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2026

Journal Article

NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killing

Walker, Lachlan L., Nhu, Nguyen Thi Khanh, Lian, Zheng Jie, Peters, Kate M., Monteleone, Mercedes, Connolly, James P. R., Walker, Mark J., Forde, Brian M., Schroder, Kate, Sweet, Matthew J., Phan, Minh-Duy and Schembri, Mark A. (2026). NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killing. Journal of Bacteriology, 208 (3) e00610-25, 1-13. doi: 10.1128/jb.00610-25

NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killing

2025

Conference Publication

State of Care of Patients With Autoinflammatory Disorders at the Queensland Children’s Hospital

Pinzon-Charry, Alberto, Tan, Joachim, Melo, Mariana, Wilcocks, Sophie, McNaughton, Peter, James, Rebecca, Peake, Jane, Schroder, Kate and Whitehead, Ben (2025). State of Care of Patients With Autoinflammatory Disorders at the Queensland Children’s Hospital. 35th Annual Conference of the Australasian Society of Clinical Immunology and Allergy (ASCIA), Brisbane, QLD Australia, 2-5 September 2025. New York, NY United States: Rockefeller University Press. doi: 10.70962/ascia2025abstract.p167

State of Care of Patients With Autoinflammatory Disorders at the Queensland Children’s Hospital

2025

Journal Article

NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress

Yap, Jeremy Kean Yi, Duszyc, Kinga and Schroder, Kate (2025). NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress. Molecular Cell, 85 (20), 3853-3861. doi: 10.1016/j.molcel.2025.09.018

NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress

2025

Journal Article

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

Pizzuto, Malvina, Monteleone, Mercedes, Burgener, Sabrina Sofia, Began, Jakub, Kurera, Melan, Chia, Jing Rong, Frampton, Emmanuelle, Crawford, Joanna, Oliveira, Monalisa, Kenney, Kirsten M., Coombs, Jared R., Yamamoto, Masahiro, Man, Si Ming, Broz, Petr, Pelegrin, Pablo and Schroder, Kate (2025). Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. The EMBO Journal, 44 (16), 4419-4442. doi: 10.1038/s44318-025-00507-z

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

2025

Other Outputs

Paraquat licences α-Synuclein to trigger NLRP3-dependent pyroptosis in microglia

Cao, Yuzhihan, Deora, Vandana, Khan, Nemat, Robertson, Avril A. B., Schroder, Kate, Cooper, Matthew A., Woodruff, Trent M. and Albornoz, Eduardo A. (2025). Paraquat licences α-Synuclein to trigger NLRP3-dependent pyroptosis in microglia. doi: 10.1101/2025.07.23.666340

Paraquat licences α-Synuclein to trigger NLRP3-dependent pyroptosis in microglia

2025

Journal Article

Spectosis: dying for a complement

Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2025). Spectosis: dying for a complement. Immunity, 58 (6), 1372-1374. doi: 10.1016/j.immuni.2025.05.017

Spectosis: dying for a complement

2025

Journal Article

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Burgener, Sabrina Sofia, Milner, Mark Thomas, Dey, Shoumit, Morgan, Pooranee K., Blackmore, Daniel G., Frampton, Emmanuelle, Miller, Gregory, Duarte de Oliveira, Monalisa, Kenney, Kirsten Myra, Bajracharya, Rinie, Baumgartner, Ulrich, Collins, Thomas J. C., Xiong, Zherui, Nguyen, Quan, Meikle, Peter J., Bodea, Liviu-Gabriel, Clouston, Andrew, Boucher, Dave, Götz, Jurgen, Murphy, Andrew J., Kaye, Paul M. and Schroder, Kate (2025). Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases. BioRxiv. doi: 10.1101/2025.04.28.651119

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

2025

Journal Article

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1 UK lineage

Richter, Johanna, Cork, Amanda J., Ong, Yvette, Keller, Nadia, Hayes, Andrew J., Schembri, Mark A., Jennison, Amy V., Davies, Mark R., Schroder, Kate, Walker, Mark J. and Brouwer, Stephan (2025). Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1 UK lineage. mBio, 16 (2) e0336624, e0336624. doi: 10.1128/mbio.03366-24

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1 UK lineage

2025

Journal Article

The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds

Chen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2025). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry, 23 (1), 174-182. doi: 10.1039/d4ob01453g

