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2022 Journal Article NLRP3 and pyroptosis blockers for treating inflammatory diseasesColl, Rebecca C., Schroder, Kate and Pelegrín, Pablo (2022). NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends in Pharmacological Sciences, 43 (8), 653-668. doi: 10.1016/j.tips.2022.04.003 |
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2022 Journal Article Inflammatory caspases: toward a unified model for caspase activation by inflammasomesRoss, Connie, Chan, Amy H., von Pein, Jessica B., Maddugoda, Madhavi P., Boucher, Dave and Schroder, Kate (2022). Inflammatory caspases: toward a unified model for caspase activation by inflammasomes. Annual Review of Immunology, 40 (1), 249-269. doi: 10.1146/annurev-immunol-101220-030653 |
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2022 Journal Article Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossificationTseng, Hsu‐Wen, Kulina, Irina, Girard, Dorothée, Gueguen, Jules, Vaquette, Cedryck, Salga, Marjorie, Fleming, Whitney, Jose, Beulah, Millard, Susan M., Pettit, Allison R., Schroder, Kate, Thomas, Gethin, Wheeler, Lawrie, Genêt, François, Banzet, Sébastien, Alexander, Kylie A. and Levesque, Jean‐Pierre (2022). Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. Journal of Bone and Mineral Research, 37 (3), 531-546. doi: 10.1002/jbmr.4482 |
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2022 Journal Article Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell deathBonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316 |
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2022 Journal Article Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletionDonovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones-Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C and Hansbro, Philip M (2022). Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology, 100 (4), 235-249. doi: 10.1111/imcb.12537 |
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2021 Journal Article Caging NLRP3 tames inflammasome activitySchroder, Kate and Coll, Rebecca C. (2021). Caging NLRP3 tames inflammasome activity. Cell, 184 (26), 6224-6226. doi: 10.1016/j.cell.2021.11.035 |
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2021 Journal Article Endothelial cells are not productively infected by SARS‐CoV‐2Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350 |
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2021 Journal Article Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infectionRichter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499 |
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2021 Journal Article Inflammasome activation and IL ‐1β signalling in Group A Streptococcus diseaseRichter, Johanna, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease. Cellular Microbiology, 23 (9) e13373, 1-9. doi: 10.1111/cmi.13373 |
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2021 Journal Article SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophagesLucas, Richard M., Liu, Liping, Curson, James E. B., Koh, Yvette W. H., Tuladhar, Neeraj, Condon, Nicholas D., Das Gupta, Kaustav, Burgener, Sabrina S., Schroder, Kate, Ingley, Evan, Sweet, Matthew J., Stow, Jennifer L. and Luo, Lin (2021). SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Reports, 36 (10) 109662, 1-20. doi: 10.1016/j.celrep.2021.109662 |
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2021 Journal Article Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β releaseStarobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452 |
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2021 Journal Article The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s diseaseMilner, Mark T, Maddugoda, Madhavi, Götz, Jürgen, Burgener, Sabrina S and Schroder, Kate (2021). The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease. Current Opinion in Immunology, 68, 116-124. doi: 10.1016/j.coi.2020.10.011 |
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2021 Journal Article Placental inflammasome signaling: protection for mother and babyBurgener, Sabrina Sofia and Schroder, Kate (2021). Placental inflammasome signaling: protection for mother and baby. The Journal of Experimental Medicine, 218 (1) e20201738. doi: 10.1084/jem.20201738 |
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2021 Journal Article The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disordersChong, Wai Chin, Shastri, Madhur D., Peterson, Gregory M., Patel, Rahul P., Pathinayake, Prabuddha S., Dua, Kamal, Hansbro, Nicole G., Hsu, Alan C., Wark, Peter A., Shukla, Shakti Dhar, Johansen, Matt D., Schroder, Kate and Hansbro, Philip M. (2021). The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders. Clinical and Translational Immunology, 10 (2) e1247. doi: 10.1002/cti2.1247 |
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2020 Journal Article Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophagesKapetanovic, Ronan, Afroz, Syeda Farhana, Ramnath, Divya, Lawrence, Grace M.E.P., Okada, Takashi, Curson, James E.B., Bruin, Jost, Fairlie, David P., Schroder, Kate, St John, Justin C., Blumenthal, Antje and Sweet, Matthew J. (2020). Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98 (7) imcb.12363, 528-539. doi: 10.1111/imcb.12363 |
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2020 Journal Article Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probeHill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, 151849. doi: 10.1016/j.tetlet.2020.151849 |
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2020 Journal Article The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdownHolley, Caroline L. and Schroder, Kate (2020). The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown. Clinical & Translational Immunology, 9 (2) e01109, e01109. doi: 10.1002/cti2.1109 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2020 Journal Article Neutrophil-derived S100A8/A9 amplify granulopoiesis following myocardial infarctionSreejit, Gopalkrishna, Abdel-Latif, Ahmed, Athmanathan, Baskaran, Annabathula, Rahul, Dhyani, Ashish, Noothi, Sunil K, Quaife-Ryan, Gregory A., Al-Sharea, Annas, Pernes, Gerard, Dragoljevic, Dragana, Lal, Hind, Schroder, Kate, Hanaoka, Beatriz Y., Raman, Chander, Grant, Maria B., Hudson, James E., Smyth, Susan, Porrello, Enzo R., Murphy, Andrew J. and Nagareddy, Prabhakara R. (2020). Neutrophil-derived S100A8/A9 amplify granulopoiesis following myocardial infarction. Circulation, 141 (13), 1080-1094. doi: 10.1161/CIRCULATIONAHA.119.043833 |
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2020 Journal Article Neutrophil extracellular traps in host defenseBurgener, Sabrina Sofia and Schroder, Kate (2020). Neutrophil extracellular traps in host defense. Cold Spring Harbor Perspectives in Biology, 12 (7) a037028, a037028-15. doi: 10.1101/cshperspect.a037028 |
