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2019 Journal Article Inflammasome signaling and regulation of interleukin-1 family cytokinesChan, Amy H. and Schroder, Kate (2019). Inflammasome signaling and regulation of interleukin-1 family cytokines. The Journal of Experimental Medicine, 217 (1) ARTN e20190314, jem.20190314. doi: 10.1084/jem.20190314 |
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2019 Journal Article Tiered DNA sensors for escalating responsesEmming, Stefan and Schroder, Kate (2019). Tiered DNA sensors for escalating responses. Science, 365 (6460), 1375-1376. doi: 10.1126/science.aay2701 |
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2019 Journal Article MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionColl, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7 |
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2018 Journal Article Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsChen, Kaiwen W., Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D., von Pein, Jessica B., Broz, Petr, Sweet, Matthew J. and Schroder, Kate (2018). Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Science Immunology, 3 (26) eaar6676, eaar6676. doi: 10.1126/sciimmunol.aar6676 |
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2018 Journal Article Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionMonteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027 |
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2018 Journal Article Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityBoucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222 |
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2015 Journal Article NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655 |
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2015 Journal Article A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesColl, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806 |
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2014 Journal Article The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella ChallengeChen, Kaiwen W., Groß, Christina J., Vasquez Sotomayor, Flor, Stacey, Katryn J., Tschopp, Jurg, Sweet, Matthew J. and Schroder, Kate (2014). The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge. Cell Reports, 8 (2), 570-582. doi: 10.1016/j.celrep.2014.06.028 |
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Featured 2012 Journal Article Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesSchroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109 |
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2010 Journal Article The inflammasomesSchroder, Kate and Tschopp, Jurg (2010). The inflammasomes. Cell, 140 (6), 821-832. doi: 10.1016/j.cell.2010.01.040 |
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2010 Journal Article NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?Tschopp, Jurg and Schroder, Kate (2010). NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?. Nature Reviews Immunology, 10 (3), 210-215. doi: 10.1038/nri2725 |
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2010 Journal Article The NLRP3 inflammasome: a sensor for metabolic danger?Schroder, Kate, Zhou, Rongbin and Tschopp, Jurg (2010). The NLRP3 inflammasome: a sensor for metabolic danger?. Science, 327 (5963), 269-300. doi: 10.1126/science.1184003 |
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2004 Journal Article Interferon-gamma: an overview of signals, mechanisms and functionsSchroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004). Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 (2), 163-189. doi: 10.1189/jlb.0603252 |
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2024 Journal Article Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cellsHolley, Caroline L., Monteleone, Mercedes, Fisch, Daniel, Libert, Alexandre E. S., Ju, Robert J., Choi, Joon H., Condon, Nicholas D., Emming, Stefan, Crawford, Joanna, Lawrence, Grace M. E. P., Coombs, Jared R., Lefevre, James G., Bajracharya, Rinie, Lahoud, Mireille H., Yap, Alpha S., Hamilton, Nicholas, Stehbens, Samantha J., Kagan, Jonathan C., Ariotti, Nicholas, Burgener, Sabrina S. and Schroder, Kate (2024). Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology, 1-35. doi: 10.1038/s41590-024-02024-3 |
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2024 Journal Article Ornithine lipid is a partial TLR4 agonist and NLRP3 activatorPizzuto, Malvina, Hurtado-Navarro, Laura, Molina-Lopez, Cristina, Soubhye, Jalal, Gelbcke, Michel, Rodriguez-Lopez, Silvia, Ruysschaert, Jean-Marie, Schroder, Kate and Pelegrin, Pablo (2024). Ornithine lipid is a partial TLR4 agonist and NLRP3 activator. Cell Reports, 43 (10) 114788, 114788. doi: 10.1016/j.celrep.2024.114788 |
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2024 Journal Article Inflammasome components as new therapeutic targets in inflammatory diseaseColl, Rebecca C. and Schroder, Kate (2024). Inflammasome components as new therapeutic targets in inflammatory disease. Nature Reviews Immunology, 1-1. doi: 10.1038/s41577-024-01075-9 |
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2024 Journal Article The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axisHolley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012 |
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2024 Journal Article Mechanistic insights from inflammasome structuresFu, Jianing, Schroder, Kate and Wu, Hao (2024). Mechanistic insights from inflammasome structures. Nature Reviews Immunology, 24 (7), 1-18. doi: 10.1038/s41577-024-00995-w |
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2024 Journal Article Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophagesThygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515. doi: 10.1002/eji.202350515 |
