![Dr Lotten Ragnarsson](/sites/default/files/profiles/912.jpeg)
Overview
Availability
- Dr Lotten Ragnarsson is:
- Available for supervision
Fields of research
Qualifications
- Masters (Research) of Science, University of Kalmar
- Licentiate of Immunology, unknown
- Doctor of Philosophy of Biochemistry and Molecular Biology, The University of Queensland
Works
Search Professor Lotten Ragnarsson’s works on UQ eSpace
2024
Journal Article
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain
Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain. International Journal of Molecular Sciences, 25 (9) 4745, 4745. doi: 10.3390/ijms25094745
2024
Journal Article
Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)
Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152
2023
Journal Article
GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms
Ragnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776
2023
Journal Article
Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH
Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664
2023
Journal Article
Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific
Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135
2023
Journal Article
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
2023
Book Chapter
Role of Ionotropic Glutamate receptors in neurodegenerative and other disorders
Ragnarsson, Lotten, Dodd, Peter R. and Latif, Matthew R. (2023). Role of Ionotropic Glutamate receptors in neurodegenerative and other disorders. Handbook of neurotoxicity. (pp. 1969-1997) edited by Richard M. Kostrzewa. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-15080-7_144
2022
Journal Article
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
2022
Journal Article
Diindolylmethane derivatives: new selective blockers for T-type calcium channels
Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749
2022
Journal Article
The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>
Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923
2022
Journal Article
Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation
Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013
2022
Journal Article
The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation
Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570
2021
Journal Article
Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain
Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645
2021
Conference Publication
Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2
Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.
2020
Journal Article
Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator
Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343
2020
Journal Article
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors
Mohan, Madhan Kumar, Abraham, Nikita, Rajesh, R. P., Jayaseelan, Benjamin Franklin, Ragnarsson, Lotten, Lewis, Richard J. and Sarma, Siddhartha P. (2020). Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295 (20), 7096-7112. doi: 10.1074/jbc.RA119.012098
2020
Journal Article
Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris
Giribaldi, Julien, Ragnarsson, Lotten, Pujante, Tom, Enjalbal, Christine, Wilson, David, Daly, Norelle L., Lewis, Richard J. and Dutertre, Sebastien (2020). Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris. Marine Drugs, 18 (3) md18030150, 150. doi: 10.3390/md18030150
2020
Journal Article
Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter
Jha, Prerna, Ragnarsson, Lotten and Lewis, Richard J. (2020). Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter. Frontiers in Pharmacology, 11 217, 217. doi: 10.3389/fphar.2020.00217
2020
Journal Article
The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein
Scheib, Holger, Nekaris, K. Anne-Isola, Rode-Margono, Johanna, Ragnarsson, Lotten, Baumann, Kate, Dobson, James S., Wirdateti, Wirdateti, Nouwens, Amanda, Nijman, Vincent, Martelli, Paolo, Ma, Rui, Lewis, Richard J., Kwok, Hang Fai and Fry, Bryan Grieg (2020). The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein. Toxins, 12 (2) toxins12020086, 86. doi: 10.3390/toxins12020086
2020
Conference Publication
Re-evaluating the nirvana cabal deployed by piscivorous cone snails
Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Asa, Brust, Andreas, Deakan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2020). Re-evaluating the nirvana cabal deployed by piscivorous cone snails. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.044
Supervision
Availability
- Dr Lotten Ragnarsson is:
- Available for supervision
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Supervision history
Completed supervision
-
2020
Doctor Philosophy
Discovery and Characterisation of Venom Peptide and Small Molecule Modulators for T-type Calcium Channels
Associate Advisor
Other advisors: Professor Richard Lewis
-
2018
Doctor Philosophy
Applying the conopeptide discovery pipeline to reveal the venom peptide complexity of the piscivorous cone snail, Conus tulipa
Associate Advisor
Other advisors: Professor Richard Lewis
-
2016
Doctor Philosophy
Structure-function studies of norepinephrine and the allosteric inhibitor Chi-MrIA at the human norepinephrine transporter
Associate Advisor
Other advisors: Professor Richard Lewis
-
2016
Doctor Philosophy
Investigating nAChR structure and function using AChBP and alpha-conotoxins.
Associate Advisor
Other advisors: Professor Richard Lewis
-
2014
Doctor Philosophy
Discovery and Characterisation of Novel Analgesic Neurotoxins, hCav2.2 Channel inhibitors, from Cone Snail and Spider Venoms
Associate Advisor
Other advisors: Professor Richard Lewis, Professor Irina Vetter
-
Master Philosophy
Characterisation of the Alpha1B-Adrenoceptor by Modeling, Dynamics and Virtual Screening
Associate Advisor
Other advisors: Professor Richard Lewis
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