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2024 Journal Article The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axisHolley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012 |
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2024 Journal Article Mechanistic insights from inflammasome structuresFu, Jianing, Schroder, Kate and Wu, Hao (2024). Mechanistic insights from inflammasome structures. Nature Reviews Immunology, 24 (7), 518-535. doi: 10.1038/s41577-024-00995-w |
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2024 Journal Article Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophagesThygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515 |
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2024 Journal Article NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasomeCoombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145 |
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2024 Journal Article Publisher Correction:: Inflammasome components as new therapeutic targets in inflammatory disease (Nature Reviews Immunology, (2024), 10.1038/s41577-024-01075-9)Coll, Rebecca C. and Schroder, Kate (2024). Publisher Correction:: Inflammasome components as new therapeutic targets in inflammatory disease (Nature Reviews Immunology, (2024), 10.1038/s41577-024-01075-9). Nature Reviews Immunology, 25 (2), 153-153. doi: 10.1038/s41577-024-01122-5 |
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2024 Journal Article Pyroptotic corpses are flagged by filopodia to alert dendritic cellsMonteleone, Mercedes and Schroder, Kate (2024). Pyroptotic corpses are flagged by filopodia to alert dendritic cells. Nature Immunology, 26 (1), 11-12. doi: 10.1038/s41590-024-02025-2 |
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2023 Journal Article Oxidized thioredoxin 1 places a leash on <scp>NLRP1</scp> inflammasome activityYap, Jeremy KY, Emming, Stefan and Schroder, Kate (2023). Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity. Immunology & Cell Biology, 102 (1), 5-7. doi: 10.1111/imcb.12710 |
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2023 Journal Article Apical extrusion prevents apoptosis from activating an acute inflammatory program in epitheliaDuszyc, Kinga, von Pein, Jessica B., Ramnath, Divya, Currin-Ross, Denni, Verma, Suzie, Lim, Fayth, Sweet, Matthew J., Schroder, Kate and Yap, Alpha S. (2023). Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia. Developmental Cell, 58 (21), 2235-2248.e6. doi: 10.1016/j.devcel.2023.08.009 |
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2023 Journal Article Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzymeChan, Amy H., Burgener, Sabrina S., Vezyrgiannis, Kassandra, Wang, Xiaohui, Acklam, Jadie, Von Pein, Jessica B., Pizzuto, Malvina, Labzin, Larisa I., Boucher, Dave and Schroder, Kate (2023). Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme. Life Science Alliance, 6 (10) e202301908, 1-11. doi: 10.26508/lsa.202301908 |
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2023 Journal Article Reversing the mitochondrial hex that bewitches NLRP3Mellacheruvu, Manasa, Lawrence, Grace M. E. P., Emming, Stefan and Schroder, Kate (2023). Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology, 8 (84) eadh2967, 1-4. doi: 10.1126/sciimmunol.adh2967 |
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2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
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2023 Journal Article Apoptotic cell death in disease—Current understanding of the NCCD 2023Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph ... Galluzzi, Lorenzo (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30 (5), 1097-1154. doi: 10.1038/s41418-023-01153-w |
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2023 Journal Article Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion releaseLabzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366 |
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2023 Journal Article Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?Afroz, Syeda Farhana, Raven, Karoline D, Lawrence, Grace M. E. P., Kapetanovic, Ronan, Schroder, Kate and Sweet, Matthew J. (2023). Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?. Biochemical Society. Transactions, 51 (1), 41-56. doi: 10.1042/bst20220014 |
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2023 Journal Article Stoking inflammasome fires in the COVID-19 neighborhoodLabzin, Larisa I. and Schroder, Kate (2023). Stoking inflammasome fires in the COVID-19 neighborhood. Cell Host and Microbe, 31 (2), 168-170. doi: 10.1016/j.chom.2023.01.008 |
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2023 Journal Article HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophagesDas Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120 |
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2022 Journal Article Parkinson's disease: connecting mitochondria to inflammasomesLawrence, Grace M.E.P., Holley, Caroline L. and Schroder, Kate (2022). Parkinson's disease: connecting mitochondria to inflammasomes. Trends in Immunology, 43 (11), 877-885. doi: 10.1016/j.it.2022.09.010 |
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2022 Journal Article Come on mtDNA, light my fireLawrence, Grace M.E.P., Holley, Caroline L. and Schroder, Kate (2022). Come on mtDNA, light my fire. Immunity, 55 (8), 1331-1333. doi: 10.1016/j.immuni.2022.07.011 |
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2022 Journal Article Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analysesMilner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295 |
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2022 Journal Article Inflammasomes and the IL-1 family in bone homeostasis and diseaseTseng, Hsu-Wen, Samuel, Selwin Gabriel, Schroder, Kate, Lévesque, Jean-Pierre and Alexander, Kylie A (2022). Inflammasomes and the IL-1 family in bone homeostasis and disease. Current Osteoporosis Reports, 20 (3), 170-185. doi: 10.1007/s11914-022-00729-8 |
