotransferases. (pp. 179-230) edited by Pacifici, Gian Maria and Coughtrie, Michael W. H.. Boca Raton, FL, USA: Taylor & Francis Group, LLC (CRC Press).

Human SULT1A SULTs

2005

Journal Article

The structure of human SULT1A1 crystallized with estradiol: An insight into active site plasticity and substrate inhibition with multi-ring substrates

Gamage, N. U., Tsvetanov, S., Duggleby, R. G., McManus, M. E. and Martin, J. L. (2005). The structure of human SULT1A1 crystallized with estradiol: An insight into active site plasticity and substrate inhibition with multi-ring substrates. Journal of Biological Chemistry, 280 (50), 41482-41486. doi: 10.1074/jbc.M508289200

The structure of human SULT1A1 crystallized with estradiol: An insight into active site plasticity and substrate inhibition with multi-ring substrates

2005

Journal Article

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

2005

Journal Article

Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active

Gee, C. L., Nourse, A., Hsin, A. Y., Wu, Q., Tyndall, J. D., Grunewald, G. L., McLeish, M. J. and Martin, J. L. (2005). Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1750 (1), 82-92. doi: 10.1016/j.bbapap.2005.03.006

Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active

2005

Journal Article

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

2005

Journal Article

Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase

Wu, Q., Gee, C. L., Lin, F., Tyndall, J. D., Martin, J. L., Grunewald, G. L. and McLeish, M. J. (2005). Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 48 (23), 7243-7252. doi: 10.1021/jm050568o

Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase

2004

Journal Article

The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli

Edeling, Melissa A., Ahuja, Umesh, Heras, Begoña, Thony-Meyer, Linda and Martin, Jennifer L. (2004). The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli. Journal of Bacteriology, 186 (12), 4030-4033. doi: 10.1128/JB.186.12.4030-4033.2004

The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli

2004

Journal Article

Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3

Barnett, Amanda C., Tsvetanov, Sergey, Gamage, Niranjali, Martin, Jennifer L., Duggleby, Ronald G. and McManus, Michael E. (2004). Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3. The Journal of Biological Chemistry, 279 (18), 18799-18805. doi: 10.1074/jbc.M312253200

Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3

2004

Journal Article

Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics

Listwan, P., Martin, J. L., Kobe, B. and Cowieson, N. P. (2004). Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics. Australian Biochemist, 35 (2), 43-46.

Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics

2004

Journal Article

Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide

Heras, B., Edeling, M. A., Schirra, H. J., Raina, S. and Martin, J. L. (2004). Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide. Proceedings of The National Academy of Sciences of The United States of America, 101 (24), 8876-8881. doi: 10.1073/pnas.0402769101

Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide

2004

Journal Article

Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries

Reid, Robert C., Pattenden, Lenard K., Tyndall, Joel D. A., Martin, Jennifer L., Walsh, Terry and Fairlie, David P. (2004). Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47 (7), 1641-1651. doi: 10.1021/jm030337m

Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries

2004

Journal Article

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase

McMillan, F. M., Archbold, J., McLeish, M. J., Caine, J. M., Criscione, K. R., Grunewald, G. L. and Martin, J. L. (2004). Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 47 (1), 37-44. doi: 10.1021/jm0205752

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase

2003

Journal Article

Comparison of three commercial sparse-matrix crystallization screens

Wooh, J. W., Kidd, R. D., Martin, J. L. and Kobe, B. (2003). Comparison of three commercial sparse-matrix crystallization screens. Acta Crystallographica Section D: Biological Crystallography, 59 (4), 769-772. doi: 10.1107/S0907444903002919

Comparison of three commercial sparse-matrix crystallization screens

2003

Journal Article

Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition

Gamage, Niranjali U., Duggleby, Ronald G., Barnett, Amanda C., Tresillian, Michael, Latham, Catherine F., Liyou, Nancy E., McManus, Michael E. and Martin, Jennifer L. (2003). Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. Journal of Biological Chemistry, 278 (9), 7655-7662. doi: 10.1074/jbc.M207246200

Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition

Past funding

  • 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition (NHMRC Project Grant administered by Griffith University)
    Open grant
  • 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2016 - 2018
    DsbA inhibitors: from hits to leads
    NHMRC Project Grant
    Open grant
  • 2016
    Structure and function of human zinc transporter membrane proteins
    ARC Discovery Projects
    Open grant
  • 2015
    Protein Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Membrane proteins in innate immunity
    ARC Discovery Projects
    Open grant
  • 2012 - 2013
    Overcoming membrane protein research roadblocks: A Queensland facility for membrane protein production and crystallisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    High- throughput Fourier Transform Infrared (FTIR) spectrometer.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Queensland International Fellowship: Membrane Protein Structure Techniques
    Queensland International Fellowships
    Open grant
  • 2010 - 2013
    Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding (ARC Linkage Project Grant, administered by Monash University)
    Monash University
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2014
    Towards antibacterials without resistance
    ARC Australian Laureate Fellowships
    Open grant
  • 2009
    Characterization of the Munc 18c-Sx4 Complex
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2009 - 2013
    How the SNARE:SM machinery regulates glucose transport in fat cells
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Design and use of human hematopoietic prostaglandin D2 synthase inhibitors in allergic asthma and bone diseases
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Inhibitors Of West Nile Virus Protease As Antiviral Drugs
    NHMRC Project Grant
    Open grant
  • 2007 - 2011
    Macrophage proteins: structure, function and e-science
    ARC Discovery Projects
    Open grant
  • 2007 - 2015
    NHMRC Senior Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2006 - 2008
    Deciphering the molecular basis of SM regulation of exocytosis
    NHMRC Project Grant
    Open grant
  • 2006
    e-Research Infrastructure for the Molecular and Materials Structure Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Innovative Approaches to Membrane Protein Crystallography & Drug Discovery
    ARC Discovery Projects
    Open grant
  • 2006
    Small Angle Scattering Facility for the Materials and Biological Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack
    ARC Linkage Projects
    Open grant
  • 2005
    A New Generation Biosensor and Fluorescence Facility for Proteomic
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
    NHMRC Project Grant
    Open grant
  • 2004
    Structural biology of macromolecular assemblies as part of the visual cell program
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004 - 2006
    Structure and function of novel macrophage proteins using high throughput crystallography
    ARC Discovery Projects
    Open grant
  • 2004
    The Australian Protease Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Application for Support for Access to Major Research Facilities Program - Project title: Structural Studies on PNMT, Mouse Latexin, Insect Ferritin
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Structural studies on carbohydrate modifying enzymes
    ARC Linkage Projects
    Open grant
  • 2003
    Structural Studies on the Regulation of SNARE Proteins by Munc18c
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2005
    Structure, Function And Regulation Of Human Cytosolic Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000
    Chromatography system for structural biology
    Ramaciotti Foundation
    Open grant
  • 2000 - 2002
    Design and development of inhibitors of the dengue virus protease as antiviral agents
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on SNARE proteins involved in insulin action
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on the adrenaline-synthesising enzyme, PNMT
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2000
    Structural determination of the protein folding factor CycY
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1999 - 2003
    Applications of Protein Crystallography in Drug Design
    ARC Australian Senior Research Fellowships
    Open grant
  • 1999
    Expression and crystallization of SNARE proteins from adipocytes
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2001
    Protein Disulfide Exchange and Protein Folding in vivo: Structural Studies of Disulfide Oxidoreductases
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2001
    Structural, Functional and Genetic Characterisation of Human Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 1998
    Plant pyruvate phosphate dikinase and human aryl sulfotransferase 3
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1997
    Structure-function studies on human phenylethanolamine N-methyltransferase
    UQ External Support Enabling Grant
    Open grant
  • 1996 - 1998
    Structural studies on purine phosphoribosyltransferases (PRTases)
    ARC Australian Research Council (Large grants)
    Open grant
  • 1996
    Structure determination by NMR of the disulfide-dithiol exchange protein TcpG
    ARC Australian Research Council (Small grants)
    Open grant
  • 1995 - 1997
    Structural studies on reduced DsbA and DsbA analogues
    ARC Australian Research Council (Large grants)
    Open grant
  • 1994 - 2006
    Design of inhibitors of epinephrine biosynthesis.
    University of Kansas
    Open grant

Availability

Emerita Professor Jenny Martin is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Emerita Professor Jenny Martin directly for media enquiries about:

  • antibacterials
  • Antibiotic discovery
  • antibiotics
  • bacteria
  • bacterial infection
  • Crystallography - protein
  • diabetes
  • drug discovery
  • Enzyme inhibition
  • infection
  • inflammation
  • insulin
  • Protein crystallography
  • Protein function
  • Protein structure
  • Proteins
  • science policy
  • scientific leadership
  • superbugs
  • women in science

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