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2014 Journal Article Chemistry for the massesSharpe, Philip C. and Blanchfield, Joanne T. (2014). Chemistry for the masses. International Journal of Innovation in Science and Mathematics Education, 22 (4), 33-47. |
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2011 Journal Article Synthetic and natural products as iron chelatorsSharpe, Philip C., Richardson, Des R., Kalinowski, Danuta S. and Bernhardt, Paul V. (2011). Synthetic and natural products as iron chelators. Current Topics in Medicinal Chemistry, 11 (5), 591-607. doi: 10.2174/156802611794785163 |
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2016 Journal Article Novel mechanism of cytotoxicity for the selective selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone (Ap44mSe): lysosomal membrane permeabilizationAl-Eisawi, Zaynab, Stefani, Christian, Jansson, Patric J., Arvind, Akanksha, Sharpe, Philip C., Basha, Maram T., Iskander, George M., Kumar, Naresh, Kovacevic, Zaklina, Lane, Darius J. R., Sahni, Sumit, Bernhardt, Paul V., Richardson, Des R. and Kalinowski, Danuta S. (2016). Novel mechanism of cytotoxicity for the selective selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone (Ap44mSe): lysosomal membrane permeabilization. Journal of Medicinal Chemistry, 59 (1), 294-312. doi: 10.1021/acs.jmedchem.5b01399 |
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2014 Journal Article Electrochemically mediated enantioselective reduction of chiral sulfoxidesChen, Kuan I., Challinor, Victoria L., Kielmann, Linda, Sharpe, Philip C., De Voss, James J., Kappler, Ulrike, McEwan, Alastair G. and Bernhardt, Paul V. (2014). Electrochemically mediated enantioselective reduction of chiral sulfoxides. Journal of Biological Inorganic Chemistry, 20 (2), 395-402. doi: 10.1007/s00775-014-1215-5 |
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2013 Journal Article Planar array of corrugated tapered slot antennas for ultrawideband biomedical microwave imaging systemMohammed, Beada'a J., Abbosh, Amin M. and Sharpe, Philip (2013). Planar array of corrugated tapered slot antennas for ultrawideband biomedical microwave imaging system. International Journal of RF and Microwave Computer-Aided Engineering, 23 (1), 59-66. doi: 10.1002/mmce.20651 |
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2012 Journal Article Novel second-generation Di-2-Pyridylketone Thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivoLovejoy, David B., Sharp, Danae M., Seebacher, Nicole, Obeidy, Peyman, Prichard, Thomas, Stefani, Christian, Basha, Maram T., Sharpe, Philip C., Jansson, Patric J., Kalinowski, Danuta S., Bernhardt, Paul V. and Richardson, Des R. (2012). Novel second-generation Di-2-Pyridylketone Thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. Journal of Medicinal Chemistry, 55 (16), 7230-7244. doi: 10.1021/jm300768u |
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2012 Journal Article Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effectQuach, Patricia, Gutierrez, Elaine, Basha, Maram Talal, Kalinowski, Danuta S., Sharpe, Philip C., Lovejoy, David B., Bernhardt, Paul V., Jansson, Patric J. and Richardson, Des R. (2012). Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect. Molecular Pharmacology, 82 (1), 105-114. doi: 10.1124/mol.112.078964 |
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2011 Journal Article Halogenated 2′-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: Relationship to intracellular redox activityStefani, Christian, Punnia-Moorthy, Gaya, Lovejoy, David B., Jansson, Patric J., Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2011). Halogenated 2′-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: Relationship to intracellular redox activity. Journal of Medicinal Chemistry, 54 (19), 6936-6948. doi: 10.1021/jm200924c |
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2011 Journal Article Heterogeneous breast phantom for ultra wideband microwave imagingAbu Bakar, A, Abbosh, A, Sharpe, P, Bialkowski, ME and Wang, YF (2011). Heterogeneous breast phantom for ultra wideband microwave imaging. Microwave and Optical Technology Letters, 53 (7), 1595-1598. doi: 10.1002/mop.26046 |
