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2016 Journal Article Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assayAzimi, Iman, Flanagan, Jack U., Stevenson, Ralph J., Inserra, Marco, Vetter, Irina, Monteith, Gregory R. and Denny, William A. (2016). Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry, 25 (1), 440-449. doi: 10.1016/j.bmc.2016.11.007 |
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2015 Journal Article Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2Bugarcic, Andrea, Vetter, Irina, Chalmers, Silke, Kinna, Genevieve, Collins, Brett M. and Teasdale, Rohan D. (2015). Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biology International, 39 (11), 1299-1306. doi: 10.1002/cbin.10508 |
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2015 Journal Article Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesiaDeuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113 |
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2015 Journal Article Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catusHimaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015). Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 (10), 4372-4381. doi: 10.1021/acs.jproteome.5b00630 |
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2015 Journal Article Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriensCardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178 |
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2015 Journal Article (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptorPaz, Cristian, Becerra, Jose, Silva, Mario, Burgos, Viviana, Heydenreich, Matthias, Schmidt, Bernd, Thu Tran and Vetter, Irina (2015). (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor. Natural Product Communications, 10 (8), 1355-1357. doi: 10.1177/1934578x1501000810 |
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2015 Journal Article δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snailsJin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015). δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 (1811) 20150817, 1-8. doi: 10.1098/rspb.2015.0817 |
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2015 Journal Article Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approachKlint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081 |
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2015 Journal Article Inhibition of N-type calcium channels by fluorophenoxyanilide derivativesGleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2015). Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs, 13 (4), 2030-2045. doi: 10.3390/md13042030 |
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2015 Journal Article α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptorsMueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011 |
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2015 Journal Article A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesColl, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806 |
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2015 Journal Article Therapeutic opportunities for targeting cold pain pathwaysYin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015). Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 (2), 125-140. doi: 10.1016/j.bcp.2014.09.024 |
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2015 Journal Article Vergiftung durch Tropenfisch: Ciguatera-Epidemie in DeutschlandZimmermann, Katharina, Eisenblätte, Anneka, Vetter, Irina, Ebbecke, Martin, Friedemann, Miriam and Desel, Herbert (2015). Vergiftung durch Tropenfisch: Ciguatera-Epidemie in Deutschland. Deutsche Medizinische Wochenschrift, 140 (2), 125-130. doi: 10.1055/s-0040-100439 |
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2015 Journal Article Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venomJin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015). Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 (23-24), 4030-4040. doi: 10.1002/pmic.201500220 |
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2015 Journal Article α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptorsWan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244 |
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2015 Journal Article Feeling hot, feeling cold: TRP channels - a great story unfoldsVetter, Irina, Kym, Philip R. and Szallasi, Arpad (2015). Feeling hot, feeling cold: TRP channels - a great story unfolds. Temperature, 2 (2), 150-151. doi: 10.1080/23328940.2015.1047721 |
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2014 Journal Article Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligandsMollica, Adriano, Costante, Roberto, Novellino, Ettore, Stefanucci, Azzurra, Pieretti, Stefano, Zador, Ferenc, Samavati, Reza, Borsodi, Anna, Benyhe, Sandor, Vetter, Irina and Lewis, Richard J. (2014). Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands. Chemical Biology and Drug Design, 86 (2), 156-162. doi: 10.1111/cbdd.12479 |
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2014 Journal Article Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countriesMattei, Cesar, Vetter, Irina, Eisenblatter, Anneka, Krock, Bernd, Ebbecke, Martin, Desel, Herbert and Zimmermann, Katharina (2014). Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries. Toxicon, 91 (2), 76-83. doi: 10.1016/j.toxicon.2014.10.016 |
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2014 Journal Article No gain, no pain: NaV1.7 as an analgesic targetKing, Glenn F and Vetter, Irina (2014). No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience, Articles ASAP (9), 749-751. doi: 10.1021/cn500171p |
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2014 Journal Article 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.Karas, John A., Scanlon, Denis B., Forbes, Briony E., Vetter, Irina, Lewis, Richard J., Gardiner, James, Separovic, Frances, Wade, John D. and Hossain, Mohammed A. (2014). 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.. Chemistry: A European Journal, 20 (31), 9549-9552. doi: 10.1002/chem.201403574 |
