|
2024 Journal Article Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalingXu, Calvin, Obers, Andreas, Qin, Minyi, Brandli, Alice, Wong, Joelyn, Huang, Xin, Clatch, Allison, Fayed, Aly, Starkey, Graham, D’Costa, Rohit, Gordon, Claire L., Mak, Jeffrey Y.W., Fairlie, David P., Beattie, Lynette, Mackay, Laura K., Godfrey, Dale I. and Koay, Hui-Fern (2024). Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. Journal of Experimental Medicine, 221 (12) e20240354, 1-22+. doi: 10.1084/jem.20240354 |
|
2024 Journal Article MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profilesKammann, Tobias, Cai, Curtis, Sekine, Takuya, Mouchtaridi, Elli, Boulouis, Caroline, Nilsén, Vera, Ballesteros, Olga Rivera, Müller, Thomas R., Gao, Yu, Raineri, Elisa J. M., Mily, Akhirunnesa, Adamo, Sarah, Constantz, Christian, Niessl, Julia, Weigel, Whitney, Kokkinou, Efthymia, Stamper, Christopher, Marchalot, Anne, Bassett, John, Ferreira, Sabrina, Rødahl, Inga, Wild, Nicole, Brownlie, Demi, Tibbitt, Chris, Mak, Jeffrey Y. W., Fairlie, David P., Leeansyah, Edwin, Michaelsson, Jakob, Marquardt, Nicole ... Sandberg, Johan K. (2024). MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles. Science Immunology, 9 (99) eadn2362, 1-15. doi: 10.1126/sciimmunol.adn2362 |
|
2024 Conference Publication Human MAIT cell profiles biased towards IL-17 or IL-10 are transient effector states directed by the cytokine milieuBoulouis, Caroline, Mouchtaridi, Elli, Muller, Thomas R., Mak, Jeffrey Y. W., Fairlie, David P., Bergman, Peter, Michaelsson, Jakob, Halfvarson, Jonas, Mjosberg, Jenny, Buggert, Marcus and Sandberg, Johan K. (2024). Human MAIT cell profiles biased towards IL-17 or IL-10 are transient effector states directed by the cytokine milieu. 7th European Conference of Immunology, Dublin, Ireland, 1-4 September 2024. Weinheim, Germany: Wiley. |
|
2024 Journal Article Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responsesPurohit, Shivam K., Stern, Lauren, Corbett, Alexandra J., Mak, Jeffrey Y.W., Fairlie, David P., Slobedman, Barry and Abendroth, Allison (2024). Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. PLoS Pathogens, 20 (8) e1012372, e1012372. doi: 10.1371/journal.ppat.1012372 |
|
2024 Journal Article Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesis. Angewandte Chemie, 136 (31) e202400632. doi: 10.1002/ange.202400632 |
|
2024 Journal Article MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitisZheng, Yichao, Han, Fei, Wu, Zhengyu, Wang, Bingjie, Chen, Xingchi, Boulouis, Caroline, Jiang, Yuebin, Ho, Amanda, He, Dan, Sia, Wan Rong, Mak, Jeffrey Y. W., Fairlie, David P., Wang, Lin-Fa, Sandberg, Johan K., Lobie, Peter E., Ma, Shaohua and Leeansyah, Edwin (2024). MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis. Science Advances, 10 (24) eadn6331, eadn6331. doi: 10.1126/sciadv.adn6331 |
|
2024 Journal Article MAIT cell-MR1 reactivity is highly conserved across multiple divergent speciesEdmans, Matthew D., Connelley, Timothy K., Morgan, Sophie, Pediongco, Troi J., Jayaraman, Siddharth, Juno, Jennifer A., Meehan, Bronwyn S., Dewar, Phoebe M., Maze, Emmanuel A., Roos, Eduard O., Paudyal, Basu, Mak, Jeffrey YW., Liu, Ligong, Fairlie, David P., Wang, Huimeng, Corbett, Alexandra J., McCluskey, James, Benedictus, Lindert, Tchilian, Elma, Klenerman, Paul and Eckle, Sidonia BG. (2024). MAIT cell-MR1 reactivity is highly conserved across multiple divergent species. Journal of Biological Chemistry, 300 (6) 107338, 1-21. doi: 10.1016/j.jbc.2024.107338 |