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2011 Journal Article The medicinal chemistry of novel iron chelators for the treatment of cancerKovacevic, Zaklina, Kalinowski, Danuta S., Lovejoy, David B., Yu, Yu, Rahmanto, Yohan Suryo, Sharpe, Phillip C., Bernhardt, Paul V. and Richardson, Des R. (2011). The medicinal chemistry of novel iron chelators for the treatment of cancer. Current Topics in Medicinal Chemistry, 11 (5), 483-499. doi: 10.2174/156802611794785190 |
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2011 Journal Article Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregatesSingh, Yogendra, Sharpe, Philip C., Hoang, Huy N., Lucke, Andrew J., McDowall, Alasdair W., Bottomley, Stephen P. and Fairlie, David P. (2011). Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregates. Chemistry: A European Journal, 17 (1), 151-160. doi: 10.1002/chem.201002500 |
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2010 Journal Article Novel thiosemicarbazones of the ApT and DpT Series and their copper complexes: Identification of pronounced redox activity and characterization of their antitumor activityJansson, Patric J., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2010). Novel thiosemicarbazones of the ApT and DpT Series and their copper complexes: Identification of pronounced redox activity and characterization of their antitumor activity. Journal of Medicinal Chemistry, 53 (15), 5759-5769. doi: 10.1021/jm100561b |
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2009 Journal Article Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitorsYu, Yu, Kalinowski, Danuta S., Kovacevic, Zaklina, Siafakas, Aritee R., Jansson, Patric J., Stefani, Christian, Lovejoy, David B., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2009). Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors. Journal of Medicinal Chemistry, 52 (17), 5271-5294. doi: 10.1021/jm900552r |
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2009 Journal Article 2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activityRichardson, Des R., Kalinowski, Danuta S., Richardson, Vera, Sharpe, Philip C., Lovejoy, David B., Islam, Mohammad and Bernhardt, Paul V. (2009). 2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activity. Journal of Medicinal Chemistry, 52 (5), 1459-1470. doi: 10.1021/jm801585u |
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2009 Journal Article Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activityBernhardt, Paul V., Sharpe, Philip C., Islam, Mohammed, Lovejoy, David B., Kalinowski, Danuta S. and Richardson, Des R. (2009). Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activity. Journal of Medicinal Chemistry, 52 (2), 407-415. doi: 10.1021/jm801012z |
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2008 Journal Article Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone seriesKalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2008). Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone series. Journal of Medicinal Chemistry, 51 (2), 331-344. doi: 10.1021/jm7012562 |
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2008 Journal Article Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligandsBernhardt, P.V., Wilson, G.J., Sharpe, P.C., Kalinowski, D.S. and Richardson, D.R. (2008). Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands. Journal of Biological Inorganic Chemistry, 13 (1), 107-119. doi: 10.1007/s00775-007-0300-4 |
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2007 Journal Article Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analoguesKalinowski, DS, Sharpe, PC, Bernhardt, PV and Richardson, DR (2007). Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analogues. Journal of Medicinal Chemistry, 50 (24), 6212-6225. doi: 10.1021/jm070839q |
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2007 Journal Article Design, synthesis, and characterization of novel iron chelators: Structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agentsKalinowski, D. S., Yu, Y., Sharpe, P. C., Islam, M., Liao, Y. T., Lovejoy, D. B., Kumar, N., Bernhardt, P. V. and Richardson, D. R. (2007). Design, synthesis, and characterization of novel iron chelators: Structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents. Journal of Medicinal Chemistry, 50 (15), 3716-3729. doi: 10.1021/jm070445z |
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2007 Journal Article Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activityBernhardt, Paul V., Chin, Piao, Sharpe, Philip C. and Richardson, Des R. (2007). Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity. Dalton Transactions, 2007 (30), 3232-3244. doi: 10.1039/b704102k |
