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2018

Journal Article

Transcriptomics in pain research: insights from new and old technologies

Starobova, H., S. W. A., Himaya, Lewis, R. J. and Vetter, I. (2018). Transcriptomics in pain research: insights from new and old technologies. Molecular Omics, 14 (6), 389-404. doi: 10.1039/c8mo00181b

Transcriptomics in pain research: insights from new and old technologies

2018

Journal Article

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

2018

Journal Article

Data descriptor: chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor

Bicknell, Brendan A., Pujic, Zac, Feldner, Julia, Vetter, Irina and Goodhill, Geoffrey J. (2018). Data descriptor: chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor. Scientific Data, 5 (1) 180183, 180183. doi: 10.1038/sdata.2018.183

Data descriptor: chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor

2018

Journal Article

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family

Robinson, Samuel D., Mueller, Alexander, Clayton, Daniel, Starobova, Hana, Hamilton, Brett R., Payne, Richard J., Vetter, Irina, King, Glenn F. and Undheim, Eivind A. B. (2018). A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family. Science Advances, 4 (9) eaau4640, eaau4640. doi: 10.1126/sciadv.aau4640

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family

2018

Conference Publication

Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice

Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., Lewis, R., King, G. and Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. HOBOKEN: WILEY.

Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice

2018

Journal Article

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

Stevenson, Ralph J, Azimi, Iman, Flanagan, Jack U, Inserra, Marco, Vetter, Irina, Monteith, Gregory R and Denny, William A (2018). An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay. Bioorganic & Medicinal Chemistry, 26 (12), 3406-3413. doi: 10.1016/j.bmc.2018.05.012

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

2018

Journal Article

The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain

Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495

The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain

2018

Journal Article

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels

Yapa, Kunsala T. D. S., Deuis, Jennifer, Peters, Amelia A., Kenny, Paraic A., Roberts-Thomson, Sarah J., Vetter, Irina and Monteith, Gregory R. (2018). Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sciences, 198, 128-135. doi: 10.1016/j.lfs.2018.02.030

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels

2018

Journal Article

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain

Morgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain

2018

Journal Article

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

Israel, Mathilde R., Thongyoo, Panumart, Deuis, Jennifer R., Craik, David J., Vetter, Irina and Durek, Thomas (2018). The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6. Journal of Medicinal Chemistry, 61 (4), 1730-1736. doi: 10.1021/acs.jmedchem.7b01609

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

2018

Conference Publication

Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation

Ferraz, C. R., Cardos, F. C., Clissa, P. B., Vetter, I., Verri Jr, W. A. and Lewis, R. J. (2018). Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation

2018

Conference Publication

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

Schroeder, Christina, Agwa, Akello, Mueller, Alexander, Chow, Chun Yuen, Peigneur, Steve, Lawrence, Nicole, Deplazes, Evelyne, Mark, Alan, Craik, David, Tytgat, Jan, King, Glenn, Vetter, Irina and Henriques, Sonia Troeira (2018). The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

2018

Journal Article

Pain-causing venom peptides: insights into sensory neuron pharmacology

Jami, Sina, Erickson, Andelain, Brierley, Stuart M and Vetter, Irina (2018). Pain-causing venom peptides: insights into sensory neuron pharmacology. Toxins, 10 (1) 15, 15. doi: 10.3390/toxins10010015

Pain-causing venom peptides: insights into sensory neuron pharmacology

2017

Journal Article

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

2017

Journal Article

Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie, 129 (47), 15169-15172. doi: 10.1002/ange.201708927

Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity

2017

Journal Article

Toxins in neurobiology: new tools from old molecules

Vetter, Irina (2017). Toxins in neurobiology: new tools from old molecules. Neuroscience Letters, 679, 1-3. doi: 10.1016/j.neulet.2017.11.002

Toxins in neurobiology: new tools from old molecules

2017

Journal Article

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity. Angewandte Chemie (International ed. in English), 56 (47), 14973-14976. doi: 10.1002/anie.201708927

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

2017

Journal Article

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

2017

Journal Article

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

2017

Journal Article

Methods used to evaluate pain behaviors in rodents

Deuis, Jennifer R., Dvorakova, Lucie S. and Vetter, Irina (2017). Methods used to evaluate pain behaviors in rodents. Frontiers in Molecular Neuroscience, 10 284, 284. doi: 10.3389/fnmol.2017.00284

Methods used to evaluate pain behaviors in rodents