|
2024 Journal Article Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracilCiacchi, Lisa, Mak, Jeffrey Y.W., Le, Jeremy P., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie and Awad, Wael (2024). Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil. Journal of Biological Chemistry, 300 (5) 107229, 1-12. doi: 10.1016/j.jbc.2024.107229 |
|
2024 Journal Article Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomaliesKammann, Tobias, Gorin, Jean-Baptiste, Parrot, Tiphaine, Gao, Yu, Ponzetta, Andrea, Emgård, Johanna, Maleki, Kimia T., Sekine, Takuya, Rivera-Ballesteros, Olga, Gredmark-Russ, Sara, Rooyackers, Olav, Skagerberg, Magdalena, Eriksson, Lars I., Norrby-Teglund, Anna, Mak, Jeffrey Y. W., Fairlie, David P., Björkström, Niklas K., Klingström, Jonas, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus, Strålin, Kristoffer, Sandberg, Johan K. and Karolinska COVID-19 Study Group (2024). Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomalies. The Journal of Immunology, 212 (3), 389-396. doi: 10.4049/jimmunol.2300639 |
|
2024 Journal Article Sulfated bile acid is a host-derived ligand for MAIT cellsIto, Emi, Inuki, Shinsuke, Izumi, Yoshihiro, Takahashi, Masatomo, Dambayashi, Yuki, Ciacchi, Lisa, Awad, Wael, Takeyama, Ami, Shibata, Kensuke, Mori, Shotaro, Mak, Jeffrey Y. W., Fairlie, David P., Bamba, Takeshi, Ishikawa, Eri, Nagae, Masamichi, Rossjohn, Jamie and Yamasaki, Sho (2024). Sulfated bile acid is a host-derived ligand for MAIT cells. Science Immunology, 9 (91) eade6924, eade6924. doi: 10.1126/sciimmunol.ade6924 |
|
2023 Journal Article Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivoNelson, Adam G., Wang, Huimeng, Dewar, Phoebe M., Eddy, Eleanor M., Li, Songyi, Lim, Xin Yi, Patton, Timothy, Zhou, Yuchen, Pediongco, Troi J., Meehan, Lucy J., Meehan, Bronwyn S., Mak, Jeffrey Y. W., Fairlie, David P., Stent, Andrew W., Kjer-Nielsen, Lars, McCluskey, James, Eckle, Sidonia B. G., Corbett, Alexandra J., Souter, Michael N. T. and Chen, Zhenjun (2023). Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo. Frontiers in Immunology, 14 1109759, 1-15. doi: 10.3389/fimmu.2023.1109759 |
|
2023 Journal Article Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and diseaseWang, Yizhuo, Abrol, Rishika, Mak, Jeffrey Y. W., Das Gupta, Kaustav, Ramnath, Divya, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2023). Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease. The FEBS Journal, 290 (11), 2805-2832. doi: 10.1111/febs.16437 |
|
2022 Journal Article Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1Wang, Carl J.H., Awad, Wael, Liu, Ligong, Mak, Jeffrey Y.W., Veerapen, Natacha, Illing, Patricia T., Purcell, Anthony W., Eckle, Sidonia B.G., McCluskey, James, Besra, Gurdyal S., Fairlie, David P., Rossjohn, Jamie and Le Nours, Jérôme (2022). Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1. Journal of Biological Chemistry, 298 (12) 102714, 1-12. doi: 10.1016/j.jbc.2022.102714 |
|
