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Featured 2019 Journal Article Inflammasome signaling and regulation of interleukin-1 family cytokinesChan, Amy H. and Schroder, Kate (2019). Inflammasome signaling and regulation of interleukin-1 family cytokines. The Journal of Experimental Medicine, 217 (1) e20190314, jem.20190314. doi: 10.1084/jem.20190314 |
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Featured 2019 Journal Article Tiered DNA sensors for escalating responsesEmming, Stefan and Schroder, Kate (2019). Tiered DNA sensors for escalating responses. Science, 365 (6460), 1375-1376. doi: 10.1126/science.aay2701 |
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Featured 2019 Journal Article MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionColl, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7 |
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Featured 2018 Journal Article Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsChen, Kaiwen W., Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D., von Pein, Jessica B., Broz, Petr, Sweet, Matthew J. and Schroder, Kate (2018). Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Science Immunology, 3 (26) eaar6676, eaar6676. doi: 10.1126/sciimmunol.aar6676 |
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Featured 2018 Journal Article Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionMonteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027 |
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2018 Journal Article Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityBoucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222 |
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2015 Journal Article NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655 |
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Featured 2015 Journal Article A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesColl, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806 |
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Featured 2014 Journal Article The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella ChallengeChen, Kaiwen W., Groß, Christina J., Vasquez Sotomayor, Flor, Stacey, Katryn J., Tschopp, Jurg, Sweet, Matthew J. and Schroder, Kate (2014). The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge. Cell Reports, 8 (2), 570-582. doi: 10.1016/j.celrep.2014.06.028 |
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Featured 2012 Journal Article Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesSchroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109 |
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Featured 2010 Journal Article The inflammasomesSchroder, Kate and Tschopp, Jurg (2010). The inflammasomes. Cell, 140 (6), 821-832. doi: 10.1016/j.cell.2010.01.040 |
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Featured 2010 Journal Article NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?Tschopp, Jurg and Schroder, Kate (2010). NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?. Nature Reviews Immunology, 10 (3), 210-215. doi: 10.1038/nri2725 |
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Featured 2010 Journal Article The NLRP3 inflammasome: a sensor for metabolic danger?Schroder, Kate, Zhou, Rongbin and Tschopp, Jurg (2010). The NLRP3 inflammasome: a sensor for metabolic danger?. Science, 327 (5963), 269-300. doi: 10.1126/science.1184003 |
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2004 Journal Article Interferon-gamma: an overview of signals, mechanisms and functionsSchroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004). Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 (2), 163-189. doi: 10.1189/jlb.0603252 |
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2026 Journal Article Mitochondrial fission mediates an evolutionarily conserved antibacterial defense responseKapetanovic, Ronan, Afroz, Syeda Farhana, Curson, James E. B., Kirmes, Ina, Ramnath, Divya, Nothjunge, Stephan, Liu, Jinting, Atkinson, Jordan D., Ahier, Arnaud, Raven, Karoline D., Bosch, Marta, Keller, Bernhard, Lawrence, Grace M. E. P., Gupta, Kaustav Das, Shakespear, Melanie R., Ferguson, Charles, Stocks, Claudia J., Bokil, Nilesh J., Matthias, Gabriele, Nguyen, Tam T. K., Khalil, Zeinab G., Reid, Robert C., Hansford, Karl A., Hansbro, Philip M., Cooper, Matthew A., Schembri, Mark A., Blumenthal, Antje, Schroder, Kate, Fairlie, David P. ... Sweet, Matthew J. (2026). Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response. Science Immunology, 11 (118) eaed2623. doi: 10.1126/sciimmunol.aed2623 |
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2026 Journal Article ROS breaks the cofilin lock on NLRP3Mellacheruvu, Manasa and Schroder, Kate (2026). ROS breaks the cofilin lock on NLRP3. Nature Immunology. doi: 10.1038/s41590-026-02490-x |
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2026 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A., Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H. R., Cowin, Gary, Cui, Cedric S., Butler, Mark S., Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C., Schroder, Kate, Halai, Reena, MacLeod, Angus M., Matthews, Kim, Robertson, Avril A. B., Cooper, Matthew A. and Woodruff, Trent M. (2026). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain, 149 (4) awaf372, 1289-1301. doi: 10.1093/brain/awaf372 |
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2026 Journal Article NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killingWalker, Lachlan L., Nhu, Nguyen Thi Khanh, Lian, Zheng Jie, Peters, Kate M., Monteleone, Mercedes, Connolly, James P. R., Walker, Mark J., Forde, Brian M., Schroder, Kate, Sweet, Matthew J., Phan, Minh-Duy and Schembri, Mark A. (2026). NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killing. Journal of Bacteriology, 208 (3) e00610-25, 1-13. doi: 10.1128/jb.00610-25 |
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2025 Conference Publication State of Care of Patients With Autoinflammatory Disorders at the Queensland Children’s HospitalPinzon-Charry, Alberto, Tan, Joachim, Melo, Mariana, Wilcocks, Sophie, McNaughton, Peter, James, Rebecca, Peake, Jane, Schroder, Kate and Whitehead, Ben (2025). State of Care of Patients With Autoinflammatory Disorders at the Queensland Children’s Hospital. 35th Annual Conference of the Australasian Society of Clinical Immunology and Allergy (ASCIA), Brisbane, QLD Australia, 2-5 September 2025. New York, NY United States: Rockefeller University Press. doi: 10.70962/ascia2025abstract.p167 |
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2025 Journal Article NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stressYap, Jeremy Kean Yi, Duszyc, Kinga and Schroder, Kate (2025). NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress. Molecular Cell, 85 (20), 3853-3861. doi: 10.1016/j.molcel.2025.09.018 |