The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds

2025

Journal Article

Inflammasome components as new therapeutic targets in inflammatory disease

Coll, Rebecca C. and Schroder, Kate (2025). Inflammasome components as new therapeutic targets in inflammatory disease. Nature Reviews Immunology, 25 (1) 978513, 22-41. doi: 10.1038/s41577-024-01075-9

Inflammasome components as new therapeutic targets in inflammatory disease

2025

Journal Article

Towards a molecular and structural definition of cell death

Arama, Eli, Cosentino, Katia, Czabotar, Peter E., Gan, Boyi, Hartland, Elizabeth, Jiang, Xuejun, Kagan, Jonathan C., Nagata, Shigekazu, Schroder, Kate, Sun, Liming, Xu, Daichao and Yuan, Junying (2025). Towards a molecular and structural definition of cell death. Nature Structural and Molecular Biology, 32 (10), 1854-1858. doi: 10.1038/s41594-025-01646-x

Towards a molecular and structural definition of cell death

2024

Journal Article

Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease

Coll, Rebecca C. and Schroder, Kate (2024). Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease. Nature Reviews Immunology, 25 (2), 153-153. doi: 10.1038/s41577-024-01123-4

Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease

2024

Journal Article

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Holley, Caroline L., Monteleone, Mercedes, Fisch, Daniel, Libert, Alexandre E. S., Ju, Robert J., Choi, Joon H., Condon, Nicholas D., Emming, Stefan, Crawford, Joanna, Lawrence, Grace M. E. P., Coombs, Jared R., Lefevre, James G., Bajracharya, Rinie, Lahoud, Mireille H., Yap, Alpha S., Hamilton, Nicholas, Stehbens, Samantha J., Kagan, Jonathan C., Ariotti, Nicholas, Burgener, Sabrina S. and Schroder, Kate (2024). Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology, 26 (1) eaas8995, 1-35. doi: 10.1038/s41590-024-02024-3

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

2024

Journal Article

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

Pizzuto, Malvina, Monteleone, Mercedes, Burgener, Sabrina Sofia, Began, Jakub, Kurera, Melan, Chia, Jing Rong, Frampton, Emmanuelle, Crawford, Joanna, Oliveira, Monalisa, Kenney, Kirsten M., Coombs, Jared R., Yamamoto, Masahiro, Man, Si Ming, Broz, Petr, Pelegrin, Pablo and Schroder, Kate (2024). Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo. BioRxiv, 1-24. doi: 10.1101/2024.10.14.618051

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

2024

Journal Article

Ornithine lipid is a partial TLR4 agonist and NLRP3 activator

Pizzuto, Malvina, Hurtado-Navarro, Laura, Molina-Lopez, Cristina, Soubhye, Jalal, Gelbcke, Michel, Rodriguez-Lopez, Silvia, Ruysschaert, Jean-Marie, Schroder, Kate and Pelegrin, Pablo (2024). Ornithine lipid is a partial TLR4 agonist and NLRP3 activator. Cell Reports, 43 (10) 114788, 1-24. doi: 10.1016/j.celrep.2024.114788

Ornithine lipid is a partial TLR4 agonist and NLRP3 activator

2024

Journal Article

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

Holley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

2024

Journal Article

Mechanistic insights from inflammasome structures

Fu, Jianing, Schroder, Kate and Wu, Hao (2024). Mechanistic insights from inflammasome structures. Nature Reviews Immunology, 24 (7), 518-535. doi: 10.1038/s41577-024-00995-w

Mechanistic insights from inflammasome structures

2024

Journal Article

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

Thygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

2024

Journal Article

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

Coombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

2024

Journal Article

Publisher Correction:: Inflammasome components as new therapeutic targets in inflammatory disease (Nature Reviews Immunology, (2024), 10.1038/s41577-024-01075-9)

Coll, Rebecca C. and Schroder, Kate (2024). Publisher Correction:: Inflammasome components as new therapeutic targets in inflammatory disease (Nature Reviews Immunology, (2024), 10.1038/s41577-024-01075-9). Nature Reviews Immunology, 25 (2), 153-153. doi: 10.1038/s41577-024-01122-5

Publisher Correction:: Inflammasome components as new therapeutic targets in inflammatory disease (Nature Reviews Immunology, (2024), 10.1038/s41577-024-01075-9)