|
2024 Journal Article Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesis. Angewandte Chemie (International Edition), 63 (31) e202400632, e202400632. doi: 10.1002/anie.202400632 |
|
2021 Journal Article Chemical modulators of mucosal associated Invariant T cellsMak, Jeffrey Y.W., Liu, Ligong and Fairlie, David P. (2021). Chemical modulators of mucosal associated Invariant T cells. Accounts of Chemical Research, 54 (17) acs.accounts.1c00359, 3462-3475. doi: 10.1021/acs.accounts.1c00359 |
|
2021 Journal Article HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamatesMak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967 |
|
2020 Journal Article Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigensMcWilliam, Hamish E. G., Mak, Jeffrey Y. W., Awad, Wael, Zorkau, Matthew, Cruz-Gomez, Sebastian, Lim, Hui Jing, Yan, Yuting, Wormald, Sam, Dagley, Laura F., Eckle, Sidonia B. G., Corbett, Alexandra J., Liu, Haiyin, Li, Shihan, Reddiex, Scott J. J., Mintern, Justine D., Liu, Ligong, McCluskey, James, Rossjohn, Jamie, Fairlie, David P. and Villadangos, Jose A. (2020). Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens. Proceedings of the National Academy of Sciences, 117 (40), 1-12. doi: 10.1073/pnas.2011260117 |
|
2017 Journal Article Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cellsMak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong and Fairlie, David P. (2017). Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nature Communications, 8 (1) 14599, 14599. doi: 10.1038/ncomms14599 |
|
2014 Journal Article Natural Products with Anti-Bredt and Bridgehead Double BondsMak, Jeffrey Y. W., Pouwer, Rebecca H. and Williams, Craig M. (2014). Natural Products with Anti-Bredt and Bridgehead Double Bonds. Angewandte Chemie International Edition, 53 (50), 13664-13688. doi: 10.1002/anie.201400932 |
|
2014 Journal Article T-cell activation by transitory neo-antigens derived from distinct microbial pathwaysCorbett, Alexandra J., Eckle, Sidonia B. G., Birkinshaw, Richard W., Liu, Ligong, Patel, Onisha, Mahony, Jennifer, Chen, Zhenjun, Reantragoon, Rangsima, Meehan, Bronwyn, Cao, Hanwei, Williamson, Nicholas A., Strugnell, Richard A., Van Sinderen, Douwe, Mak, Jeffrey Y. W., Fairlie, David P., Kjer-Nielsen, Lars, Rossjohn, Jamie and McClusky, James (2014). T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 509 (7500), 361-365. doi: 10.1038/nature13160 |
|
2012 Journal Article Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin GMak, Jeffrey Y.W. and Williams, Craig M. (2012). Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G. Chemical Communications, 48 (2), 287-289. doi: 10.1039/c1cc15995j |
|
2025 Journal Article Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieuBoulouis, Caroline, Mouchtaridi, Elli, Müller, Thomas R., Mak, Jeffrey Y. W., Fairlie, David P., Bergman, Peter, Michaëlsson, Jakob, Halfvarson, Jonas, Mjösberg, Jenny, Buggert, Marcus and Sandberg, Johan K (2025). Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu. Proceedings of the National Academy of Sciences of the United States of America, 122 (6) e2414230122, 1-11. doi: 10.1073/pnas.2414230122 |
|
2025 Journal Article Cigarette smoke components modulate the MR1–MAIT axisAwad, Wael, Mayall, Jemma R., Xu, Weijun, Johansen, Matt D., Patton, Timothy, Lim, Xin Yi, Galvao, Izabela, Howson, Lauren J., Brown, Alexandra C., Haw, Tatt Jhong, Donovan, Chantal, Das, Shatarupa, Albers, Gesa J., Pai, Tsung-Yu, Hortle, Elinor, Gillis, Caitlin M., Hansbro, Nicole G., Horvat, Jay C., Liu, Ligong, Mak, Jeffrey Y.W., McCluskey, James, Fairlie, David P., Corbett, Alexandra J., Hansbro, Philip M. and Rossjohn, Jamie (2025). Cigarette smoke components modulate the MR1–MAIT axis. Journal of Experimental Medicine, 222 (2) e20240896, 1-19+. doi: 10.1084/jem.20240896 |
|
2024 Journal Article MAIT cell plasticity enables functional adaptation that drives antibacterial immune protectionWang, Huimeng, Souter, Michael N. T., de Lima Moreira, Marcela, Li, Shihan, Zhou, Yuchen, Nelson, Adam G., Yu, Jinhan, Meehan, Lucy J., Meehan, Bronwyn S., Eckle, Sidonia B. G., Lee, Hyun Jae, Schröder, Jan, Haque, Ashraful, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Wang, Zhongfang, Chen, Zhenjun and Corbett, Alexandra J. (2024). MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection. Science Immunology, 9 (102) eadp9841, eadp9841. doi: 10.1126/sciimmunol.adp9841 |
|
