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Professor Elizabeth Powell
Professor

Elizabeth Powell

Email: 
Phone: 
+61 7 344 38015

Overview

Background

NAME Professor Elizabeth Ellen POWELL

POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital

Email e.powell@uq.edu.au

EDUCATION/TRAINING

Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland

Fellow of the Royal Australasian College of Physicians

Doctor of Philosophy (PhD), The University of Queensland

Fellow of the Royal College of Physicians, London

Fellow, American Association for the Study of Liver Diseases

Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.

Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:

(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.

(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)

(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease

Availability

Professor Elizabeth Powell is:
Available for supervision

Fields of research

Research impacts

Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.

Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.

Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.

Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.

International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.

Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.

Works

Search Professor Elizabeth Powell’s works on UQ eSpace

303 works between 1984 and 2025

121 - 140 of 303 works

2015

Journal Article

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

2015

Conference Publication

An exploratory study into the unmet supportive needs of people diagnosed with cirrhosis in Queensland, Australia

Valery, P. C., Clark, P. J., Mcphail, S. M., Martin, J., Horsfall, L., Volk, M. L. and Powell, E. (2015). An exploratory study into the unmet supportive needs of people diagnosed with cirrhosis in Queensland, Australia. HOBOKEN: WILEY-BLACKWELL.

An exploratory study into the unmet supportive needs of people diagnosed with cirrhosis in Queensland, Australia

2015

Journal Article

The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease

Irvine, Katharine M., Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin J., Horsfall, Leigh U., Fletcher, Linda M., Ungerer, Jacobus P. J., Pretorius, Carel J., Miller, Gregory C., Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease. Liver International, 36 (3), 370-377. doi: 10.1111/liv.12896

The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease

2015

Journal Article

Response to ELF cut-off points: aetiology is also a relevant factor

Powell, Elizabeth E., Irvine, Katharine M., Fagan, Kevin J., Ballard, Emma and O'Rourke, Peter (2015). Response to ELF cut-off points: aetiology is also a relevant factor. Liver International, 35 (7), 1921-1921. doi: 10.1111/liv.12822

Response to ELF cut-off points: aetiology is also a relevant factor

2015

Journal Article

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

Fagan, Kevin J., Pretorius, Carel J., Horsfall, Leigh U., Irvine, Katharine M., Wilgen, Urs, Choi, Kihoon, Fletcher, Linda M., Tate, Jill, Melino, Michelle, Nusrat, Sharmin, Miller, Gregory C., Clouston, Andrew D., Ballard, Emma, O'Rourke, Peter, Lampe, Guy, Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2015). ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. Liver International, 35 (6), 1673-1681. doi: 10.1111/liv.12760

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

2015

Journal Article

Systematic review: unmet supportive care needs in people diagnosed with chronic liver disease

Valery, Patricia C., Powell, Elizabeth, Moses, Neta, Volk, Michael L., McPhail, Steven M., Clark, Paul J. and Martin, Jennifer (2015). Systematic review: unmet supportive care needs in people diagnosed with chronic liver disease. BMJ Open, 5 (4) e007451, 1-16. doi: 10.1136/bmjopen-2014-007451

Systematic review: unmet supportive care needs in people diagnosed with chronic liver disease

2015

Journal Article

Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection

Fagan, Kevin J., Rogers, Geraint B., Melino, Michelle, Arthur, Dionne M., Costello, Mary-Ellen, Morrison, Mark, Powell, Elizabeth E. and Irvine, Katharine M. (2015). Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection. PLoS One, 10 (3) e0120642, e0120642. doi: 10.1371/journal.pone.0120642

Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection

2015

Journal Article

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Eslam, Mohammed, Hashem, Ahmed M, Leung, Reynold, Romero-Gomez, Manuel, Berg, Thomas, Dore, Gregory J, Chan, Henry L.K, Irving, William L, Sheridan, David, Abate, Maria L, Adams, Leon A, Mangia, Alessandra, Weltman, Martin, Bugianesi, Elisabetta, Spengler, Ulrich, Shaker, Olfat, Fischer, Janett, Mollison, Lindsay, Cheng, Wendy, Powell, Elizabeth, Nattermann, Jacob, Riordan, Stephen, McLeod, Duncan, Armstrong, Nicola J, Douglas, Mark W, Liddle, Christopher, Booth, David R, George, Jacob, Ahlenstiel, Golo ... Santaro, Rosanna (2015). Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nature Communications, 6 (6422) 6422. doi: 10.1038/ncomms7422

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

2015

Conference Publication

Discrepancies in the use of medications in patients with cirrhosis

Hayward, K., Valery, P. C., Cottrell, N., Irvine, K., Horsfall, L., Ruffin, B., Tallis, C., Chachay, V., Martin, J. and Powell, E. (2015). Discrepancies in the use of medications in patients with cirrhosis. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD Australia, 28 September - 2 October 2015. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/jgh.13093

Discrepancies in the use of medications in patients with cirrhosis

2015

Conference Publication

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

Irvine, K. M., Wockner, L. F., Shanker, M., Fagan, K. J., Horsfall, L. U., Fletcher, L. M., Ungerer, J., Pretorius, C. J., Miller, G. C., Clouston, A. D., Lampe, G. and Powell, E. E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

2015

Conference Publication

Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation

Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087

Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation

2015

Conference Publication

Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.

Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury

2015

Conference Publication

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

Irvine, Katharine, Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin, Horsfall, Leigh, Fletcher, Linda, Ungerer, Jacobus, Pretorius, Carel J., Miller, Gregory, Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, United States, 13-17 November 2015. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/hep.28218

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

2015

Conference Publication

Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease

El-Atem, N., Wojcik, K., Horsfall, L., Irvine, K., Johnson, T., Mcphail, S. M. and Powell, E. E. (2015). Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease

2015

Conference Publication

Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal

Mcphail, S. M., Horsfall, L., Irvine, K., Fagan, K. J. and Powell, E. E. (2015). Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal

2014

Journal Article

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Irvine, Katharine M., Skoien, Richard, Bokil, Nilesh J., Melino, Michelle, Thomas, Gethin P., Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M., Sweet, Matthew J., Clouston, Andrew D. and Powell, Elizabeth E. (2014). Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration. World Journal of Gastroenterology, 20 (47), 17851-17862. doi: 10.3748/wjg.v20.i47.17851

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

2014

Conference Publication

An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease

Fagan, K., Horsfall, L., Irvine, K., Fletcher, L., Tate, J., Choi, K., Nusrat, S., Melino, M., Clouston, A., Ballard, E., O'Rourke, P., Lampe, G., Ungerer, J. and Powell, E. (2014). An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease. Australian Gastroenterology Week 2014, UnknownGold Coast Convention & Exhibition Centre, Broadbeach, Queensland, 22-24 October. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease

2014

Journal Article

Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?

Fagan, K. J., Zhao, Eileen Y., Horsfall, L. U., Ruffin, Brittany J., Kruger, Mark S., McPhail, S. M., O'Rourke, Peter, Ballard, Emma, Irvine, K. M. and Powell, E. E. (2014). Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?. Internal Medicine Journal, 44 (9), 865-872. doi: 10.1111/imj.12491

Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?

2014

Journal Article

Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers

Fagan K.J., Irvine K.M., McWhinney B.C., Fletcher L.M., Horsfall L.U., Johnson L., O'Rourke P., Martin J., Scott I., Pretorius C.J., Ungerer J.P.J. and Powell E.E. (2014). Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterology, 14 (1) 97, 1-6. doi: 10.1186/1471-230X-14-97

Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers

2014

Journal Article

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

Gadd, Victoria L., Skoien, Richard, Powell, Elizabeth E., Fagan, Kevin J., Winterford, Clay, Horsfall, Leigh, Irvine, Katharine and Clouston, Andrew D. (2014). The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology, 59 (4), 1393-1405. doi: 10.1002/hep.26937

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

Funding

Past funding

  • 2019 - 2020
    ELF Study (Siemens - Unrestricted Education Grant)
    Siemens Healthcare Pty Ltd
    Open grant
  • 2017 - 2020
    HLA-G/H2-Bl is Critical for Regulating Inflammation in the Liver
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    MERTK receptor tyrosine kinase: A novel therapeutic target for liver fibrosis (NHMRC Project Grant administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2015 - 2017
    Non-invasive assessment of Hepatic Steatosis (Fibrosis) by Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)
    CSIRO
    Open grant
  • 2015 - 2017
    Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
    Siemens Ltd
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    High throughput gene expression of patient samples via the Nanostring nCounter system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    Targeting the Wnt Pathway: Implication for Chronic Liver disease
    PA Research Foundation
    Open grant
  • 2013 - 2015
    Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Monocytes/macrophages in chronic liver diseases: cross-talk with hepatocytes and nonparenchymal cells and role in progressive liver injury
    NHMRC Project Grant
    Open grant
  • 2011 - 2015
    NHMRC Practitioner Fellowship: The role of obesity, insulin resistance and fatty liver (steatosis) in human disease and strategies to monitor and improve patient outcomes
    NHMRC Practitioner Fellowship
    Open grant
  • 2009 - 2012
    Mayne Bequest Fund Research Support Award: Investigation of mechanisms contributing to disease progression and response to treatment in chronic liver diseases
    Mayne Bequest Fund
    Open grant
  • 2008 - 2010
    Role of obesity in impaired treatment response in chronic hepatitis C: mechanisms and therapeutic strategies
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Hepatocyte replicative arrest, hepatic progenitor cells and the ductular reaction in hepatic fibrogenesis
    NHMRC Project Grant
    Open grant
  • 2007
    Non-invasive assessment of hepatic steatosis by magnetic resonance imaging (MRI and spectroscopy (MRS)
    PA Research Foundation
    Open grant
  • 2006
    Effect of weight loss on SOC-3 expression and response to antiviral therapy in patients with chronic hepatitis C
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2006 - 2010
    NHMRC Practitioner Fellowship
    NHMRC Practitioner Fellowship
    Open grant
  • 2006 - 2008
    UQ Postdoctoral Fellowship 2006 - Scott Ward - HS Faculty contribution
    Mayne Bequest Fund
    Open grant
  • 2005
    The effect of obesity on liver function in children who are long term liver transplant recipients
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2007
    The role of steatosis in promoting cellular injury and fibrogenesis in human liver disease
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    Role of magnetic resonance imaging in monitoring hepatic steatosis and visceral adiposity during treatment.
    Wesley Merdical Research
    Open grant
  • 2004 - 2005
    Genetic factors and hepatitis C - role in predicting disease progression
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2004 - 2005
    The Effect Of Alcohol On Hepatitis C-Induced Liver Disease
    Australian Brewers' Foundation
    Open grant
  • 2003 - 2004
    PAHF block funding
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant

Supervision

Availability

Professor Elizabeth Powell is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)

    Principal Advisor

  • Doctor Philosophy

    Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)

    Principal Advisor

Completed supervision

Media

Enquiries

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