Overview
Background
My research interests are in the field of Chemistry education, particularly how students learn in the chemistry laboratory.
I teach biological inorganic chemistry at a second and Masters level, as well as a broad range of topics in first year chemistry. I also teach the ethics of chemistry in second year.
Availability
- Dr Philip Sharpe is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Law, The University of Queensland
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy, The University of Queensland
- Member, Royal Australian Chemical Institute, Royal Australian Chemical Institute
Research interests
-
Chemistry education
I am interested in the ways that students learn to communicate Chemistry and how the barriers to effective learning in Chemistry can be reduced. I have a particular interest in learning in the laboratory setting.
Works
Search Professor Philip Sharpe’s works on UQ eSpace
2009
Journal Article
Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors
Yu, Yu, Kalinowski, Danuta S., Kovacevic, Zaklina, Siafakas, Aritee R., Jansson, Patric J., Stefani, Christian, Lovejoy, David B., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2009). Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors. Journal of Medicinal Chemistry, 52 (17), 5271-5294. doi: 10.1021/jm900552r
2009
Journal Article
2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activity
Richardson, Des R., Kalinowski, Danuta S., Richardson, Vera, Sharpe, Philip C., Lovejoy, David B., Islam, Mohammad and Bernhardt, Paul V. (2009). 2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activity. Journal of Medicinal Chemistry, 52 (5), 1459-1470. doi: 10.1021/jm801585u
2009
Journal Article
Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activity
Bernhardt, Paul V., Sharpe, Philip C., Islam, Mohammed, Lovejoy, David B., Kalinowski, Danuta S. and Richardson, Des R. (2009). Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activity. Journal of Medicinal Chemistry, 52 (2), 407-415. doi: 10.1021/jm801012z
2008
Journal Article
Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands
Bernhardt, P.V., Wilson, G.J., Sharpe, P.C., Kalinowski, D.S. and Richardson, D.R. (2008). Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands. Journal of Biological Inorganic Chemistry, 13 (1), 107-119. doi: 10.1007/s00775-007-0300-4
2008
Conference Publication
Chelators as Medicinal Agents: Iron and Beyond
Sharpe, Philip (2008). Chelators as Medicinal Agents: Iron and Beyond. Inorganic Chemistry Conference IC08, Christchurch, New Zealand, 14-18 December 2008.
2008
Journal Article
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone series
Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2008). Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone series. Journal of Medicinal Chemistry, 51 (2), 331-344. doi: 10.1021/jm7012562
2007
Journal Article
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analogues
Kalinowski, DS, Sharpe, PC, Bernhardt, PV and Richardson, DR (2007). Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analogues. Journal of Medicinal Chemistry, 50 (24), 6212-6225. doi: 10.1021/jm070839q
2007
Journal Article
Design, synthesis, and characterization of novel iron chelators: Structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents
Kalinowski, D. S., Yu, Y., Sharpe, P. C., Islam, M., Liao, Y. T., Lovejoy, D. B., Kumar, N., Bernhardt, P. V. and Richardson, D. R. (2007). Design, synthesis, and characterization of novel iron chelators: Structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents. Journal of Medicinal Chemistry, 50 (15), 3716-3729. doi: 10.1021/jm070445z
2007
Journal Article
Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity
Bernhardt, Paul V., Chin, Piao, Sharpe, Philip C. and Richardson, Des R. (2007). Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity. Dalton Transactions, 2007 (30), 3232-3244. doi: 10.1039/b704102k
2007
Book Chapter
Amyloid peptides and proteins in review
Harrison, R. S., Sharpe, P. C., Singh, Y. and Fairlie, D. P. (2007). Amyloid peptides and proteins in review. Reviews of physiology, biochemistry and pharmacology. (pp. 1-77) edited by S. G. Amara, B. Bamberg, T. Fleischmann, S. C. Gudermann, S. C. Hebert, R. Jahn, W. J. Lederer, R. Lill, A. Miyajima, S. Offermanns and R. Zechner. Berlin, Germany: Springer. doi: 10.1007/112_2007_0701
2006
Journal Article
Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity
Richardson, D. R., Sharpe, P. C., Lovejoy, D. B., Senaratne, D., Kalinowski, D. S., Islam, M. and Bernhardt, P. V. (2006). Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. Journal of Medicinal Chemistry, 49 (22), 6510-6521. doi: 10.1021/jm0606342
2006
Conference Publication
Peptide bundles: Loops, helices, strands and sheets
Fairlie, D., Singh, Y. and Sharpe, P. C. (2006). Peptide bundles: Loops, helices, strands and sheets. The American Chemical Society Meeting 2006, Atlanta, GA, USA, 26 -30 March, 2006. Washington: American Chemical Society.