2024 Journal Article MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cellsMcInerney, Mitchell P., Awad, Wael, Souter, Michael N. T., Kang, Yang, Wang, Carl J. H., Chan Yew Poa, Kean, Abdelaal, Mohamed R., Le, Ngoc H., Shepherd, Chloe M., McNeice, Conor, Meehan, Lucy J., Nelson, Adam G., Raynes, Jeremy M., Mak, Jeffrey Y. W., McCluskey, James, Chen, Zhenjun, Ang, Ching-Seng, Fairlie, David P., Le Nours, Jérôme, Illing, Patricia T., Rossjohn, Jamie and Purcell, Anthony W. (2024). MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells. Proceedings of the National Academy of Sciences, 121 (49) e2414792121, e2414792121. doi: 10.1073/pnas.2414792121 |
|
2024 Journal Article Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalingXu, Calvin, Obers, Andreas, Qin, Minyi, Brandli, Alice, Wong, Joelyn, Huang, Xin, Clatch, Allison, Fayed, Aly, Starkey, Graham, D’Costa, Rohit, Gordon, Claire L., Mak, Jeffrey Y.W., Fairlie, David P., Beattie, Lynette, Mackay, Laura K., Godfrey, Dale I. and Koay, Hui-Fern (2024). Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. Journal of Experimental Medicine, 221 (12) e20240354. doi: 10.1084/jem.20240354 |
|
2024 Journal Article MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profilesKammann, Tobias, Cai, Curtis, Sekine, Takuya, Mouchtaridi, Elli, Boulouis, Caroline, Nilsén, Vera, Ballesteros, Olga Rivera, Müller, Thomas R., Gao, Yu, Raineri, Elisa J. M., Mily, Akhirunnesa, Adamo, Sarah, Constantz, Christian, Niessl, Julia, Weigel, Whitney, Kokkinou, Efthymia, Stamper, Christopher, Marchalot, Anne, Bassett, John, Ferreira, Sabrina, Rødahl, Inga, Wild, Nicole, Brownlie, Demi, Tibbitt, Chris, Mak, Jeffrey Y. W., Fairlie, David P., Leeansyah, Edwin, Michaelsson, Jakob, Marquardt, Nicole ... Sandberg, Johan K. (2024). MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles. Science Immunology, 9 (99) eadn2362, eadn2362. doi: 10.1126/sciimmunol.adn2362 |
|
2024 Journal Article Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responsesPurohit, Shivam K., Stern, Lauren, Corbett, Alexandra J., Mak, Jeffrey Y.W., Fairlie, David P., Slobedman, Barry and Abendroth, Allison (2024). Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. PLoS Pathogens, 20 (8 August) e1012372, e1012372. doi: 10.1371/journal.ppat.1012372 |
|
2024 Journal Article Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 BiosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis. Angewandte Chemie, 136 (31). doi: 10.1002/ange.202400632 |
|
2024 Journal Article MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitisZheng, Yichao, Han, Fei, Wu, Zhengyu, Wang, Bingjie, Chen, Xingchi, Boulouis, Caroline, Jiang, Yuebin, Ho, Amanda, He, Dan, Sia, Wan Rong, Mak, Jeffrey Y. W., Fairlie, David P., Wang, Lin-Fa, Sandberg, Johan K., Lobie, Peter E., Ma, Shaohua and Leeansyah, Edwin (2024). MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis. Science Advances, 10 (24) eadn6331, eadn6331. doi: 10.1126/sciadv.adn6331 |
|
2024 Journal Article MAIT cell-MR1 reactivity is highly conserved across multiple divergent speciesEdmans, Matthew D., Connelley, Timothy K., Morgan, Sophie, Pediongco, Troi J., Jayaraman, Siddharth, Juno, Jennifer A., Meehan, Bronwyn S., Dewar, Phoebe M., Maze, Emmanuel A., Roos, Eduard O., Paudyal, Basu, Mak, Jeffrey YW., Liu, Ligong, Fairlie, David P., Wang, Huimeng, Corbett, Alexandra J., McCluskey, James, Benedictus, Lindert, Tchilian, Elma, Klenerman, Paul and Eckle, Sidonia BG. (2024). MAIT cell-MR1 reactivity is highly conserved across multiple divergent species. Journal of Biological Chemistry, 300 (6) 107338, 1-21. doi: 10.1016/j.jbc.2024.107338 |
|
2024 Journal Article Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracilCiacchi, Lisa, Mak, Jeffrey Y.W., Le, Jeremy P., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie and Awad, Wael (2024). Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil. Journal of Biological Chemistry, 300 (5) 107229, 1-12. doi: 10.1016/j.jbc.2024.107229 |
|
2024 Journal Article Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomaliesKammann, Tobias, Gorin, Jean-Baptiste, Parrot, Tiphaine, Gao, Yu, Ponzetta, Andrea, Emgård, Johanna, Maleki, Kimia T., Sekine, Takuya, Rivera-Ballesteros, Olga, Gredmark-Russ, Sara, Rooyackers, Olav, Skagerberg, Magdalena, Eriksson, Lars I., Norrby-Teglund, Anna, Mak, Jeffrey Y. W., Fairlie, David P., Björkström, Niklas K., Klingström, Jonas, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus, Strålin, Kristoffer, Sandberg, Johan K. and Karolinska COVID-19 Study Group (2024). Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomalies. The Journal of Immunology, 212 (3), 389-396. doi: 10.4049/jimmunol.2300639 |