2022 Journal Article A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cellsLim, Hui Jing, Wubben, Jacinta M., Garcia, Cristian Pinero, Cruz-Gomez, Sebastian, Deng, Jieru, Mak, Jeffrey Y.W., Hachani, Abderrahman, Anderson, Regan J., Painter, Gavin F., Goyette, Jesse, Amarasinghe, Shanika L., Ritchie, Matthew E., Roquilly, Antoine, Fairlie, David P., Gaus, Katharina, Rossjohn, Jamie, Villadangos, Jose A. and McWilliam, Hamish E.G. (2022). A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. Journal of Cell Biology, 221 (12) e202110125. doi: 10.1083/jcb.202110125 |
|
2022 Journal Article CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cellsSouter, Michael N.T., Awad, Wael, Li, Shihan, Pediongco, Troi J., Meehan, Bronwyn S., Meehan, Lucy J., Tian, Zehua, Zhao, Zhe, Wang, Huimeng, Nelson, Adam, Le Nours, Jérôme, Khandokar, Yogesh, Praveena, T., Wubben, Jacinta, Lin, Jie, Sullivan, Lucy C., Lovrecz, George O., Mak, Jeffrey Y.W., Liu, Ligong, Kostenko, Lyudmila, Kedzierska, Katherine, Corbett, Alexandra J., Fairlie, David P., Brooks, Andrew G., Gherardin, Nicholas A., Uldrich, Adam P., Chen, Zhenjun, Rossjohn, Jamie, Godfrey, Dale I. ... Eckle, Sidonia B.G. (2022). CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells. Journal of Experimental Medicine, 219 (9) e20210828, 1-30. doi: 10.1084/jem.20210828 |
|
2022 Journal Article Tuning electrostatic and hydrophobic surfaces of aromatic rings to enhance membrane association and cell uptake of peptidesde Araujo, Aline Dantes, Hoang, Huy N., Lim, Junxian, Mak, Jeffrey and Fairlie, David P. (2022). Tuning electrostatic and hydrophobic surfaces of aromatic rings to enhance membrane association and cell uptake of peptides. Angewandte Chemie International Edition, 61 (29) e202203995, e202203995. doi: 10.1002/anie.202203995 |
|
2022 Journal Article The balance of IL ‐12 and IL ‐23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infectionWang, Huimeng, Nelson, Adam G., Wang, Bingjie, Zhao, Zhe, Lim, Xin Yi, Shi, Mai, Meehan, Lucy J., Jia, Xiaoxiao, Kedzierska, Katherine, Meehan, Bronwyn S., Eckle, Sidonia B. G., Souter, Michael N. T., Pediongco, Troi J., Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Wang, Zhongfang, Corbett, Alexandra J. and Chen, Zhenjun (2022). The balance of IL ‐12 and IL ‐23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection. Immunology & Cell Biology, 100 (7), 547-561. doi: 10.1111/imcb.12556 |
|
2022 Journal Article Differential location of NKT and MAIT cells within lymphoid tissueJohnson, Darryl N., Ruan, Zheng, Petley, Emma V., Devi, Sapna, Holz, Lauren E., Uldrich, Adam P., Mak, Jeffrey Y. W., Hor, Jyh Liang, Mueller, Scott N., McCluskey, James, Fairlie, David P., Darcy, Phillip K., Beavis, Paul A., Heath, William R. and Godfrey, Dale I. (2022). Differential location of NKT and MAIT cells within lymphoid tissue. Scientific Reports, 12 (1) 4034, 4034. doi: 10.1038/s41598-022-07704-4 |
|
2022 Journal Article Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophagesTran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166 |
|
2021 Journal Article Human MAIT cells respond to and suppress HIV-1Phetsouphanh, Chansavath, Phalora, Prabhjeet, Hackstein, Carl-Philipp, Thornhill, John, Munier, Mee Ling, Meyerowitz, Jodi, Murray, Lyle, VanVuuren, Cloete, Goedhals, Dominique, Drexhage, Linnea, Moore, Rebecca, Sattentau, Quentin J, Mak, Jeffrey YW, Fairlie, David P, Fidler, Sarah, Kelleher, Anthony, Frater, John and Klenerman, Paul (2021). Human MAIT cells respond to and suppress HIV-1. eLife, 10 e50324. doi: 10.7554/elife.50324 |