2006
Journal Article
Transition metal complexes as mediator-titrants in protein redox potentiometry
Bernhardt, P. V., Chen, K. I. and Sharpe, P. C. (2006). Transition metal complexes as mediator-titrants in protein redox potentiometry. Journal of Biological Inorganic Chemistry, 11 (7), 930-936. doi: 10.1007/s00775-006-0148-z
2005
Journal Article
Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity
Bernhardt, Paul V., Chin, Piao, Sharpe, Philip C., Wang, Jing-Yan C. and Richardson, Des R. (2005). Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity. Journal of Biological Inorganic Chemistry, 10 (7), 761-777. doi: 10.1007/s00775-005-0018-0
2003
Conference Publication
Template-assembled peptide loops, helices, sheets and nanofibres
Fairlie, DP, Singh, Y, Sharpe, P and Stoermer, M (2003). Template-assembled peptide loops, helices, sheets and nanofibres. 225th National Meeting of the American-Chemical-Society, New Orleans Louisiana, Mar 23-27, 2003. WASHINGTON: AMER CHEMICAL SOC.
2003
Conference Publication
Template-assembled peptide loops, helices, sheets, and nanofibers
Fairlie, David P ., Singh, Yogendra, Sharpe, Philip and Stoermer, Martin (2003). Template-assembled peptide loops, helices, sheets, and nanofibers. 225th ACS National Meeting, New Orleans, LA, United States, 23-27 March 2003.
2002
Journal Article
Copper(II) nitrite complexes of tripodal ligands derived from 1,1,1-tris(2-pyridyl)methylamine
Arnold, Phillip J., Davies, Sian C., Durrant, Marcus C., Griffiths, D. Vaughan, Hughes, David L. and Sharpe, Phillip C. (2002). Copper(II) nitrite complexes of tripodal ligands derived from 1,1,1-tris(2-pyridyl)methylamine. Inorganica Chimica Acta, 348 (5), 143-149. doi: 10.1016/S0020-1693(02)01487-1
2001
Journal Article
Copper complexes of the functionalised tripodal ligand tris(2-pyridyl)methylamine and its derivatives
Arnold, PJ, Davies, SC, Dilworth, , Durrant, MC, Griffiths, DV, Hughes, DL, Richards, RL and Sharpe, PC (2001). Copper complexes of the functionalised tripodal ligand tris(2-pyridyl)methylamine and its derivatives. Journal of the Chemical Society-Dalton Transactions (5), 736-746. doi: 10.1039/b008476j
2000
Journal Article
Structurally reinforced tetraazamacrocyclic complexes
Bernhardt, PV and Sharpe, PC (2000). Structurally reinforced tetraazamacrocyclic complexes. Inorganic Chemistry, 39 (10), 2020-2025. doi: 10.1021/ic9906353
2000
Journal Article
C-substituted macrocycles as candidates for radioimmunotherapy
Bernhardt, PV and Sharpe, PC (2000). C-substituted macrocycles as candidates for radioimmunotherapy. Inorganic Chemistry, 39 (18), 4123-4129. doi: 10.1021/ic000315f
Funding
Past funding
Supervision
Availability
- Dr Philip Sharpe is:
- Available for supervision
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Supervision history
Completed supervision
-
2011
Doctor Philosophy
Tuning the redox potential of conducting polymeric films
Associate Advisor
Other advisors: Professor Paul Bernhardt
-
2009
Doctor Philosophy
Iron chelators in the treatment of cancer
Associate Advisor
Other advisors: Professor Paul Bernhardt
Media
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